Protein Kinase C- α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells
Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells Molecular Therapy 24, 1117 (June 2016). doi:10.1038/mt.2016.54 Authors: Daniela Castanotto, Min Lin, Claudia Kowolik, Troels Koch, Bo Rode Hansen, Henrik Oerum & Cy A Stein (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Daniela Castanotto Min Lin Claudia Kowolik Troels Koch Bo Rode Hansen Henrik Oerum Cy A Stein Source Type: research

Targeted Delivery of C/EBP α -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth In Vivo
Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth In Vivo Molecular Therapy 24, 1106 (June 2016). doi:10.1038/mt.2016.60 Authors: Sorah Yoon, Kai-Wen Huang, Vikash Reebye, Paul Mintz, Yu-Wen Tien, Hong-Shiee Lai, Pål Sætrom, Isabella Reccia, Piotr Swiderski, Brian Armstrong, Agnieszka Jozwiak, Duncan Spalding, Long Jiao, Nagy Habib & John J Rossi (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Sorah Yoon Kai-Wen Huang Vikash Reebye Paul Mintz Yu-Wen Tien Hong-Shiee Lai P ål Sætrom Isabella Reccia Piotr Swiderski Brian Armstrong Agnieszka Jozwiak Duncan Spalding Long Jiao Nagy Habib John J Rossi Source Type: research

rAAV Gene Therapy in a Canavan ’s Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System
rAAV Gene Therapy in a Canavan’s Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System Molecular Therapy 24, 1030 (June 2016). doi:10.1038/mt.2016.68 Authors: Seemin Seher Ahmed, Stefan A Schattgen, Ashley E Frakes, Elif M Sikoglu, Qin Su, Jia Li, Thomas G Hampton, Andrew R Denninger, Daniel A Kirschner, Brian Kaspar, Reuben Matalon & Guangping Gao (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Seemin Seher Ahmed Stefan A Schattgen Ashley E Frakes Elif M Sikoglu Qin Su Jia Li Thomas G Hampton Andrew R Denninger Daniel A Kirschner Brian Kaspar Reuben Matalon Guangping Gao Source Type: research

Corrigendum to “T-cell Subsets in Peripheral Blood and Tumors of Patients Treated With Oncolytic Adenoviruses”
Corrigendum to “T-cell Subsets in Peripheral Blood and Tumors of Patients Treated With Oncolytic Adenoviruses” Molecular Therapy 24, 1159 (June 2016). doi:10.1038/mt.2016.65 (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Source Type: research

Corrigendum to “Preclinical Safety and Efficacy of Human CD34+ Cells Transduced With Lentiviral Vector for the Treatment of Wiskott-Aldrich Syndrome”
Corrigendum to “Preclinical Safety and Efficacy of Human CD34+ Cells Transduced With Lentiviral Vector for the Treatment of Wiskott-Aldrich Syndrome” Molecular Therapy 24, 1159 (June 2016). doi:10.1038/mt.2016.96 (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Source Type: research

Randomized Phase 2 Trial of the Oncolytic Virus Pelareorep (Reolysin) in Upfront Treatment of Metastatic Pancreatic Adenocarcinoma
Zwiebel, Gregory B Lesinski, Miguel A Villalona-Calero & Tanios S Bekaii-Saab (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Anne M NoonanMatthew R FarrenSusan M GeyerYing HuangSanaa TahiriDaniel AhnSameh MikhailKristen K CiomborShubham PantSantiago AparoJennifer SextonJohn L MarshallThomas A MaceChristina S WuBassel El-RayesCynthia D TimmersJames ZwiebelGregory B LesinskiMigue Source Type: research

GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade
amp; Michael P Brown (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Tessa GargettWenbo YuGianpietro DottiEric S YvonSusan N ChristoJohn D HayballIan D LewisMalcolm K BrennerMichael P Brown Source Type: research

Allospecific Tregs Expanded After Anergization Remain Suppressive in Inflammatory Conditions but Lack Expression of Gut-homing Molecules
K Davies (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Eleni KotsiouJohn G GribbenJeff K Davies Source Type: research

Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells
Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells Molecular Therapy 24, 1117 (June 2016). doi:10.1038/mt.2016.54 Authors: Daniela Castanotto, Min Lin, Claudia Kowolik, Troels Koch, Bo Rode Hansen, Henrik Oerum & Cy A Stein (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Daniela CastanottoMin LinClaudia KowolikTroels KochBo Rode HansenHenrik OerumCy A Stein Source Type: research

Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth In Vivo
Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth In Vivo Molecular Therapy 24, 1106 (June 2016). doi:10.1038/mt.2016.60 Authors: Sorah Yoon, Kai-Wen Huang, Vikash Reebye, Paul Mintz, Yu-Wen Tien, Hong-Shiee Lai, Pål Sætrom, Isabella Reccia, Piotr Swiderski, Brian Armstrong, Agnieszka Jozwiak, Duncan Spalding, Long Jiao, Nagy Habib & John J Rossi (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Sorah YoonKai-Wen HuangVikash ReebyePaul MintzYu-Wen TienHong-Shiee LaiPål SætromIsabella RecciaPiotr SwiderskiBrian ArmstrongAgnieszka JozwiakDuncan SpaldingLong JiaoNagy HabibJohn J Rossi Source Type: research

Recombinant AAV Integration Is Not Associated With Hepatic Genotoxicity in Nonhuman Primates and Patients
nolaza & Manfred Schmidt (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Irene Gil-FarinaRaffaele FronzaChristine KaeppelEsperanza Lopez-FrancoValerie FerreiraDelia D’AvolaAlberto BenitoJesus PrietoHarald PetryGloria Gonzalez-AseguinolazaManfred Schmidt Source Type: research

Evaluating the Safety of Retroviral Vectors Based on Insertional Oncogene Activation and Blocked Differentiation in Cultured Thymocytes
Brian P Sorrentino (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Sheng ZhouSoghra FatimaZhijun MaYong-Dong WangTaihe LuLaura J JankeYang DuBrian P Sorrentino Source Type: research

Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System
Steven A Rosenberg (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Drew C DenigerAnna PasettoEric TranMaria R ParkhurstCyrille J CohenPaul F RobbinsLaurence JN CooperSteven A Rosenberg Source Type: research

Engineering Periodic shRNA for Enhanced Silencing Efficacy
Hammond (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Connie WuKevin E ShopsowitzPaula T Hammond Source Type: research

Genetic Manipulation of Brown Fat Via Oral Administration of an Engineered Recombinant Adeno-associated Viral Serotype Vector
amp; Lei Cao (Source: Molecular Therapy)
Source: Molecular Therapy - June 20, 2016 Category: Genetics & Stem Cells Authors: Wei HuangTravis McMurphyXianglan LiuChuansong WangLei Cao Source Type: research