Journal of Veterinary Pharmacology and Therapeutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Comparative plasma and interstitial fluid pharmacokinetics of flunixin meglumine and ceftiofur hydrochloride following individual and co ‐administration in dairy cows
The objective of this study was to determine whether pharmacokinetics of flunixin meglumine administered intravenously or intramuscularly administered ceftiofur hydrochloride would be altered when co‐administered versus individual administration to healthy dairy cattle. Ten cows were utilized in a three‐period, three‐treatment crossover design, with all cows receiving each treatment one time with a 10‐day washout period between treatments. Following treatment, plasma and interstitial fluid samples were collected and stored for later analysis. Additionally, plasma ultrafiltrate was collected using microcentrifugatio...
Source: Journal of Veterinary Pharmacology and Therapeutics - July 21, 2017 Category: Veterinary Research Authors: P. J. Gorden, M. D. Kleinhenz, L. W. Wulf, S. J. Rajewski, C. Wang, R. Gehring, J. F. Coetzee Tags: ORIGINAL ARTICLE Source Type: research

Plasma pharmacokinetics of quinocetone in ducks after oral and intravenous administration
This study enriches basic scientific data about pharmacokinetics of QCT in ducks after oral and intravenous administration and will be beneficial for clinical application in ducks. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - July 21, 2017 Category: Veterinary Research Authors: M. Qiu, Z. Hao, R. Zhang, L. Cui, C. Wang, S. Qu, S. Yuan, Y. Bai Tags: ORIGINAL ARTICLE Source Type: research

A comparative study between responses of isolated bovine and equine digital arteries to vasoactive mediators
This study compared the responsiveness of isolated bovine (BDA) and equine (EDA) digital arteries to pharmacological agents that stimulate receptor systems involved in the regulation of normal vessel tone. The role of the endothelium and the short‐ and longer‐term effects of an experimentally induced endothelial damage were also evaluated. Species‐related differences were found in the vessel reactivity to all of the receptor agonists tested. In intact BDA, as compared to intact EDA, norepinephrine was a more effective vasoconstrictor, 5‐hydroxytryptamine a more effective but less potent vasoconstrictor, isoproteren...
Source: Journal of Veterinary Pharmacology and Therapeutics - July 13, 2017 Category: Veterinary Research Authors: C. Zizzadoro, M. Caruso, S. Punzi, G. Crescenzo, F. Zongoli, C. Belloli Tags: ORIGINAL ARTICLE Source Type: research

Review of some pharmacokinetic and pharmacodynamic properties of anti ‐infective medicines administered to the koala (Phascolarctos cinereus)
Although koalas are iconic Australian animals, no pharmacokinetic studies of any first‐line medicines used to treat diseased or injured koalas had been published prior to 2010. Traditionally, medicine dosages suggested for this species underwent linear extrapolation from those recommended for domesticated species. The koala, a specialist folivore whose natural diet consists of almost exclusively Eucalyptus spp. foliage has anatomical and physiological adaptations for detoxifying their diet which also affect medicine pharmacokinetic profiles. This review addresses aspects of medicine absorption, clearance, and other indic...
Source: Journal of Veterinary Pharmacology and Therapeutics - July 13, 2017 Category: Veterinary Research Authors: M. Govendir Tags: REVIEW ARTICLE Source Type: research

Amelioration of oxidative stress using N ‐acetylcysteine in canine parvoviral enteritis
In this study, antioxidant potential of N‐acetylcysteine (NAC) in dogs infected with canine parvovirus with a nonblinded randomized clinical trial has been carried out. A total 18 parvo‐infected dogs were randomly divided into two groups: nine parvo‐infected dogs were treated with supportive treatment and nine parvo‐infected dogs were treated with NAC along with supportive treatment. Simultaneously, nine healthy dogs were kept as healthy control. In parvo‐infected dogs, marked hemoconcentration, leucopenia, neutropenia and oxidative stress were noticed compared to healthy dogs. The NAC treatment progressively imp...
Source: Journal of Veterinary Pharmacology and Therapeutics - July 12, 2017 Category: Veterinary Research Authors: C. Gaykwad, J. Garkhal, G. E. Chethan, S. Nandi, U. K. De Tags: ORIGINAL ARTICLE Source Type: research