Journal of Veterinary Pharmacology and Therapeutics 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Pharmacokinetics of tigecycline in turkeys following different routes of administration
The aim of this research had been to determine the pharmacokinetics of tigecycline (TIG) in turkey after intravenous (i.v.), intramuscular (i.m.), subcutaneous (s.c.), and oral (p.o.) administration at a dose of 10 mg/kg. TIG concentrations in plasma were determined using high‐performance liquid chromatography with tandem mass spectrometry. Mean concentrations of TIG in turkey plasma in the i.v. group were significantly higher than concentrations of this drug obtained after using the other administration routes. No significant differences were demonstrated in respect to the concentrations achieved after i.m. and s.c. ad...
Source: Journal of Veterinary Pharmacology and Therapeutics - August 19, 2017 Category: Veterinary Research Authors: A. Jasiecka ‐Mikołajczyk, H. Ziółkowski, J. J. Jaroszewski Tags: ORIGINAL ARTICLE Source Type: research
Review of triazine antiprotozoal drugs used in veterinary medicine
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 184-194, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - August 17, 2017 Category: Veterinary Research Source Type: research
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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 184-194, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - August 17, 2017 Category: Veterinary Research Source Type: research
Effect of dasatinib in a xenograft mouse model of canine histiocytic sarcoma and in vitro expression status of its potential target EPHA2
Canine histiocytic sarcoma (HS) is an aggressive and highly metastatic tumor. Previously, the kinase inhibitor dasatinib was shown to have potent growth inhibitory activity against HS cells in vitro, possibly via targeting the EPHA2 receptor. Here, the in vivo effect of dasatinib in HS cells was investigated using a xenograft mouse model. Moreover, the expression status of EPHA2 was examined in six HS cell lines, ranging from insensitive to highly sensitive to dasatinib. In the HS xenograft mouse model, dasatinib significantly suppressed tumor growth, as illustrated by a decrease in mitotic and Ki67 indices and an increase...
Source: Journal of Veterinary Pharmacology and Therapeutics - August 17, 2017 Category: Veterinary Research Authors: K. Ito, R. Miyamoto, H. Tani, S. Kurita, M. Kobayashi, K. Tamura, M. Bonkobara Tags: SHORT COMMUNICATION Source Type: research
Efficacy of a mephentermine ‐based product as a vasopressor and a cardiac performance enhancer when given intramuscularly to cattle
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 274-280, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - August 14, 2017 Category: Veterinary Research Source Type: research
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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 274-280, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - August 14, 2017 Category: Veterinary Research Source Type: research
Effects of polymyxin ‐B on TNF‐α production in equine whole blood stimulated with three different bacterial toxins
Polymyxin‐B is used to treat equine systemic inflammation. Bacterial toxins other than lipopolysaccharide (LPS) contribute to systemic inflammation but the effects of polymyxin‐B on these are poorly defined. Whole blood aliquots from six healthy horses diluted 1:1 with RPMI were incubated for 21 hr with 1 μg/ml of LPS, lipoteichoic acid (LTA) or peptidoglycan (PGN) in the presence of increasing concentrations of polymyxin‐B (10–3000 μg/ml). A murine L929 fibroblast bioassay was used to measure TNF‐α activity. Polymyxin‐B significantly inhibited the effects of all three bacterial toxins. Analysis of varian...
Source: Journal of Veterinary Pharmacology and Therapeutics - August 14, 2017 Category: Veterinary Research Authors: J. R. Bauquier, B. S. Tennent ‐Brown, E. Tudor, S. R. Bailey Tags: SHORT COMMUNICATION Source Type: research
Pharmacokinetics of cefquinome in red ‐eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections
The purpose of this study was to evaluate the pharmacokinetics of cefquinome (CFQ) following single intravenous (IV) or intramuscular (IM) injections of 2 mg/kg body weight in red‐eared slider turtles. Plasma concentrations of CFQ were determined by high‐performance liquid chromatography and analyzed using noncompartmental methods. The pharmacokinetic parameters following IV injection were as follows: elimination half‐life (t1/2λz) 21.73 ± 4.95 hr, volume of distribution at steady‐state (Vdss) 0.37 ± 0.11 L/kg, area under the plasma concentration–time curve (AUC0–∞) 163 ± 32 μg hr−1 ml−1,...
Source: Journal of Veterinary Pharmacology and Therapeutics - August 1, 2017 Category: Veterinary Research Authors: K. Uney, F. Altan, G. Cetin, M. Aboubakr, B. Dik, Z. Say ın, A. Er, M. Elmas Tags: SHORT COMMUNICATION Source Type: research
Review of triazine antiprotozoal drugs used in veterinary medicine
Triazines are relatively new antiprotozoal drugs that have successfully controlled coccidiosis and equine protozoal myeloencephalitis. These drugs have favorably treated other protozoal diseases such as neosporosis and toxoplasmosis. In this article, we discuss the pharmacological characteristics of five triazines, toltrazuril, ponazuril, clazuril, diclazuril, and nitromezuril which are used in veterinary medicine to control protozoal diseases which include coccidiosis, equine protozoal myeloencephalitis, neosporosis, and toxoplasmosis. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - August 1, 2017 Category: Veterinary Research Authors: M. L. Stock, S. T. Elazab, W. H. Hsu Tags: REVIEW ARTICLE Source Type: research
Comparison of the pharmacokinetic profiles of two different amphotericin B formulations in healthy dogs
This study was conducted to compare the pharmacokinetic profiles of conventional (Fungizone®) and liposomal amphotericin B (AmBisome®) formulations in order to predict their therapeutic properties, and evaluate their potential differences in veterinary treatment. For this purpose, twelve healthy mixed breed dogs received both drugs at a dose of 0.6 mg/kg by intravenous infusion over a 4‐min period in a total volume of 40 ml. Blood samples were collected at 0, 0.5, 1, 1.5, 2, 3, 4, 8, 12, 24, 48, 72 and 96 hr after dosing, and concentrations of drug in plasma were determined by high‐performance liquid chromatograph...
Source: Journal of Veterinary Pharmacology and Therapeutics - August 1, 2017 Category: Veterinary Research Authors: B. Bing öl, T. Bakirel Tags: ORIGINAL ARTICLE Source Type: research
Efficacy of a mephentermine ‐based product as a vasopressor and a cardiac performance enhancer when given intramuscularly to cattle
The goal of this study was to confirm the vasopressor and cardiac effects of POTENAY® INJETÁVEL (POT), a mephentermine‐based product, given to cattle with induced vascular/cardiac depression. Ten healthy Holstein cattle (206 ± 13 kg) followed a randomized‐complete‐block design (RCBD) utilizing crossover study design. Each animal randomly received (1 ml/25 kg, IM) of either POT (n = 10) or volume‐matched placebo control (0.9%NaCl, CP, n = 10). A subset of animals (n = 5) received POT first (day 0) while the remaining (n = 5) received CP; after a six‐day washout period, cattle received the opposite ...
Source: Journal of Veterinary Pharmacology and Therapeutics - August 1, 2017 Category: Veterinary Research Authors: D. N. Q. Cunha, C. L. Rio, B. L. Youngblood, E. L. Ferris, G. E. Geist, Y. Ueyama, L. C. Franz, S. Mathur, R. L. Hamlin Tags: ORIGINAL ARTICLE Source Type: research
Efficacy assessment of an intramammary treatment with a new recrystallized enrofloxacin vs ceftiofur and parenteral enrofloxacin in dairy cows with nonsevere clinical mastitis
A recrystallized form of enrofloxacin as dehydrate‐HCl (enro‐C) was assessed for bacteriological and clinical cure efficacies in Holstein‐Friesian cows affected of nonsevere clinical mastitis. Treatments were enro‐Csusp (n = 81), treated with a pharmaceutical suspension of enro‐C/quarter; group enro‐Cpd (n = 80) treated as above, but using enro‐C powder suspended in water; group CF (n = 65), treated with ceftiofur HCl/quarter; and group enroR (n = 66), treated with standard enrofloxacin solution (5 mg/kg, intramuscular). Cows had a mean milk production of 31 L/day and were 2‐3 lactational periods ...
Source: Journal of Veterinary Pharmacology and Therapeutics - July 28, 2017 Category: Veterinary Research Authors: M. Viveros, R. Lopez ‐Ordaz, L. Gutiérrez, J. E. Miranda‐Calderón, H. Sumano Tags: ORIGINAL ARTICLE Source Type: research
Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques
In this study, a real‐time PCR method was developed for genotyping these variants. The validity of the methods was verified by genotyping two wild type, two heterozygous, and two homozygous DNAs and was used to genotype 41 cynomolgus macaques (from Cambodia, Indonesia, the Philippines, or Vietnam) for the five variants, along with another important variant CYP2C19 (c.308C>T). The CYP2C9 and CYP2C19 variants were found only in Cambodian and Vietnamese animals, while the CYP2C76 and CYP2D6 variants were found only in Indonesian and Philippine animals. The CYP3A4 and CYP3A5 variants were not found in any of the animals a...
Source: Journal of Veterinary Pharmacology and Therapeutics - July 28, 2017 Category: Veterinary Research Authors: Y. Uno, N. Osada, S. Sakurai, N. Shimozawa, T. Iwata, K. Ikeo, H. Yamazaki Tags: SHORT COMMUNICATION Source Type: research
Pharmacokinetics of deflazacort in rabbits after intravenous and oral administration and its interaction with erythromycin
The pharmacokinetic of deflazacort after intravenous and oral administration and the effect of erythromycin on the disposition of deflazacort in rabbits were investigated. A parallel study was carried out in twelve rabbits. The plasma concentration–time profiles of deflazacort were determined after intravenous and oral administration of single dosages of 5 mg/kg in the presence and absence (baseline) of multiple dose erythromycin regimens. Plasma concentrations of 21‐desacetyldeflazacort were determined by HPLC. Plasma concentration–time curves were analysed by compartmental pharmacokinetic and noncompartmental meth...
Source: Journal of Veterinary Pharmacology and Therapeutics - July 25, 2017 Category: Veterinary Research Authors: A. I. Escudero, P. Mar ín, C. M. Cárceles, E. Escudero Tags: ORIGINAL ARTICLE Source Type: research
Pharmacokinetic –pharmacodynamic integration and modelling of oxytetracycline for the calf pathogens Mannheimia haemolytica and Pasteurella multocida
A calf tissue cage model was used to study the pharmacokinetics (PK) and pharmacodynamics (PD) of oxytetracycline in serum, inflamed (exudate) and noninflamed (transudate) tissue cage fluids. After intramuscular administration, the PK was characterized by a long mean residence time of 28.3 hr. Based on minimum inhibitory concentrations (MICs) for six isolates each of Mannheimia haemolytica and Pasteurella multocida, measured in serum, integration of in vivo PK and in vitro PD data established area under serum concentration–time curve (AUC0–∞)/MIC ratios of 30.0 and 24.3 hr for M. haemolytica and P. multocida, res...
Source: Journal of Veterinary Pharmacology and Therapeutics - July 24, 2017 Category: Veterinary Research Authors: P. Lees, T. Potter, L. Pelligand, P. ‐L. Toutain Tags: ORIGINAL ARTICLE Source Type: research
