Journal of Veterinary Pharmacology and Therapeutics 
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Journal of Veterinary Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 2, 2018 Category: Veterinary Research Source Type: research
Re ‐evaluation of the regulation of omeprazole in racehorses: An evidence‐based approach
In this study, pharmacokinetic data were produced in equine plasma and urine following an oral administration of 4 mg/kg of generic buffered formulation of omeprazole to six Thoroughbred horses in five daily doses to determine an appropriate screening limit and detection time in equine plasma and to assess whether the current detection time of 72 hr in equine urine would be applicable when an alternative omeprazole product is administered. Cmax of 436–2,432 ng/ml and AUC0–tau of 1,476–4,371 ng hr ml−1 were obtained for plasma and indicated, in conjunction with other published oral omeprazole studies, that an ...
Source: Journal of Veterinary Pharmacology and Therapeutics - February 1, 2018 Category: Veterinary Research Authors: M. Viljanto, L. Hillyer, P. Hincks, C. Pearce, S. W. Paine Tags: ORIGINAL ARTICLE Source Type: research
Pharmacokinetics of orbifloxacin in crucian carp (Carassius auratus) after intravenous and intramuscular administration
The pharmacokinetics of orbifloxacin was studied after a single dose (7.5 mg/kg) of intravenous or intramuscular administration to crucian carp (Carassius auratus) reared in freshwater at 25°C. Plasma samples were collected from six fish per sampling point. Orbifloxacin concentrations were determined by high‐performance liquid chromatography with a 0.02 μg/ml limit of detection, then were subjected to noncompartmental analysis. After intravenous injection, initial concentration of 5.83 μg/ml, apparent elimination rate constant (λz) of 0.039 hr−1, apparent elimination half‐life (T1/2λz) of 17.90 hr, systemic...
Source: Journal of Veterinary Pharmacology and Therapeutics - February 1, 2018 Category: Veterinary Research Authors: F. Yang, F. Yang, G. Wang, W. Shi, T. Kong, P. Yang, D. Bai, B. Zhou Tags: ORIGINAL ARTICLE Source Type: research
Pharmacokinetics of multiple doses of transdermal flunixin meglumine in adult Holstein dairy cows
A transdermal formulation of the nonsteroidal anti‐inflammatory drug, flunixin meglumine, has been approved in the United States and Canada for single‐dose administration. Transdermal flunixin meglumine was administered to 10 adult Holstein cows in their second or third lactation at the label dose of 3.33 mg/kg every 24 hr for three total treatments. Plasma flunixin concentrations were determined using high‐pressure liquid chromatography with mass spectroscopy (HPLC‐MS). Pharmacokinetic analysis was completed on each individual animal with noncompartmental methods using computer software. The time to maximum drug...
Source: Journal of Veterinary Pharmacology and Therapeutics - February 1, 2018 Category: Veterinary Research Authors: M. D. Kleinhenz, P. J. Gorden, J. S. Smith, J. A. Schleining, K. E. Kleinhenz, L. L. Wulf, P. K. Sidhu, D. Rea, J. F. Coetzee Tags: SHORT COMMUNICATION Source Type: research
Pharmacokinetics, pharmacodynamics, and metabolism of acepromazine following intravenous, oral, and sublingual administration to exercised Thoroughbred horses
This study describes serum and urine concentrations and the pharmacokinetics and pharmacodynamics of acepromazine following intravenous, oral, and sublingual (SL) administration. Fifteen exercised adult Thoroughbred horses received a single intravenous, oral, and SL dose of 0.09 mg/kg of acepromazine. Blood and urine samples were collected at time 0 and at various times for up to 72 hr and analyzed for acepromazine and its two major metabolites (2‐(1‐hydroxyethyl) promazine and 2‐(1‐hydroxyethyl) promazine sulfoxide) using liquid chromatography–tandem mass spectrometry. Acepromazine was also incubated in vitro ...
Source: Journal of Veterinary Pharmacology and Therapeutics - February 1, 2018 Category: Veterinary Research Authors: H. K. Knych, K. Seminoff, D. S. McKemie, P. H. Kass Tags: ORIGINAL ARTICLE Source Type: research
Comparison of milk and plasma pharmacokinetics of meloxicam in postpartum versus mid ‐lactation Holstein cows
The objective of this study reported here was determine whether differences occurred in meloxicam pharmacokinetics between postpartum cows and mid‐lactation cows. Preliminary data from a separate study (P. J. Gorden, unpublished data) in postpartum cows demonstrated elevated plasma and milk concentration profiles compared to previously published data (Malreddy, Coetzee, KuKanich, & Gehring, ). Two different groups were enrolled, each with 10 cows. The treatment group (TRT) was postpartum cows treated with meloxicam, and the positive control (PC) group was cows in mid‐lactation treated with meloxicam. Plasma and mil...
Source: Journal of Veterinary Pharmacology and Therapeutics - February 1, 2018 Category: Veterinary Research Authors: P. J. Gorden, M. Burchard, J. A. Ydstie, M. D. Kleinhenz, L. W. Wulf, S. J. Rajewski, C. Wang, R. Gehring, J. P. Mochel, J. F. Coetzee Tags: ORIGINAL ARTICLE Source Type: research
Effect of benazepril and pimobendan on serum angiotensin ‐converting enzyme activity in dogs
In conclusion, 0.25–0.5 mg/kg benazepril administered BID produced noninferior inhibition of serum ACE activity compared to 0.5–1.0 mg/kg benazepril dosed SID. Pimobendan had no significant effect on benazepril's action on serum ACE activity. The results support the use of benazepril BID in dogs and in combination with pimobendan. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 1, 2018 Category: Veterinary Research Authors: J. N. King, C. Christinaz, G. Strehlau, J. Hornfeld Tags: SHORT COMMUNICATION Source Type: research
Pharmacokinetics of cefquinome in healthy and Pasteurella multocida ‐infected rabbits
The pharmacokinetics of cefquinome were studied in healthy and Pasteurella multocida‐infected rabbits after a single intramuscular (IM) injection at 2 mg/kg of its sulfate salt. Twelve female New Zealand white rabbits (2.0–2.5 kg) were used; six of them served as controls, and the other six had been infected with P. multocida; the experiments were conducted 1–2 days after nasal inoculation of P. multocida when rabbits showed the signs of respiratory infection. Plasma concentrations of cefquinome were determined using high‐performance liquid chromatography. The values of elimination half‐life, area under the ...
Source: Journal of Veterinary Pharmacology and Therapeutics - January 31, 2018 Category: Veterinary Research Authors: S. T. Elazab, D. E. Schrunk, R. W. Griffith, S. M. Ensley, G. Dell'Anna, K. Mullin, M. G. Elsayed, M. S. Amer, S. M. El ‐Nabtity, W. H. Hsu Tags: PHARMACOKINETIC REPORT Source Type: research
Pharmacokinetics of cefquinome in healthy and Pasteurella multocida ‐infected rabbits
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 31, 2018 Category: Veterinary Research Source Type: research
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Journal of Veterinary Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 31, 2018 Category: Veterinary Research Source Type: research
Pharmacokinetics of single ‐dose sildenafil administered orally in clinically healthy dogs: Effect of feeding and dose proportionality
This study aimed to describe the pharmacokinetic properties of oral sildenafil and determine the effect of feeding and dose proportionality. The effect of feeding on pharmacokinetics of sildenafil (1 mg/kg) was investigated using a crossover study with six dogs. In addition, the dose proportionality of sildenafil ranging 1–4 mg/kg was evaluated using five dogs in the fasted states. The plasma concentrations of sildenafil were determined using high‐performance liquid chromatography, and pharmacokinetic parameters were calculated using a noncompartmental analysis. Sildenafil administrations were well tolerated in all s...
Source: Journal of Veterinary Pharmacology and Therapeutics - January 20, 2018 Category: Veterinary Research Authors: R. Akabane, T. Sato, A. Sakatani, Y. Miyagawa, H. Tazaki, N. Takemura Tags: ORIGINAL ARTICLE Source Type: research
Pharmacokinetics of single ‐dose sildenafil administered orally in clinically healthy dogs: Effect of feeding and dose proportionality
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 19, 2018 Category: Veterinary Research Source Type: research
The impact of MK ‐467 on plasma drug concentrations, sedation and cardiopulmonary changes in sheep treated with intramuscular medetomidine and atipamezole for reversal
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 19, 2018 Category: Veterinary Research Source Type: research
The bioequivalence of a single intravenous administration of the anesthetic alfaxalone in cyclodextrin versus alfaxalone in cyclodextrin plus preservatives in cats
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 19, 2018 Category: Veterinary Research Source Type: research
Pharmacokinetic profiles of the active metamizole metabolites after four different routes of administration in healthy dogs
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 19, 2018 Category: Veterinary Research Source Type: research
