Journal of Veterinary Pharmacology and Therapeutics 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Amoxicillin —current use in swine medicine
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 19, 2018 Category: Veterinary Research Source Type: research
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Journal of Veterinary Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 19, 2018 Category: Veterinary Research Source Type: research
Amoxicillin —current use in swine medicine
Amoxicillin has become a major antimicrobial substance in pig medicine for the treatment and control of severe, systemic infections such as Streptococcus suis. The minimum inhibitory concentration 90% (MIC 90) is 0.06 μg amoxicillin/ml, and the proposed epidemiological cut‐off value (ECOFF) is 0.5 μg/ml, giving only 0.7% of isolates above the ECOFF or of reduced susceptibility. Clinical breakpoints have not been set for amoxicillin against porcine pathogens yet, hence the use of ECOFFs. It has also been successfully used for bacterial respiratory infections caused by Actinobacillus pleuropneumoniae and Pasteurella mu...
Source: Journal of Veterinary Pharmacology and Therapeutics - January 19, 2018 Category: Veterinary Research Authors: D. G. S. Burch, D. Sperling Tags: REVIEW ARTICLE Source Type: research
Pharmacokinetic profiles of the active metamizole metabolites after four different routes of administration in healthy dogs
Metamizole (MT), an analgesic and antipyretic drug, is rapidly hydrolyzed to the active primary metabolite 4‐methylaminoantipyrine (MAA) and relatively active secondary metabolite 4‐aminoantipyrine (AA). The aim of this study was to assess the pharmacokinetic profiles of MAA and AA after dose of 25 mg/kg MT by intravenous (i.v.), intramuscular (i.m.), oral (p.o.), and rectal (RC) routes in dogs. Six dogs were randomly allocated to an open, single‐dose, four‐treatment, four‐phase, unpaired, crossover study design. Blood was collected at predetermined times within 24 hr, and plasma was analyzed by a validated HPL...
Source: Journal of Veterinary Pharmacology and Therapeutics - January 19, 2018 Category: Veterinary Research Authors: M. Giorgi, B. Łebkowska‐Wieruszewska, A. Lisowski, H. Owen, A. Poapolathep, T. W. Kim, V. De Vito Tags: ORIGINAL ARTICLE Source Type: research
The bioequivalence of a single intravenous administration of the anesthetic alfaxalone in cyclodextrin versus alfaxalone in cyclodextrin plus preservatives in cats
To demonstrate the bioequivalence of alfaxalone in cyclodextrin (Reference Product) to a formulation of alfaxalone in cyclodextrin also containing the preservatives ethanol, chlorocresol, and benzethonium chloride (Test Product) when administered for the purpose of inducing anesthesia in the cat. Blinded, single‐dose, randomized, two‐period, two‐sequence, cross‐over bioequivalence study with a 7‐day washout period between treatments. Twenty‐four (12 neutered males and 12 intact females), healthy, adult cats weighing 4.1±0.9 kg. Cats were administered 5 mg/kg IV of alfaxalone in the Reference or Test Product ...
Source: Journal of Veterinary Pharmacology and Therapeutics - January 19, 2018 Category: Veterinary Research Authors: K. Pasloske, M. G. Ranasinghe, S. Sauer, J. Hare Tags: ORIGINAL ARTICLE Source Type: research
The impact of MK ‐467 on plasma drug concentrations, sedation and cardiopulmonary changes in sheep treated with intramuscular medetomidine and atipamezole for reversal
In this study, MK‐467 appeared to have a pronounced effect on the plasma concentration and central effects of medetomidine, with minor cardiopulmonary improvement. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 19, 2018 Category: Veterinary Research Authors: M. Adam, M. R. Raekallio, T. Keskitalo, J. M. Honkavaara, M. Scheinin, M. Kajula, S. M ölsä, O. M. Vainio Tags: ORIGINAL ARTICLE Source Type: research
A single ‐nucleotide polymorphism in the canine cytochrome b5 reductase (CYB5R3) gene is associated with sulfonamide hypersensitivity and is overrepresented in Doberman Pinschers
Canine sulfonamide hypersensitivity (HS) has been associated with a variant in the cytochrome b5 reductase gene (CYB5R3 729A>G), which encodes a drug‐detoxifying enzyme. Study objectives were to determine variant allele frequency in Doberman Pinschers (DOBE), a breed which may be predisposed to sulfonamide HS, and to characterize the effects of CYB5R3 729G on gene expression and function. CYB5R3 729A>G allele frequencies were compared between DOBE (n = 24) vs. non‐Doberman (non‐DOBE; n = 60) dogs. CYB5R3mRNA expression, protein expression, and reduction of sulfamethoxazole hydroxylamine were compared betwee...
Source: Journal of Veterinary Pharmacology and Therapeutics - January 16, 2018 Category: Veterinary Research Authors: J. M. Reinhart, J. Ekena, A. C. Cioffi, L. A. Trepanier Tags: ORIGINAL ARTICLE Source Type: research
Fosfomycin residues in colostrum: Impact on morpho ‐physiology and microbiology of suckling piglets
In this study, the elimination of disodium fosfomycin in colostrum/milk of the sow and the impact of this antibiotic on the microbiota and intestinal morpho‐physiology of suckling piglets were analyzed. The average amount of fosfomycin eliminated in colostrum (after administration of 15 mg/kg IM) during the first 10 hr postpartum was 0.85 μg/ml, and the mean residual amount ingested by the piglets was 0.26 mg/kg. The elimination profile of fosfomycin concentrations in colostrum occurs at a time of profound changes in the morpho‐physiology of the gastrointestinal tract of the piglet. However, the studied concentrat...
Source: Journal of Veterinary Pharmacology and Therapeutics - January 15, 2018 Category: Veterinary Research Authors: M. B. Fern ández Paggi, G. Martínez, S. N. Diéguez, D. S. Pérez Gaudio, J. M. Decundo, M. B. Riccio, F. A. Amanto, M. O. Tapia, A. L. Soraci Tags: ORIGINAL ARTICLE Source Type: research
A single ‐nucleotide polymorphism in the canine cytochrome b5 reductase (CYB5R3) gene is associated with sulfonamide hypersensitivity and is overrepresented in Doberman Pinschers
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 15, 2018 Category: Veterinary Research Source Type: research
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Journal of Veterinary Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 15, 2018 Category: Veterinary Research Source Type: research
Fosfomycin residues in colostrum: Impact on morpho ‐physiology and microbiology of suckling piglets
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 14, 2018 Category: Veterinary Research Source Type: research
