Assessment of the pharmacological interactions between the nematodicidal fenbendazole and the flukicidal triclabendazole: In vitro studies with bovine liver microsomes and slices
Parasitic diseases have a significant impact on livestock production. Nematodicidal drugs, such as fenbendazole (FBZ) or its oxidized metabolite oxfendazole (OFZ), can be used along with the trematodicidal triclabendazole (TCBZ), to broaden the spectrum of anthelmintic activity. However, co‐exposure to these compounds could lead to drug–drug (D‐D) interactions and eventually alter the clinical profile of each active principle. The aim of this study was to assess the presence of such interactions by means of two in vitro models, namely bovine liver microsomal fractions and bovine precision‐cut liver slices (PCLSs). ...
Source: Journal of Veterinary Pharmacology and Therapeutics - February 21, 2018 Category: Veterinary Research Authors: P. Viviani, A. L. Lifschitz, M. L. Mat é, J. P. García, C. E. Lanusse, G. L. Virkel Tags: ORIGINAL ARTICLE Source Type: research

Pharmacokinetics of multiple doses of transdermal flunixin meglumine in adult Holstein dairy cows
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 20, 2018 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 20, 2018 Category: Veterinary Research Source Type: research

Development of a multiroute physiologically based pharmacokinetic model for orbifloxacin in rabbits
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 18, 2018 Category: Veterinary Research Source Type: research

Pharmacokinetics, pharmacodynamics, and metabolism of acepromazine following intravenous, oral, and sublingual administration to exercised Thoroughbred horses
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 18, 2018 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 18, 2018 Category: Veterinary Research Source Type: research

Development of a multiroute physiologically based pharmacokinetic model for orbifloxacin in rabbits
This study demonstrated the feasibility of predicting drug residues in minor species after multiple routes of administration in the extra‐label manner using the PBPK modeling. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 18, 2018 Category: Veterinary Research Authors: F. Yang, F. Yang, W. Shi, H. Si, T. Kong, G. Wang, J. Zhang Tags: ORIGINAL ARTICLE Source Type: research

Comparison of milk and plasma pharmacokinetics of meloxicam in postpartum versus mid ‐lactation Holstein cows
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 11, 2018 Category: Veterinary Research Source Type: research

Effects of p.o. administered xylitol in cats
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 11, 2018 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 11, 2018 Category: Veterinary Research Source Type: research

Effects of p.o. administered xylitol in cats
Xylitol is commonly used as sugar substitute in households. While it has numerous beneficial effects on human health, it is highly toxic to dogs. The goal of this study was to examine whether xylitol has similar deleterious effects, such as hypoglycaemia and acute hepatic failure, on cats. Our research included six healthy middle‐aged cats. Xylitol was dissolved in deionized water and administered p.o. at three doses (100, 500 and 1,000 mg/kg body weight). These dosages have been considered toxic and can cause liver failure or even death in dogs. After every xylitol administration, the basic health status and the blood ...
Source: Journal of Veterinary Pharmacology and Therapeutics - February 11, 2018 Category: Veterinary Research Authors: Á. Jerzsele, Z. Karancsi, E. Pászti‐Gere, Á. Sterczer, A. Bersényi, K. Fodor, D. Szabó, P. Vajdovich Tags: ORIGINAL ARTICLE Source Type: research

Effect of benazepril and pimobendan on serum angiotensin ‐converting enzyme activity in dogs
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 2, 2018 Category: Veterinary Research Source Type: research