Journal of Veterinary Pharmacology and Therapeutics 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Evaluation of the safety of daily administration of capromorelin in cats
The objective of this study was to evaluate the safety of daily oral administration of capromorelin to cats over a range of doses and for an extended period. Two randomized, controlled studies were conducted: in Study 1, cats (n = 6 per group) received placebo or capromorelin at a dose of 9, 15, 30 or 60 mg/kg once daily for 14 days; and in Study 2, cats received capromorelin at 6 mg/kg (n = 8) or placebo (n = 4) once daily for 91 days. Cats were evaluated using clinical observations and clinical pathology test results for both studies, with the addition of postmortem examination in Study 1 and measurements of gr...
Source: Journal of Veterinary Pharmacology and Therapeutics - October 22, 2017 Category: Veterinary Research Authors: J. A. Wofford, B. Zollers, L. Rhodes, M. Bell, E. Heinen Tags: ORIGINAL ARTICLE Source Type: research
Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t ‐TUCB in horses with experimentally induced radiocarpal synovitis
In conclusion, sEH inhibition with t‐TUCB may provide analgesia in horses with inflammatory joint pain. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - October 1, 2017 Category: Veterinary Research Authors: A. G. P. Guedes, F. Aristizabal, A. Sole, A. Adedeji, R. Brosnan, H. Knych, J. Yang, S. ‐H. Hwang, C. Morisseau, B. D. Hammock Tags: ORIGINAL ARTICLE Source Type: research
Ketoprofen pharmacokinetics of R ‐ and S‐isomers in juvenile loggerhead sea turtles (Caretta caretta) after single intravenous and single‐ and multidose intramuscular administration
Ketoprofen is a nonsteroidal anti‐inflammatory and analgesic agent that nonselectively inhibits cyclooxygenase, with both COX‐1 and COX‐2 inhibition. Recent studies on COX receptor expression in reptiles suggest that nonselective COX inhibitors may be more appropriate than more selective inhibitors in some reptiles, but few pharmacokinetic studies are available. The goal of this study was to determine single‐ and multidose (three consecutive days) pharmacokinetics of racemic ketoprofen administered intravenously and intramuscularly at 2 mg/kg in healthy juvenile loggerhead turtles (Caretta caretta). The S‐isomer...
Source: Journal of Veterinary Pharmacology and Therapeutics - October 1, 2017 Category: Veterinary Research Authors: K. A. Thompson, M. G. Papich, B. Higgins, J. Flanagan, E. F. Christiansen, C. A. Harms Tags: ORIGINAL ARTICLE Source Type: research
Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility —in vitro study
Continued ingestion of plant secondary metabolites by ruminants can provoke pharmacological interactions with pharmaceutical agents used in animals. As some drugs and phytocompounds affect smooth muscle activity, the aim of this study was to verify the possible interaction between selected pharmaceutical agents and plant secondary metabolites towards bovine gastrointestinal motility. The interactions between phytocompounds—apigenin, quercetin, hederagenin, medicagenic acid—and medicines—erythromycin, flunixin meglumine and levamisole—were evaluated on bovine isolated abomasal and duodenal specimens obtained from ro...
Source: Journal of Veterinary Pharmacology and Therapeutics - September 15, 2017 Category: Veterinary Research Authors: M. Mendel, M. Ch łopecka, N. Dziekan, W. Karlik Tags: ORIGINAL ARTICLE Source Type: research
Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility —in vitro study
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 281-291, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - September 14, 2017 Category: Veterinary Research Source Type: research
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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 281-291, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - September 14, 2017 Category: Veterinary Research Source Type: research
Pharmacogenetics of opioid analgesics in dogs
Genetic variation causes interindividual variability in drug absorption, distribution, metabolism and excretion. These pharmacokinetic processes will influence the observed efficacy and toxicity of a drug. Polymorphisms in the genes encoding the metabolizing enzymes, transport proteins and receptors have been linked to the inconsistency in responses to opioid treatment in humans and laboratory animals. Pharmacogenetics is relatively less developed field in veterinary medicine compared to significant advances in knowledge on genetic basis of variation in drug responses and clinical applications in human medicine. This revie...
Source: Journal of Veterinary Pharmacology and Therapeutics - September 11, 2017 Category: Veterinary Research Authors: K. Kongara Tags: REVIEW ARTICLE Source Type: research
Pharmacokinetics of a single intramuscular injection of cefquinome in buffalo calves
The objective of this study was to investigate the pharmacokinetics of cefquinome following single intramuscular (IM) administration in six healthy male buffalo calves. Cefquinome was administered intramuscularly (2 mg/kg bodyweight) and blood samples were collected prior to drug administration and up to 24 hr after injection. No adverse effects or changes were observed after the IM injection of cefquinome. Plasma concentrations of cefquinome were determined by high‐performance liquid chromatography. The disposition of plasma cefquinome is characterized by a mono‐compartmental open model. The pharmacokinetic paramete...
Source: Journal of Veterinary Pharmacology and Therapeutics - September 11, 2017 Category: Veterinary Research Authors: D. Venkatachalam, V. K. Dumka, B. Ranjan Tags: PHARMACOKINETIC REPORT Source Type: research
Pharmacokinetics of chlortetracycline in maternal plasma and in fetal tissues following oral administration to pregnant ewes
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 218-223, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - September 11, 2017 Category: Veterinary Research Source Type: research
Pharmacogenetics of opioid analgesics in dogs
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 195-204, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - September 11, 2017 Category: Veterinary Research Source Type: research
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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 218-223, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - September 11, 2017 Category: Veterinary Research Source Type: research
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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 195-204, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - September 11, 2017 Category: Veterinary Research Source Type: research
Pharmacokinetics of chlortetracycline in maternal plasma and in fetal tissues following oral administration to pregnant ewes
The purpose of this study was to determine if concentrations of chlortetracycline could be detected in fetal plasma or tissues after administering an oral dose of chlortetracycline (CTC; 500 mg/head/day) reported to be effective in controlling Campylobacter spp. abortions. Five pregnant ewes were administered 250 mg/head twice a day (total dose 500 mg/hd/d) for 7 days. On the beginning of day 7, intravenous catheters were surgically implanted or inserted into the fetus and dam. Plasma samples were collected from the ewe and fetus at various time points before and up to 36 hr after the last dose of CTC. All ewes were t...
Source: Journal of Veterinary Pharmacology and Therapeutics - September 11, 2017 Category: Veterinary Research Authors: K. Washburn, V. R. Fajt, P. Plummer, E. Papastavros, J. F. Coetzee, L. W. Wulf, S. Washburn Tags: PHARMACOKINETIC REPORT Source Type: research
Pharmacokinetics of tildipirosin in beagle dogs
The objective of this study was to investigate the pharmacokinetic profile of tildipirosin (TD) in 24 beagle dogs following intravenous (i.v.) and intramuscular (i.m.) administration, respectively, at 2, 4, and 6 mg/kg. Plasma samples at certain time points (0–14 days) were collected, and the concentrations of drug were quantified by UPLC‐MS/MS. Plasma concentration–time data and relevant parameters were described by noncompartmental through WinNonlin 6.4 software. After single i.m. injection at 2, 4, and 6 mg/kg body weight, mean maximum concentration (Cmax) was 412.73 ± 76.01, 1,051 ± 323, and 1,061 ± 3...
Source: Journal of Veterinary Pharmacology and Therapeutics - September 11, 2017 Category: Veterinary Research Authors: J. Wang, T. Zhao, X. Sun, Y. Liu, J. Zhu, S. Zhang, X. Cao Tags: SHORT COMMUNICATION Source Type: research
Effect of feeding on the pharmacokinetics of oral minocycline in healthy adult horses
This study's objective was to compare the pharmacokinetics of minocycline after administration of a single oral dose in horses with feed withheld and with feed provided at the time of drug administration. Six healthy adult horses were administered intravenous (2.2 mg/kg) and oral minocycline (4 mg/kg) with access to hay at the time of oral drug administration (fed) and with access to hay delayed for 2 hr after oral drug administration (fasted), with a 7‐day washout between treatments. Plasma concentration versus time data was analyzed based on noncompartmental pharmacokinetics. Mean ± SD bioavailability (fasted: 38...
Source: Journal of Veterinary Pharmacology and Therapeutics - September 11, 2017 Category: Veterinary Research Authors: K. O. Echeverria, K. M. Lascola, S. Gigu ère, J. H. Foreman Tags: SHORT COMMUNICATION Source Type: research
