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Pharmacokinetics, disposition, and plasma concentrations of dimethyl sulfoxide (DMSO) in the horse following topical, oral, and intravenous administration
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 14, 2018 Category: Veterinary Research Source Type: research

Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m ‐chlorophenylpiperazine in the horse
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 14, 2018 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 14, 2018 Category: Veterinary Research Source Type: research

Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m ‐chlorophenylpiperazine in the horse
Trazodone is a serotonin receptor antagonist and reuptake inhibitor used extensively as an anxiolytic in human and small animal veterinary medicine. The aims of this study were to determine the pharmacokinetics of oral trazodone in experimental horses and to evaluate the effect of oral trazodone in clinical horses. Six experimental horses were administered trazodone at 7.5 or 10 mg/kg. Plasma concentrations of trazodone and its metabolite (m‐CPP) were determined via UPLC‐MS/MS. Noncompartmental pharmacokinetic analysis, sedation and ataxia scores were determined. Trazodone was rapidly absorbed after oral administratio...
Source: Journal of Veterinary Pharmacology and Therapeutics - January 14, 2018 Category: Veterinary Research Authors: J. L. Davis, J. Schirmer, E. Medlin Tags: ORIGINAL ARTICLE Source Type: research

Pharmacokinetics, disposition, and plasma concentrations of dimethyl sulfoxide (DMSO) in the horse following topical, oral, and intravenous administration
Compartmental models were used to investigate the pharmacokinetics of intravenous (i.v.), oral (p.o.), and topical (TOP) administration of dimethyl sulfoxide (DMSO). The plasma concentration–time curve following a 15‐min i.v. infusion of DMSO was described by a two‐compartment model. Median and range of alpha (t1/2α) and beta (t1/2β) half‐lives were 0.029 (0.026–0.093) and 14.1 (6.6–16.4) hr, respectively. Plasma concentration–time curves of DMSO following p.o. and TOP administration were best described by one‐compartment absorption and elimination models. Following the p.o. administration, median absorpt...
Source: Journal of Veterinary Pharmacology and Therapeutics - January 14, 2018 Category: Veterinary Research Authors: L. R. Soma, M. A. Robinson, Y. You, R. C. Boston, J. Rudy Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 6, 2018 Category: Veterinary Research Tags: ISSUE INFORMATION Source Type: research

Network on veterinary medicines initiated by the European Federation For Pharmaceutical Sciences
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - December 20, 2017 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - December 20, 2017 Category: Veterinary Research Source Type: research

Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005 –2017)
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 205-217, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - December 11, 2017 Category: Veterinary Research Source Type: research

Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed ‐effects to characterize and quantify variability in drug pharmacokinetics
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 171-183, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - December 11, 2017 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 205-217, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - December 11, 2017 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 171-183, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - December 11, 2017 Category: Veterinary Research Source Type: research

Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005 –2017)
The objective of this review was to perform a literature compilation of all the equine publications that used dexmedetomidine as the first article on this topic was published, in 2005. We also aimed to answer the question whether the use of dexmedetomidine can currently be justified. For that, we compiled information from databases, such as PubMed, Google Scholar and Web of Science and the proceedings of the last veterinary anaesthesiology meetings. Dexmedetomidine is an attractive drug to be used in horses, mainly due to its pharmacokinetic profile and pharmacodynamics that favour its use as intravenous constant rate infu...
Source: Journal of Veterinary Pharmacology and Therapeutics - December 11, 2017 Category: Veterinary Research Authors: M. Gozalo ‐Marcilla, F. Gasthuys, S. P. L. Luna, S. Schauvliege Tags: REVIEW ARTICLE Source Type: research