Phenylbutazone induces equine glandular gastric disease without decreasing prostaglandin E2 concentrations
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 239-245, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 16, 2017 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 314-323, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 16, 2017 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 239-245, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 16, 2017 Category: Veterinary Research Source Type: research

Pharmacokinetic assessment of the monepantel plus oxfendazole combined administration in dairy cows
Monepantel (MNP) is a novel anthelmintic compound launched into the veterinary pharmaceutical market. MNP is not licenced for use in dairy animals due to the prolonged elimination of its metabolite monepantel sulphone (MNPSO2) into milk. The goal of this study was to evaluate the presence of potential in vivo drug‐drug interactions affecting the pattern of milk excretion after the coadministration of the anthelmintics MNP and oxfendazole (OFZ) to lactating dairy cows. The concentrations of both parent drugs and their metabolites were measured in plasma and milk samples by HPLC. MNPSO2 was the main metabolite recovered fr...
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Authors: M. Ballent, P. Viviani, F. Imperiale, P. Dominguez, S. Halwachs, H. Mahnke, W. Honscha, C. Lanusse, G. Virkel, A. Lifschitz Tags: ORIGINAL ARTICLE Source Type: research

Effects of the sodium ‐glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 266-273, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Source Type: research

Pharmacokinetic assessment of the monepantel plus oxfendazole combined administration in dairy cows
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 292-300, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Source Type: research

Tilmicosin ‐ and florfenicol‐loaded hydrogenated castor oil‐solid lipid nanoparticles to pigs: Combined antibacterial activities and pharmacokinetics
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 307-313, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Source Type: research

Safety of orally administered, USP ‐compliant levothyroxine sodium tablets in dogs
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 254-265, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 266-273, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 292-300, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 307-313, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Source Type: research

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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 254-265, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Source Type: research

Effects of the sodium ‐glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats
We examined the investigational SGLT2 inhibitor velagliflozin in two groups of six neutered adult obese cats (equal gender distribution). Placebo (Pl) or drug (D; 1 mg/kg) was administered for 35 days. Routine blood examinations, fructosamine, beta‐hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), glucagon, adiponectin, and leptin were measured before and after treatment, also water intake, and urinary electrolytes, glucose, and volume. Indirect calorimetry, an intravenous glucose tolerance test (IVGTT; 0.8 g/kg) and insulin tolerance test (IVITT) were conducted. All cats tolerated treatment well. Significant c...
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Authors: M. Hoenig, M. Clark, D. J. Schaeffer, D. Reiche Tags: ORIGINAL ARTICLE Source Type: research

Tilmicosin ‐ and florfenicol‐loaded hydrogenated castor oil‐solid lipid nanoparticles to pigs: Combined antibacterial activities and pharmacokinetics
This study suggests that the TIL‐FF‐SLN could be a useful oral formulation for the treatment of APP, S. suis, and HPS infection in pigs. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Authors: Z. Ling, L. Yonghong, L. Junfeng, Z. Li, L. Xianqiang Tags: ORIGINAL ARTICLE Source Type: research

Safety of orally administered, USP ‐compliant levothyroxine sodium tablets in dogs
The safety of synthetic levothyroxine sodium tablets (Thyro‐Tabs® Canine; LLOYD, Inc.) in dogs was evaluated in a randomized, sham‐dose controlled, parallel‐group study. Young, healthy, euthyroid Beagle dogs were randomized into four groups (four females and four males per group) and received single daily doses of 0×, 2× (0.044 mg/kg), 6× (0.132 mg/kg), or 10× (0.22 mg/kg) the labeled starting dose of 0.022 mg kg−1 day−1 for 182 days. Every 2 weeks, physical examinations, electrocardiology examinations, and sample collections for thyroid panel, hematology, serum biochemistry, coagulation panel, and u...
Source: Journal of Veterinary Pharmacology and Therapeutics - November 15, 2017 Category: Veterinary Research Authors: J. E. Hare, C. M. K. Morrow, J. Caldwell, W. E. Lloyd Tags: ORIGINAL ARTICLE Source Type: research