Journal of Veterinary Pharmacology and Therapeutics 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Network on veterinary medicines initiated by the European Federation For Pharmaceutical Sciences
The European Federation for Pharmaceutical Sciences (EUFEPS) was founded 25 years ago by more than 20 national pharmaceutical societies and faculty members. As a pan‐European organization, it brings together pharmaceutical societies as well as academic, industrial and regulatory scientists engaged in drug research and development, drug regulation and education of professionals working in these fields. EUFEPS represents pharmaceutical sciences in Europe and is recognized as such by both the European Commission and the European Medicines Agency. EUFEPS cooperates with the European Federation of Pharmaceutical Industries a...
Source: Journal of Veterinary Pharmacology and Therapeutics - December 1, 2017 Category: Veterinary Research Authors: J. P. Mochel, E. Tyden, K. Hellmann, J. C. Vendrig, S. Şenel, L. Dencker, R. T. Cristina, H. Linden, I. Schmerold Tags: ORIGINAL ARTICLE Source Type: research
Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed ‐effects to characterize and quantify variability in drug pharmacokinetics
A common feature of human and veterinary pharmacokinetics is the importance of identifying and quantifying the key determinants of between‐patient variability in drug disposition and effects. Some of these attributes are already well known to the field of human pharmacology such as bodyweight, age, or sex, while others are more specific to veterinary medicine, such as species, breed, and social behavior. Identification of these attributes has the potential to allow a better and more tailored use of therapeutic drugs both in companion and food‐producing animals. Nonlinear mixed effects (NLME) have been purposely designe...
Source: Journal of Veterinary Pharmacology and Therapeutics - December 1, 2017 Category: Veterinary Research Authors: C. Bon, P. L. Toutain, D. Concordet, R. Gehring, T. Martin ‐Jimenez, J. Smith, L. Pelligand, M. Martinez, T. Whittem, J. E. Riviere, J. P. Mochel Tags: REVIEW ARTICLE Source Type: research
Dietary exposure assessment of cyadox based on tissue depletion of cyadox and its major metabolites in pigs, chickens, and carp
The tissue kinetics of cyadox, an antibacterial agent used in food animals, and its major metabolites in pigs, chickens, and carp were investigated followed by a complete dietary exposure assessment to evaluate the food safety of cyadox. Cyadox and its major metabolites, bisdeoxycyadox (Cy1), 4‐desoxycyadox (Cy2), N‐(quinoxaline‐2‐methyl)‐cyanide acetyl hydrazine (Cy4), quinoxaline‐2‐carboxylic acid (Cy6), and 2‐hydromethyl‐3‐hydroxy‐quinoxaline (Cy12), were simultaneously quantitated with a high‐performance liquid chromatography−ultraviolet (HPLC‐UV) method. Pigs, chickens, and carp were fed wi...
Source: Journal of Veterinary Pharmacology and Therapeutics - December 1, 2017 Category: Veterinary Research Authors: L. L. Huang, Y. M. Qiu, L. L. Sun, J. Li, Y. H. Pan, Y. L. Wang, Z. H. Yuan Tags: ORIGINAL ARTICLE Source Type: research
Effects of selective α2‐adrenergic receptor agonists on electrical field‐stimulated contractions of isolated bronchi in horses
We investigated the effects of different selective α2‐adrenergic receptor (AR) agonists (detomidine, medetomidine, xylazine, and brimonidine) on the contractions of horse‐isolated bronchi induced by electrical field stimulation (EFS) and by carbachol. No effects were observed on the contraction induced by carbachol, while α2‐AR agonists reduced EFS‐evoked contractions in a concentration‐related fashion. The rank order of potency (pD2) was brimonidine (7.40 ± 0.20) >medetomidine (7.09 ± 0.24) >detomidine (6.13 ± 0.55) >xylazine (4.59 ± 0.16). The maximal effects (Emax) were −56.3% ± 6.3...
Source: Journal of Veterinary Pharmacology and Therapeutics - November 22, 2017 Category: Veterinary Research Authors: A. Menozzi, C. Pozzoli, E. Poli, C. Colla, G. Placenza, S. Bertini Tags: ORIGINAL ARTICLE Source Type: research
Pharmacokinetic profile of Ceftiofur Hydrochloride Injection in lactating Holstein dairy cows
In this study, the detailed pharmacokinetic profiles of free and total CEF showed that this drug is widely distributed and rapidly eliminated and may contribute to a better understanding of the usage of ceftiofur hydrochloride injection in Holstein dairy cows. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 21, 2017 Category: Veterinary Research Authors: J. Wang, H. Peng, J. Kong, T. Zhao, S. Zhang, X. Cao Tags: ORIGINAL ARTICLE Source Type: research
Pharmacokinetic profile of Ceftiofur Hydrochloride Injection in lactating Holstein dairy cows
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 301-306, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 21, 2017 Category: Veterinary Research Source Type: research
Pharmacokinetic profiles of the two major active metabolites of metamizole (dipyrone) in cats following three different routes of administration
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 334-339, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 21, 2017 Category: Veterinary Research Source Type: research
Effects of selective α2‐adrenergic receptor agonists on electrical field‐stimulated contractions of isolated bronchi in horses
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 246-253, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 21, 2017 Category: Veterinary Research Source Type: research
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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 301-306, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 21, 2017 Category: Veterinary Research Source Type: research
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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 334-339, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 21, 2017 Category: Veterinary Research Source Type: research
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Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 246-253, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 21, 2017 Category: Veterinary Research Source Type: research
Pharmacokinetic profiles of the two major active metabolites of metamizole (dipyrone) in cats following three different routes of administration
This study was performed to determine pharmacokinetic profiles of the two active metabolites of the analgesic drug metamizole (dipyrone, MET), 4‐methylaminoantipyrine (MAA), and 4‐aminoantipyrine (AA), after intravenous (i.v., intramuscular (i.m.), and oral (p.o.) administration in cats. Six healthy mixed‐breed cats were administered MET (25 mg/kg) by i.v., i.m., or p.o. routes in a crossover design. Adverse clinical signs, namely salivation and vomiting, were detected in all groups (i.v. 67%, i.m. 34%, and p.o. 15%). The mean maximal plasma concentration of MAA for i.v., i.m., and p.o. administrations was 148.63 ...
Source: Journal of Veterinary Pharmacology and Therapeutics - November 21, 2017 Category: Veterinary Research Authors: B. Lebkowska ‐Wieruszewska, T. W. Kim, B. Chea, H. Owen, A. Poapolathep, M. Giorgi Tags: ORIGINAL ARTICLE Source Type: research
Phenylbutazone induces equine glandular gastric disease without decreasing prostaglandin E2 concentrations
In equids, phenylbutazone at high doses induces gastric disease, primarily in the glandular portion of the stomach. However, the mechanism of nonsteroidal anti‐inflammatory drug (NSAID)‐induced gastric disease in horses has yet to be determined. While phenylbutazone‐associated ulceration is often attributed to a decrease in basal gastric prostaglandins, this has not been demonstrated in the horse. Twelve horses were randomly assigned to treatment (n = 6; 4.4 mg/kg phenylbutazone PO in 20 ml molasses q 12 hr for 7 days) or placebo (n = 6; 20 ml molasses PO q 12 hr for 7 days) groups. Before treatment and 3 ...
Source: Journal of Veterinary Pharmacology and Therapeutics - November 17, 2017 Category: Veterinary Research Authors: S. K. Pedersen, A. E. Cribb, E. K. Read, D. French, H. E. Banse Tags: ORIGINAL ARTICLE Source Type: research
PK/PD modeling of flunixin meglumine in a kaolin ‐induced inflammation model in piglets
Flunixin is marketed in several countries for analgesia in adult swine but little is known about its efficacy in piglets. Thirty‐two piglets (6–8 days old) were randomized to receive placebo saline (n = 11, group CONTROL) or flunixin meglumine intravenously at 2.2 (n = 11, group MEDIUM) or 4.4 (n = 10, group HIGH) mg/kg, 10 hr after subcutaneous injection of kaolin in the left metacarpal area. A hand‐held algometer was used to determine each piglet’s mechanical nociceptive threshold (MNT) from both front feet up to 50 hr after treatment (cut‐off value of 24.5 newton). Serial venous blood samples were obt...
Source: Journal of Veterinary Pharmacology and Therapeutics - November 16, 2017 Category: Veterinary Research Authors: O. L. Levionnois, T. K. Fosse, B. Ranheim Tags: ORIGINAL ARTICLE Source Type: research
PK/PD modeling of flunixin meglumine in a kaolin ‐induced inflammation model in piglets
Journal of Veterinary Pharmacology and Therapeutics,Volume 41, Issue 2, Page 314-323, April 2018. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - November 16, 2017 Category: Veterinary Research Source Type: research
