Journal of the American Society of Hypertension This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Latest Guidelines for Hypertension: Adopt and Adapt
The latest guidelines for hypertension evaluation and management published in this issue of JASH(1) represent a major contribution to the protection of public health. A distinguishing dimension of the just released new guidelines is the reclassification of hypertension (conveniently labeled as “categories of blood pressure”). A systolic blood pressure (SBP) level of 130-139 mm Hg, previously categorized as “pre-hypertension” in JNC 8 (2), is now assigned in the new guidelines as “Stage 1” hypertension. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - November 13, 2017 Category: Cardiology Authors: C. Venkata S. Ram Tags: Commentary Source Type: research

Association of office and ambulatory blood pressure with blood lead in workers before occupational exposure
In view of decreasing lead exposure and guidelines endorsing ambulatory above office blood pressure (BP) measurement, we reassessed association of BP with blood lead (BL) in 236 newly employed men (mean age, 28.6  years) without previous lead exposure not treated for hypertension. Office BP was the mean of five auscultatory readings at one visit. Twenty-four-hour BP was recorded at 15- and 30-minute intervals during wakefulness and sleep. BL was determined by inductively coupled plasma mass spectrometry. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - November 8, 2017 Category: Cardiology Authors: Wen-Yi Yang, Ljupcho Efremov, Blerim Mujaj, Zhen-Yu Zhang, Fang-Fei Wei, Qi-Fang Huang, Lutgarde Thijs, Thomas Vanassche, Tim S. Nawrot, Jan A. Staessen Tags: Research Article Source Type: research

Association of office and ambulatory blood pressure with blood lead in workers prior to occupational exposure
In view of decreasing lead exposure and guidelines endorsing ambulatory above office BP measurement, we re-assessed association of BP with blood lead (BL) in 236 newly employed men (mean age, 28.6 years) without previous lead exposure not treated for hypertension. Office BP was the mean of five auscultatory readings at one visit. 24-h BP was recorded at 15- and 30-minute intervals during wakefulness and sleep. BL was determined by inductively coupled plasma mass spectrometry. Systolic/diastolic office BP averaged 120.0/80.7 mm Hg and the 24-h, awake and asleep BP 125.5/73.6, 129.3/77.9 and 117.6/65.0 mm Hg, respectively. (...
Source: Journal of the American Society of Hypertension - November 8, 2017 Category: Cardiology Authors: Wen-Yi Yang, Ljupcho Efremov, Blerim Mujaj, Zhen-Yu Zhang, Fang-Fei Wei, Qi-Fang Huang, Lutgarde Thijs, Thomas Vanassche, Tim S. Nawrot, Jan A. Staessen Source Type: research

Interim report suggests that renal denervation appears to decrease ambulatory blood pressure in patients ‘off meds’ – a story that continues to unfold
Perhaps no potential cardiovascular intervention has enjoyed such a roller-coaster ride of expectation as catheter based renal denervation therapy (RDT) for the treatment of hypertension. Initial data from studies without a true sham control group demonstrated significant reductions in blood pressure (BP)1 and led to excess exuberance among many stakeholders. Then, when a single subsequent prospective randomized controlled trial of RDT versus sham procedure, Symplicity HTN-3,2 failed to demonstrate a significant reduction in ambulatory BP that exuberance turned to expressions of futility, which were likely just as irration...
Source: Journal of the American Society of Hypertension - November 1, 2017 Category: Cardiology Authors: Michael J. Bloch Tags: Hypertension Highlights Source Type: research

Editorial Board
(Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - November 1, 2017 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - November 1, 2017 Category: Cardiology Source Type: research

Instructions for Authors
(Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - November 1, 2017 Category: Cardiology Source Type: research

From the Editor
The demographics trends reveal that we are aging as a nation and that with each passing year a steadily increasing number of Americans exceed 65 years of age. While cardiovascular disease and cancer remain the most common causes of death in the U.S., older people are particularly concerned about their risks for cognitive impairment and dementia. Seshadri and colleagues1 estimated the cumulative risk of dementia at 33% for men and 45% for women from age 65 to age 100 years. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - November 1, 2017 Category: Cardiology Authors: Daniel Levy Tags: Editor's Page Source Type: research

Renal sympathetic denervation resurrected; or NOT?
Percutaneous renal denervation appeared in our medical life in recent years, created a lot of noise and then disappeared without any residual sign. The concept was that ablating the renal nerves would interrupt the signals from and to the kidneys (Figure  1) and thus eliminate the unnecessary production of renal hormones, the unnecessary sodium and fluid retention on one hand and the harmful effects of sympathetic overflow on target organs on the other. The early simplicity1,2 and other subsequent studies3,4 addressed patients with drug resistant h ypertension, a group of patients with unmet medical need. (Source: Journal...
Source: Journal of the American Society of Hypertension - November 1, 2017 Category: Cardiology Authors: Vasilios Papademetriou Tags: Hypertension Highlights Source Type: research

Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase
This study aims to investigate the effect of angiotensin-converting enzyme 2 (ACE2) activation on pulmonary endothelial function in the process of preventing pulmonary arterial hypertension (PAH) in rat models and to explore the underlying mechanisms. Specific pathogen free rats were randomly divided into five groups including control group, PAH group, PAH  + Resorcinolnaphthalein (Res) group (ACE2 activation), PAH + Res + MLN4760 group (ACE2 inhibition), and PAH + Res + L-NAME group (endothelial nitric oxide synthase [eNOS] inhibition). (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - October 27, 2017 Category: Cardiology Authors: Gang Li, Han Zhang, Lei Zhao, Yaozhong Zhang, Daole Yan, Yinglong Liu Tags: Research Article Source Type: research

Optimal blood pressure control after coronary events: the challenge remains
We identified sociodemographic, medical and psychosocial factors associated with unfavorable BP control in 1012 patients, hospitalized with myocardial infarction and/or a coronary revascularization procedure. This cross-sectional study collected data from hospital records, a comprehensive self-report questionnaire, clinical examination, and blood samples after 2-36 (mean 17) months follow-up. Forty-six percent had unfavorable BP control ( ≥140/90 [80 in diabetics] mmHg) at follow-up. Low socioeconomic status and psychosocial factors did not predict unfavorable BP control. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - October 27, 2017 Category: Cardiology Authors: Elise Sverre, Kari Peersen, Jan Erik Otterstad, Lars Gullestad, Joep Perk, Erik Gjertsen, Torbj ørn Moum, Einar Husebye, Toril Dammen, John Munkhaugen Tags: Research Article Source Type: research

Plasma microRNA-155-5p is increased among patients with chronic kidney disease and nocturnal hypertension
MicroRNA play multiple roles in the regulation of blood pressure. Nevertheless, to date no study has assessed the association between microRNA plasma expression and blood pressure (BP) control in chronic kidney disease (CKD) patients. Given this background, we evaluated the plasma expression of miR-155-5p, a translational inhibitor of angiotensin receptor type 1, in CKD patients, to determine the association between miR-155-5p level and BP control. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - October 27, 2017 Category: Cardiology Authors: Dominika Klimczak, Marek Kuch, Tomasz Pilecki, Dorota Zochowska, Agnieszka Wirkowska, Leszek Paczek Tags: Research Article Source Type: research

ACE2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of eNOS
This study aims to investigate the effect of ACE2 activation on pulmonary endothelial function in the process of preventing pulmonary arterial hypertension (PAH) in rat models and to explore the underlying mechanisms. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - October 27, 2017 Category: Cardiology Authors: Gang Li, Han Zhang, Lei Zhao, Yaozhong Zhang, Daole Yan, Yinglong Liu Tags: Research Article Source Type: research

Association of interleukin-6 with aortic stiffness in  end-stage renal disease
Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Aortic stiffness, a nontraditional risk factor, is associated with high rate of mortality in CKD. Using a CKD animal model with medial vascular calcification, we previously reported increased mRNA expression of interleukin-6 (IL-6), tumor necrosis factor (TNF), and interleukin-1 β (IL-1β) in calcified aorta. The aim of the study was to investigate the association between IL-6, TNF, IL-1β, and aortic stiffness in end-stage renal disease patients. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - October 13, 2017 Category: Cardiology Authors: Marie-Pier Desjardins, Aboubacar Sidib é, Catherine Fortier, Fabrice Mac-Way, Karine Marquis, Sacha De Serres, Richard Larivière, Mohsen Agharazii Tags: Research Article Source Type: research

Albuminuria and Kidney Function as Prognostic Marker of Left Ventricular Mass among South Asians with Hypertension
We aimed to evaluate the association of albuminuria and estimated glomerular filtration rate (eGFR) at baseline and changes in these parameters with left ventricular mass index (LVMI) at 7 years in adults with hypertension from communities in Pakistan. A nested cohort of 539 hypertensives aged 40 years and older from a community-living population in Karachi, Pakistan followed up for 7 years in the Control of Blood Pressure and Risk Attenuation (COBRA) trial. Urine spot albumin to creatinine ratio (UACR) and serum creatinine-based eGFR were assessed at baseline and 7 years, and echocardiography at 7 years. (Source: Journal ...
Source: Journal of the American Society of Hypertension - October 13, 2017 Category: Cardiology Authors: Liang Feng, Aamir Hameed Khan, Imtiaz Jehan, John Allen, Tazeen H. Jafar Tags: Research Article Source Type: research