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Clinical impact of dipping and nocturnal blood pressure patterns in newly diagnosed, never-treated patients with essential hypertension
The significance of nondipping and increased nighttime systolic blood pressure (SBP) in established hypertension is well defined. We investigated whether these factors alone or combined correlate with vascular damage in early-stage hypertension. Newly diagnosed, untreated hypertensives were classified as dippers and nondippers according to ambulatory blood pressure (BP). Twenty-four –hour urinary albumin excretion and markers of arterial stiffness (pulse wave velocity, augmentation index, central and peripheral pulse pressure, central BP) and atherosclerosis (carotid intima-media thickness) were assessed. (Source: Journa...
Source: Journal of the American Society of Hypertension - August 27, 2018 Category: Cardiology Authors: Eugenia Gkaliagkousi, Panagiota Anyfanti, Antonios Lazaridis, Areti Triantafyllou, Anastasios Vamvakis, Nikolaos Koletsos, Panagiotis Dolgyras, Stella Douma Tags: Research Article Source Type: research

Clinical impact of dipping and nocturnal blood pressure patterns in newly-diagnosed, never treated patients with essential hypertension
The significance of non-dipping and increased nighttime systolic blood pressure (SBP) in established hypertension is well-defined. We investigated whether these factors alone or combined correlate with vascular damage in early-stage hypertension. Newly diagnosed, untreated hypertensives were classified as dippers and non-dippers according to ambulatory blood pressure (BP). 24-h urinary albumin excretion (UAE) and markers of arterial stiffness (pulse wave velocity, augmentation index, central and peripheral pulse pressure, central BP) and atherosclerosis (carotid intima-media thickness) were assessed. (Source: Journal of th...
Source: Journal of the American Society of Hypertension - August 27, 2018 Category: Cardiology Authors: Eugenia Gkaliagkousi, Panagiota Anyfanti, Antonios Lazaridis, Areti Triantafyllou, Anastasios Vamvakis, Nikolaos Koletsos, Panagiotis Dolgyras, Stella Douma Tags: Research Article Source Type: research

Normal-range albuminuria in healthy subjects increases over time in association with hypertension and metabolic outcomes
Albuminuria is a prognostic factor for mortality and cardiovascular events, even at low levels. Changes in albumin excretion are associated with ESRD and hypertension in cohorts including high risk participants. We aimed to investigate the evolvement of albumin excretion in healthy individuals with normal kidney function and normo-albuminuria, and possible associations with hypertension and metabolic outcomes.The study cohort consisted of 1,967 healthy adults with normal kidney function [eGFR ≥90 ml/min/1.73m2; urine albumin to creatinine ratio (ACR) (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - August 22, 2018 Category: Cardiology Authors: Ayelet Grupper, Doron Schwartz, Shlomo Berliner, Moshe Shashar, Avishay Grupper, Roni Baruch, Idit F. Schwartz, Talia Weinstein, Orit Kliuk Ben-Bassat, Ori Rogowski, David Zeltser, Itzhak Shapira, Shani Shenhar-Tsarfaty Tags: Research Article Source Type: research

Cardiovascular safety of mirabegron: analysis of an integrated clinical trial database of patients with overactive bladder syndrome
Mirabegron is a β3-adrenoreceptor agonist used for the treatment of overactive bladder syndrome. We evaluated the cardiovascular safety of mirabegron using pooled data from 13 studies. The analysis included 13,396 patients who received ≥1 dose of mirabegron (25 mg/50 mg) or comparator antimuscarinics (solifenaci n 2.5 mg/5 mg/10 mg or tolterodine extended release 4 mg) as monotherapies, or placebo. We focused on changes in blood pressure and cardiovascular adverse events. Baseline cardiovascular risk factors had an imbalanced effect on subsequent cardiovascular adverse events. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - August 10, 2018 Category: Cardiology Authors: William B. White, Emad Siddiqui, Tri Tat, Billy Franks, Carol R. Schermer Tags: Research Article Source Type: research

Regarding “Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians”
I read the study by Oliver-Williams et  al.1 with interest. The authors conducted a prospective study to assess the association between baseline urinary cadmium and longitudinal changes in blood pressure of American Indian. A one-unit increase in log-transformed urinary cadmium to creatinine ratio was significantly associated with 10% g reater hypertension risk with 95% confidence interval of 1.01–1.20. I have some concerns with this study. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - August 8, 2018 Category: Cardiology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research

Regarding "Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians"
I read the study by Oliver-Williams et al. with interest.1 The authors conducted a prospective study to assess the association between baseline urinary cadmium and longitudinal changes in blood pressure of American Indian. A one-unit increase in log-transformed urinary cadmium to creatinine ratio was significantly associated with 10% greater hypertension risk with 95% confidence interval of 1.01-1.20. I have some concerns with this study. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - August 8, 2018 Category: Cardiology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research

Association between Subjective Sleep Duration on Workdays or Non-workdays and Uncontrolled Blood Pressure in Southern China
To examine the association between sleep duration on workdays or non-workdays and unsatisfactory blood pressure (BP) control in southern China. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - August 3, 2018 Category: Cardiology Authors: Lihua Hu, Yihua Zhou, Xiao Huang, Qian Liang, Chunjiao You, Wei Zhou, Juxiang Li, Ping Li, Yanqing Wu, Qinghua Wu, Zengwu Wang, Runlin Gao, Huihui Bao, Xiaoshu Cheng Tags: Research Article Source Type: research

A concise predictive nomogram for renal artery stenosis in selective patients undergoing coronary angiography
As reported scoring systems of renal artery stenosis (RAS) screening were not easily validated, we further proposed a simple method to predict or rule out RAS in selective patients undergoing coronary angiography (CAG). After preliminary inclusive criterion (severe hypertension or atherosclerosis, flash pulmonary edema, or unexplained renal dysfunction), 503 and 158 consecutive patients undergoing renal arteriography at the timing of CAG were separately enrolled between 2012 and 2015, and 2016 and 2017 as the development and validation cohort. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - July 25, 2018 Category: Cardiology Authors: Haojian Dong, Zhiqiang Nie, Wenhui Huang, Yuan Liu, Guang Li, Yanqiu Ou, Yingling Zhou, Jianfang Luo Tags: Research Article Source Type: research

A concise prediction nomogram for renal artery stenosis in selective patients undergoing coronary angiography
As reported scoring systems of renal artery stenosis (RAS) screening were not easily validated, we further proposed a simple method to predict or rule out RAS in selective patients undergoing coronary angiography (CAG). After preliminary inclusive criterion (severe hypertension or atherosclerosis, flash pulmonary edema, or unexplained renal dysfunction), 503 and 158 consecutive patients undergoing renal arteriography at the timing of CAG were separately enrolled between 2012 and 2015, and 2016 and 2017 as the development and validation cohort. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - July 25, 2018 Category: Cardiology Authors: Haojian Dong, Zhiqiang Nie, Wenhui Huang, Yuan Liu, Guang Li, Yanqiu Ou, Yingling Zhou, Jianfang Luo Source Type: research

Commentary: Postmicturition syndrome: a neglected syndrome dangerous for the bladder and the heart
Romano et  al describe a rare case of catecholamine-secreting bladder paraganglioma (PGL) presenting with postmicturition syndrome. PGLs are rare neuroendocrine tumors of autonomic paraganglia derived from the embryonic neural crest. Sympathetic PGLs are located in the sympathetic paravertebral ganglia of th orax, abdomen, and pelvis (such as bladder PGL) and commonly secrete catecholamines. Inversely, parasympathetic PGLs are located along the glossopharyngeal and vagal nerves in the neck and at the skull base and are typically nonfunctioning. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - July 23, 2018 Category: Cardiology Authors: Oksana Hamidi, Todd B. Nippoldt Tags: Commentary Source Type: research

Commentary: Post-micturition syndrome: a neglected syndrome dangerous for the bladder and the heart
Romano et al describe a rare case of catecholamine-secreting bladder paraganglioma (PGL) presenting with post-micturition syndrome. PGLs are rare neuroendocrine tumors of autonomic paraganglia derived from the embryonic neural crest. Sympathetic PGLs are located in the sympathetic paravertebral ganglia of thorax, abdomen, and pelvis (such as bladder PGL) and commonly secrete catecholamines. Inversely, parasympathetic PGLs are located along the glossopharyngeal and vagal nerves in the neck and at the skull base and are typically nonfunctioning. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - July 23, 2018 Category: Cardiology Authors: Oksana Hamidi, Todd B. Nippoldt Tags: Commentary Source Type: research

Arginine impairs endothelial and executive function in older subjects with cardiovascular risk
Neurovascular coupling, the relationship between cerebral blood flow and neuronal activity, is attenuated in patients with impaired executive function. We tested the hypothesis that peripheral vascular function may associate with executive function in older subjects with cardiovascular risk factors and that treatment with the antioxidant L-arginine would improve both vascular and executive function. Nineteen subjects with type 2 diabetes mellitus and/or controlled hypertension were enrolled. Subjects were treated with L-arginine or placebo for 4  days in a randomized, double-blinded, cross-over study. (Source: Journal of ...
Source: Journal of the American Society of Hypertension - July 10, 2018 Category: Cardiology Authors: Joshua A. Beckman, Shelley Hurwitz, Naomi D.L. Fisher Tags: Research Article Source Type: research

Physical activity and sedentary behavior thresholds for identifying childhood hypertension and its phenotypes: The Healthy Growth Study
Hypertension phenotypes may represent differential pathophysiologic mechanisms and clinical impact, yet they have been poorly investigated. The study aimed to examine the associations of physical activity and sedentary behavior with hypertension phenotypes in a large group of Greek children and to identify thresholds regarding risk of hypertension. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - July 10, 2018 Category: Cardiology Authors: Kalliopi Karatzi, George Moschonis, Sofia Botelli, Odysseas Androutsos, George P. Chrousos, Christos Lionis, Yannis Manios Tags: Research Article Source Type: research

Arginine Impairs Endothelial And Executive Function In Older Subjects With Cardiovasculr Risk
Neurovascular coupling, the relationship between cerebral blood flow and neuronal activity, is attenuated in patients with impaired executive function. We tested the hypothesis that peripheral vascular function may associate with executive function in older subjects with cardiovascular risk factors, and that treatment with the antioxidant L-arginine would improve both vascular and executive function. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - July 10, 2018 Category: Cardiology Authors: Joshua A. BECKMAN, Shelley HURWITZ, Naomi D.L. FISHER Tags: Research Article Source Type: research

Editor's page
It is with great pleasure that the Journal of the American Society of Hypertension publishes in this issue the Executive Summary of the recent American College of Cardiology/American Heart Association blood pressure guidelines [1]. The American Society of Hypertension was one of the member organizations that participated in the extensive process that led to the new blood pressure guidelines and several of the authors of the evidence=based document are long-term leaders of the Society. The new guidelines reflect new knowledge, including recent clinical trials results that have impacted the practice recommendations. (Source:...
Source: Journal of the American Society of Hypertension - July 4, 2018 Category: Cardiology Authors: Daniel Levy Source Type: research