Mechanisms of pulse pressure amplification dipping pattern during sleep time: the SAFAR study
The difference in pulse pressure (PP) between peripheral arteries and the aorta, called pulse pressure amplification (PPamp), is a well-described physiological phenomenon independently associated with cardiovascular events. Recent studies suggest that it exhibits circadian variability. Our aim was to detect the factors associated with the circadian variability of PPamp. In 497 consecutive subjects (aged 54 years, 56.7% male, 79.7% hypertensives) we assessed the circadian pattern of peripheral and central arterial hemodynamics by 24-hour evaluation of brachial and aortic blood pressure (BP), augmentation index (AI) and puls...
Source: Journal of the American Society of Hypertension - December 13, 2017 Category: Cardiology Authors: Antonios A. Argyris, Efthimia Nasothimiou, Evaggelia Aissopou, Theodoros G. Papaioannou, Yi Zhang, Jacques Blacher, Michel E. Safar, Petros P. Sfikakis, Athanase D. Protogerou Tags: Research Article Source Type: research

Control of cardiovascular disease risk factors among patients with type 2 diabetes in a primary care setting in Beijing
The aim of this study was to assess the control of blood glucose, blood pressure, serum low density lipoprotein cholesterol (LDL-c), and other cardiovascular disease (CVD) risk factors among patients with type 2 diabetes in a primary care setting in Beijing. We performed a cross-sectional, multi-center survey of 4056 patients with type 2 diabetes ≥40 years old. In total, 22.6% were current smokers, 10.8% often drank alcohol, 29.0 were obesity, and 67.4% participated in adequate levels of physical activity. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - December 13, 2017 Category: Cardiology Authors: Hui-Juan Zuo, Wen-Hua Wang, Li-Qun Deng, Jiang-Lian Su Tags: Research Article Source Type: research

Aldosterone as a mediator of microvascular and macrovascular damage in a population of normotensive to early-stage hypertensive individuals
We investigated whether aldosterone concurrently mediates microvascular and macrovascular impairment, in a population of treatment-na ïve young- to middle-aged individuals free from cardiovascular comorbidities. Newly diagnosed, never-treated essential hypertensive patients and normotensive individuals participated in the study. Pulse wave velocity (PWV) and augmentation index were estimated with applanation tonometry. Microalbum inuria was determined from 24-hour urine collections. Laboratory tests included measurement of plasma renin activity, serum aldosterone, and high-sensitivity C-reactive protein. (Source: Journal ...
Source: Journal of the American Society of Hypertension - December 11, 2017 Category: Cardiology Authors: Eugenia Gkaliagkousi, Panagiota Anyfanti, Areti Triantafyllou, Eleni Gavriilaki, Barbara Nikolaidou, Antonios Lazaridis, Anastasios Vamvakis, Stella Douma Tags: Research Article Source Type: research

Aldosterone as a mediator of micro- and macrovascular damage in a population of normotensive to early-stage hypertensive individuals
We investigated whether aldosterone concurrently mediates micro- and macrovascular impairment, in a population of treatment-na ïve young to middle-aged individuals free from cardiovascular comorbidities. Newly-diagnosed, never-treated essential hypertensive patients and normotensive individuals participated in the study. Pulse wave velocity (PWV) and augmentation index (AIx) were estimated with applanation tonometry. Micro albuminuria was determined from 24-hour urine collections. Laboratory tests included measurement of plasma renin activity, serum aldosterone, and high-sensitivity C-reactive protein (hsCRP). (Source: Jo...
Source: Journal of the American Society of Hypertension - December 11, 2017 Category: Cardiology Authors: Eugenia Gkaliagkousi, Panagiota Anyfanti, Areti Triantafyllou, Eleni Gavriilaki, Barbara Nikolaidou, Antonios Lazaridis, Anastasios Vamvakis, Stella Douma Tags: Research Article Source Type: research

Recent data from National Health and Nutrition Examination Survey (NHANES) demonstrates no improvement in U.S. blood pressure control rates
As part of their Heathy People 2020 project the U.S. government Office of Disease Prevention and Health Promotion (ODPHP) set a goal that at least 61.2% of Americans with hypertension be controlled by the year 2020.1 In 2010 when this goal was announced it seemed quite attainable. The previous decade had seen a steady  increase in national blood pressure control rates. In 1999-2000 the National Health and Nutrition Examination Survey (NHANES) determined that the U.S. blood pressure control rate was 31.6%, and by 2009-2010 the rate of blood pressure control had increased to 53.1%. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - December 6, 2017 Category: Cardiology Authors: Michael J. Bloch Tags: Hypertension Highlights Source Type: research

The effect of intermittent fasting on blood pressure variability in patients with newly diagnosed hypertension or prehypertension
Intermittent fasting is a phenomenon which can be observed in most humans. The effect of intermittent fasting on blood pressure variability (BPV) has not previously been investigated. The purpose of this study was to assess the effect of fasting on BP (with office, home, central and ambulatory blood pressure monitoring [ABPM]) and on BPV. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - December 5, 2017 Category: Cardiology Authors: Yunus Erdem, G ülsüm Özkan, Şükrü Ulusoy, Mustafa Arıcı, Ülver Derici, Şule Şengül, Şükrü Sindel, Şehsuvar Ertürk, Turkish Society of Hypertension and Renal Diseases Tags: Research Article Source Type: research

Angiotensin II Type 2 Receptor Inhibits Expression and Function of Insulin Receptor in Rat Renal Proximal Tubule Cells
Both renin –angiotensin systems and insulin participate in kidney-involved blood pressure regulation. Activation of angiotensin II type 2 receptor (AT2R) decreases sodium reabsorption in renal proximal tubule (RPT) cells, whereas insulin produces the opposite effect. We presume that AT2R has an inhibitory ef fect on insulin receptor expression in RPT cells, which may affect renal sodium transport and therefore be of physiological or pathological significance. Our present study found that activation of AT2R inhibited insulin receptor expression in a concentration and time-dependent manner in RPT cells fr om Wistar-Kyoto (...
Source: Journal of the American Society of Hypertension - December 5, 2017 Category: Cardiology Authors: Yang Yang, Caiyu Chen, Chunjiang Fu, Zaicheng Xu, Cong Lan, Yongchun Zeng, Zhi Chen, Pedro A. Jose, Ye Zhang, Chunyu Zeng Tags: Research Article Source Type: research

In a Dramatic Shift, Most Recent Data Suggest that the Majority of CV Events Occur in Adults with Blood Pressure < 140/90 mmHg
Observational studies have demonstrated a graded association between both systolic and diastolic blood pressure (BP) and cardiovascular risk. Additionally, a number of observational studies, including the Framingham studies and the Atherosclerosis Risk in Communities study1 from prior to the year 2000 suggested that the majority of cardiovascular events, occurred in adults with observed systolic BP>140 mmHg or diastolic BP>90 mmHg. However, high BP is not the only risk factor for cardiovascular events, and the relative population attributable risk of various cardiovascular risk factors may vary with time and across populat...
Source: Journal of the American Society of Hypertension - December 1, 2017 Category: Cardiology Authors: Michael J. Bloch Tags: Hypertension Highlight Source Type: research

Editorial Board
(Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - December 1, 2017 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - December 1, 2017 Category: Cardiology Source Type: research

From the Editor
I recently attended the 2017 Scientific Sessions of the American Heart Association in Anaheim. One of the most highly featured events of the meeting was the release of the new 2017 American College of Cardiology/American Heart Association guidelines on high blood pressure.1 The new blood pressure guidelines are the culmination of a huge effort by a multidisciplinary task force of 21 experts, including representatives from the American Society of Hypertension. The new guideline process began with the formulation of several critical questions regarding the classification and treatment of elevated blood pressure. (Source: Jou...
Source: Journal of the American Society of Hypertension - December 1, 2017 Category: Cardiology Authors: Daniel Levy Tags: Editor's Page Source Type: research

Thanks to Our Reviewers
Critical Scientific Peer-Review is the Life-Blood of Scientific Communication. We Offer Our Sincerest Thanks to Those Named Below Who Gave Generously of Their Time and Expertise to Provide the Requisite Advice. Without the Dedication of Our Reviewers, JASH Would Not Have Been Possible. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - December 1, 2017 Category: Cardiology Source Type: research

High dietary intake of aromatic amino acids increases risk of hypertension
Recent studies investigated the relation between amino acids and blood pressure. Our aim was to examine the association between intake of aromatic amino acids (AAAs) and risk of hypertension. A total of 4288 individuals, aged 20-70 years, participants of the Tehran Lipid and Glucose Study (TLGS), who were free of hypertension at baseline (2008-2011) were followed for 3 years (2011-2014). Average intakes of AAAs including phenylalanine, tyrosine, and tryptophan were collected using a valid and reliable food frequency questionnaire at baseline. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - November 23, 2017 Category: Cardiology Authors: Farshad Teymoori, Golaleh Asghari, Parvin Mirmiran, Fereidoun Azizi Source Type: research

Relation of urinary endothelin-1 to stress-induced pressure natriuresis in healthy adolescents
We hypothesize that delayed natriuresis during mental stress increases the risk of hypertension and other diseases. Our pre-clinical studies demonstrate an important role for renal endothelin-1 (ET-1) in regulating sodium excretion. Thus, we predict ET-1 may be linked to the delayed stress response in at-risk individuals. We hypothesize that reduced renal ET-1 accounts for derangements in sodium handling under stress, a link never explored in a large human cohort. We determined urinary ET-1 excretion in three observational studies of changes in sodium excretion during mental stress, in which 776 healthy youth (15 –19 ye...
Source: Journal of the American Society of Hypertension - November 23, 2017 Category: Cardiology Authors: Shreya Mathur, Jennifer S. Pollock, Sunil Mathur, Gregory A. Harshfield, David M. Pollock Tags: Research Article Source Type: research

Occupational noise exposure and hypertension: the Dongfeng-Tongji Cohort Study
The association between occupational noise exposure and hypertension is unclear. We aimed to explore the association in a Chinese population and to summarize our findings with previous published articles. The cross-sectional study included 22450 participants from Dongfeng-tongji Cohort Study. In a subsample of 10636 subjects, we assessed the association between hearing loss and hypertension. For the meta-analysis, we searched Pubmed and Embase until April 2017, and the pooled odds ratio was combined by using a random-effect model. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - November 13, 2017 Category: Cardiology Authors: Dongming Wang, Min Zhou, Wenzhen Li, Weijia Kong, Zhichao Wang, Yanjun Guo, Xiaomin Zhang, Meian He, Huan Guo, Weihong Chen Source Type: research