Aldosterone as a mediator of microvascular and macrovascular damage in a population of normotensive to early-stage hypertensive individuals

We investigated whether aldosterone concurrently mediates microvascular and macrovascular impairment, in a population of treatment-na ïve young- to middle-aged individuals free from cardiovascular comorbidities. Newly diagnosed, never-treated essential hypertensive patients and normotensive individuals participated in the study. Pulse wave velocity (PWV) and augmentation index were estimated with applanation tonometry. Microalbum inuria was determined from 24-hour urine collections. Laboratory tests included measurement of plasma renin activity, serum aldosterone, and high-sensitivity C-reactive protein.

Source: Journal of the American Society of Hypertension - December 11, 2017 Category: Cardiology Authors: Eugenia Gkaliagkousi, Panagiota Anyfanti, Areti Triantafyllou, Eleni Gavriilaki, Barbara Nikolaidou, Antonios Lazaridis, Anastasios Vamvakis, Stella Douma Tags: Research Article Source Type: research