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Vascular toxicities with VEGF inhibitor therapies –focus on hypertension and arterial thrombotic events
The vascular endothelial growth factor (VEGF) signaling pathway (VSP) fulfills a cardinal role in endothelial cells and its inhibition has profound cardiovascular impact. This is true not only for the normal vasculature but also for the tumor vasculature when VSP inhibitors are used as anti-angiogenic therapies. Generalized endothelial dysfunction predisposes to vasoconstriction, atherosclerosis, platelet activation, and thrombosis (arterial more than venous). All of these have been reported with VSP inhibitors and collectively give rise to vascular toxicities, the most concerning of which are arterial thromboembolic event...
Source: Journal of the American Society of Hypertension - March 22, 2018 Category: Cardiology Authors: Rhian M. Touyz, Sandra M.S. Herrmann, Joerg Herrmann Tags: Review Article Source Type: research

Rationale and evidence for the development of a durable device-based cardiac neuromodulation therapy for hypertension
We assessed the feasibility of achieving acute, sustained blood pressure reductions through the use of cardiac pacing algorithms delivered via standard dual-chamber pacing based on introducing short atrio-ventricular (AV) delays (SAVD). Eighteen hypertensive subjects (57.3 ± 9.8 years old; 10 male and 8 female) with average initial systolic and diastolic blood pressures of 151.2 ± 17.6/92.2 ± 12.7 mmHg already scheduled to undergo an invasive electrophysiology procedure were included in this study. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - March 22, 2018 Category: Cardiology Authors: Bing Yang, Yue Wang, Fengxiang Zhang, Weizhu Ju, Hongwu Chen, Yuval Mika, Ricardo Aviv, Steven J. Evans, Daniel Burkhoff, Jie Wang, Minglong Chen Tags: Research Article Source Type: research

Age- and gender-dependent associations of blood pressure and serum sodium and potassium —renal and extrarenal regulations
Association analyses between blood pressure (BP) and serum sodium and potassium for 14,657 men and 16,977 women between ages 12 and 85 years show that responses of BP to serum sodium and potassium are age and gender dependent. The data were from the National Health and Nutrition Examination Survey between 2003 and 2014. Associations between serum sodium and BP are positive only for advanced age groups and for serum sodium level greater than 139 –140 mmol/L in less advanced groups. These positive associations can be explained by traditional renal-centered mechanism. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - March 22, 2018 Category: Cardiology Authors: Hongbing Sun, Michael Sun Tags: Research Article Source Type: research

Acute blood pressure effects of Programmable Hypertension Control (PHC) Therapy: rationale and evidence for the development of a durable treatment for hypertension
We assessed the feasibility of achieving acute, sustained blood pressure reductions through the use of cardiac pacing algorithms delivered via standard dual-chamber pacing based on short atrio-ventricular (AV) delay (SAVD). (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - March 22, 2018 Category: Cardiology Authors: Bing Yang, Yue Wang, Fengxiang Zhang, Weizhu Ju, Hongwu Chen, Yuval Mika, Ricardo Aviv, Steven J. Evans, Daniel Burkhoff, Jie Wang, Minglong Chen Tags: Research Article Source Type: research

Age and gender dependent associations of blood pressure and serum sodium and potassium-renal and extrarenal regulations
Association analyses between blood pressure (BP) and serum sodium and potassium for 14657 men and 16977 women between ages 12 and 85 show that responses of BP to serum sodium and potassium are age and gender dependent. The data were from the National Health and Nutrition Examination Survey between 2003 and 2014. Associations between serum sodium and BP are positive only for advanced age groups and for serum sodium level above 139 ∼140 mmol/l in less advanced groups. These positive associations can be explained by traditional renal-centered mechanism. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - March 22, 2018 Category: Cardiology Authors: Hongbing Sun, Michael Sun Tags: Research Article Source Type: research

Integrated flow-mediated vasodilation response predicts cardiovascular events in elderly patients with cardiovascular risk factors: the Japan Morning Surge Home Blood Pressure Study
The integrated flow-mediated vasodilation (FMD) response has been associated with cardiovascular risk factors, but the association between the integrated FMD response and subsequent cardiovascular events has been unclear. We enrolled 555 patients who had at least one cardiovascular risk factor (hypertension, dyslipidemia, diabetes or smoking). We measured the peak percentage change in diameter ( ΔFMD), and integrated FMD response calculated as the area under the dilation curve over a 120-second dilation period (FMD-AUC120). (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - March 22, 2018 Category: Cardiology Authors: Tomoyuki Kabutoya, Satoshi Hoshide, Kazuomi Kario Tags: Research Article Source Type: research

Epidemiologic observations guiding clinical application of a urinary peptidomic marker of diastolic left ventricular dysfunction
Hypertension, obesity and older age are major risk factors for left ventricular (LV) diastolic dysfunction (LVDD), but easily applicable screening tools in people at risk are lacking. We investigated whether HF1, a urinary biomarker consisting of 85 peptides, can predict over a 5-year time span mildly impaired diastolic LV function as assessed by echocardiography. In 645 White Flemish (50.5% women; 50.9 years [mean]), we measured HF1 by capillary electrophoresis coupled with mass spectrometry in 2005 –2010. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - March 22, 2018 Category: Cardiology Authors: Zhen-Yu Zhang, Esther Nkuipou-Kenfack, Wen-Yi Yang, Fang-Fei Wei, Nicholas Cauwenberghs, Lutgarde Thijs, Qi-Fang Huang, Ying-Mei Feng, Joost P. Schanstra, Tatiana Kuznetsova, Jens-Uwe Voigt, Peter Verhamme, Harald Mischak, Jan A. Staessen Tags: Research Article Source Type: research

Vascular toxicities with VEGF inhibitor therapies - Focus on Hypertension and Arterial Thrombotic Events
The vascular endothelial growth factor (VEGF) signalling pathway (VSP) fulfils a cardinal role in endothelial cells and its inhibition has profound cardiovascular impact. This is true not only for the normal vasculature but also for the tumor vasculature when VSP inhibitors are used as anti-angiogenic therapies. Generalized endothelial dysfunction predisposes to vasoconstriction, atherosclerosis, platelet activation, and thrombosis (arterial more than venous). All of these have been reported with VSP inhibitors and collectively give rise to vascular toxicities, the most concerning of which are arterial thromboembolic event...
Source: Journal of the American Society of Hypertension - March 22, 2018 Category: Cardiology Authors: Rhian M. Touyz, Sandra Herrmann, Joerg Herrmann Tags: Review Article Source Type: research

Mesenchymal stem cell –derived microvesicles alleviate pulmonary arterial hypertension by regulating renin-angiotensin system
In recent years, microvesicles (MVs) derived from mesenchymal stem cells (MSCs) have been proved to be able to improve the outcome of pulmonary arterial hypertension (PAH) in many respects, but the underlying mechanisms of it still remain unclear. Because the renin-angiotensin system (RAS) has been found to be closely related to PAH, the present study was designed to investigate whether the effect of MSC-derived MVs on PAH was correlated with RAS. MVs were isolated and purified from bone marrow MSCs. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - March 15, 2018 Category: Cardiology Authors: Zhenjun Liu, Jinghu Liu, Mengyuan Xiao, Junxian Wang, Feng Yao, Weikai Zeng, Liqin Yu, Yuejie Guan, Wenyan Wei, Zijian Peng, Kunpeng Zhu, Jin Wang, Zhongyuan Yang, Jixin Zhong, Jianying Chen Tags: Research Article Source Type: research

Mesenchymal stem cell derived microvesicles alleviate pulmonary arterial hypertension by regulating renin angiotensin system
In recent years, microvesicles derived from mesenchymal stem cells (MSCs) have been proved to be able to improve the outcome of pulmonary arterial hypertension (PAH) in many respects, but the underlying mechanisms of it still remain unclear. Since the renin angiotensin system (RAS) has been found to be closely related to PAH, the present study was designed to investigate whether the effect of MSC-derived microvesicles on PAH was correlated with RAS. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - March 15, 2018 Category: Cardiology Authors: Zhenjun Liu, Jinghu Liu, Mengyuan Xiao, Junxian Wang, Feng Yao, Weikai Zeng, Liqin Yu, Yuejie Guan, Wenyan Wei, Zijian Peng, Kunpeng Zhu, Jin Wang, Zhongyuan Yang, Jixin Zhong, Jianying Chen Tags: Research Article Source Type: research

Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians
This study assesses the association between baseline urinary cadmium and longitudinal changes in blood pressure in American Indian communities. Cadmium was measured in 3047 baseline urine samples from Strong Heart Study participants from three geographic areas. Longitudinal changes in blood pressure across three study visits (1989 –1999) were modeled using linear mixed models by baseline log urinary cadmium to creatinine ratio. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - March 9, 2018 Category: Cardiology Authors: Clare Oliver-Williams, Annie Green Howard, Ana Navas-Acien, Barbara V. Howard, Maria Tellez-Plaza, Nora Franceschini Tags: Research Article Source Type: research

Inverted U-shaped curve relationship between red blood cell distribution width and hypertension in a large health checkup population in China
This study was aimed at investigating the relationship between red blood cell distribution width (RDW) and hypertension in a large health check up population in China. A population of 302,527 subjects from Wuhu was enrolled in this cross-sectional health check up study between 2011 and 2016. They consisted of 126,369 women (41.78%) and 176,158 men (58.23%) with mean age of 46.9 ± 13.4 and 48.1 ± 13.7 years, respectively. The investigations included information on demographic characteristics, physical examination, and laboratory testing. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - March 9, 2018 Category: Cardiology Authors: Mingfei Jiang, Xiaojuan Zha, Zewei Wu, Xinying Zhu, Wenbo Li, Huan Wu, Jun Ma, Shuyi Wang, Yufeng Wen Tags: Controversies in Hypertension Source Type: research