Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate
Publication date: Available online 1 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Arun Kumar Awasthi, Lalit Kumar, Punit Tripathi, Madhava Golla, Cirandur Suresh Reddy, Pramod KumarAbstractPantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharmacopeia (USP) specified six impurities, viz.; impurities A, B, C, D, E and F, respectively for this active pharmaceutical in...
Source: Journal of Pharmaceutical Analysis - March 1, 2019 Category: Drugs & Pharmacology Source Type: research
Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices
Publication date: Available online 26 February 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): A.R. Pinho, A. Fortuna, A. Falcão, A.C. Santos, R. Seiça, C. Estevens, F. Veiga, A.J. RibeiroAbstractThe development of biotechnology-based active pharmaceutical ingredients, such as GLP-1 analogues, brought changes in type 2 diabetes treatment options. For better therapeutic efficiency, these active pharmaceutical ingredients require appropriate administration, without the development of adverse effects or toxicity. Therefore, it is required the development of several quantification methods for GLP-1 analogues product...
Source: Journal of Pharmaceutical Analysis - February 28, 2019 Category: Drugs & Pharmacology Source Type: research
Synthesis of highly fluorescent carbon dots from lemon and onion juices for determination of riboflavin in multivitamin/mineral supplements
Publication date: Available online 27 February 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Severino S. Monte-Filho, Stefani I.E. Andrade, Marcelo B. Lima, Mario C.U. AraujoAbstractIn this work, lemon and onion biomasses commonly found in street markets are for the first time used to develop a facile, fast and low-cost one-step microwave-assisted carbonization method for synthesis of highly fluorescent carbon dots (CDs). The structure and optical properties of CDs were investigated by TEM, XRD, XRF, UV–Vis, FTIR, and fluorescence spectroscopy. CDs displayed satisfactory optical proprieties, a high quantum yie...
Source: Journal of Pharmaceutical Analysis - February 28, 2019 Category: Drugs & Pharmacology Source Type: research
Analysis of pesticide residues in commercially available chenpi using a modified QuEChERS method and GC-MS/MS determination
In this study, different extraction solvents, redissolution solvents and adsorbents were tested according to the recovery and purification effect to obtain a modified QuEChERS method. The samples were extracted with acetonitrile. During the clean-up step, octadecyl-modified silica (C18) and graphitized carbon black (GCB) were selected, and aminopropyl (NH2) was used instead of primary secondary amine (PSA) because of its weaker ion exchange capacity which had little effect on the recovery of ditalimfos. Samples were quantified by matrix-matched calibration with internal standards. All pesticides showed good linearity in th...
Source: Journal of Pharmaceutical Analysis - February 1, 2019 Category: Drugs & Pharmacology Source Type: research
Editorial Board
Publication date: February 2019Source: Journal of Pharmaceutical Analysis, Volume 9, Issue 1Author(s): (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - January 26, 2019 Category: Drugs & Pharmacology Source Type: research
Compatibility of rubber stoppers for recombinant antitumor-antivirus protein injection by gas chromatography-mass spectrometry
Publication date: Available online 15 October 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Zhaorui Meng, Xun Gao, Haifeng Yu, Lan Zhang, Xiangyong Yu, Longshan ZhaoAbstractA simple, rapid, and sensitive gas chromatography-mass spectrometry (GC-MS) method was developed and validated for the simultaneous determination of two fatty acids, methyl hexadecanoate (MH) and methyl stearate (MS), to allow the evaluation of packaging-drug compatibility. The two migrants were quantified in selective ion-monitoring (SIM) mode, with limits of detection (LOD) of 0.0030 μg/mL and 0.0121 μg/mL. Linear calibration curves f...
Source: Journal of Pharmaceutical Analysis - January 17, 2019 Category: Drugs & Pharmacology Source Type: research
Application of activated carbon-decorated polyacrylonitrile nanofibers as an adsorbent in dispersive solid-phase extraction of fluoroquinolones from wastewater
Publication date: Available online 10 January 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): K. Mogolodi Dimpe, Philiswa N. NomngongoAbstractA cheap and simple sample preparation method, consisting of a dispersive solid-phase method and an adsorbent, activated carbon decorated PAN nanofibers, was employed and used for the extraction of antibiotics (ciprofloxacin, danofloxacin, and enrofloxacin) in wastewater. Electrospun PAN nanofibers that were decorated with activated carbon produced from waste tires were used as the solid phase and the antibiotics analyzed by using high-performance liquid chromatography. Param...
Source: Journal of Pharmaceutical Analysis - January 11, 2019 Category: Drugs & Pharmacology Source Type: research
Development of a fast and precise method for simultaneous quantification of the plga monomers lactic and glycolic acid by hplc
Publication date: Available online 11 January 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Marcel Pourasghar, Aljoscha Koenneke, Peter Meiers, Marc SchneiderAbstractPoly(lactide-co-glycolide acid) (PLGA) is an extraordinary well-described polymer and has excellent pharmaceutical properties like high biocompatibility and good biodegradability. Hence, it is one of the most used materials for drug delivery and biomedical systems, also being present in several US Food and Drug Administration-approved carrier systems and therapeutic devices. For both applications, the quantification of the polymer is inalienable. Du...
Source: Journal of Pharmaceutical Analysis - January 11, 2019 Category: Drugs & Pharmacology Source Type: research
Composition analysis and antioxidant activities of the Rhus typhina L. stem
Publication date: Available online 2 January 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Ting Liu, Zhaoqin Li, Ruiyun Li, Yue Cui, Yunli Zhao, Zhiguo YuAbstractThe present investigation reports the chemical composition of the Rhus typhina L. stem identified via mass spectrometry and NMR as gallic acid, 1-O-galloyl-β-D-glucose, tryptophan, scopolin, methyl gallate, fustin, quercetin, rutin, 1,2,3,4,6-penta-O-galloyl-β-D-glucose. The antioxidant properties and the chemical composition contents of the Rhus typhina L. stem grown in different regions in China were determined. To determine the antioxidant activity...
Source: Journal of Pharmaceutical Analysis - January 3, 2019 Category: Drugs & Pharmacology Source Type: research
Quality control of Semen Ziziphi Spinosae Standard Decoction based on determination of multi-components using TOF-MS/MS and UPLC-PDA technology
In conclusion, the method using UPLC combined with MS and PDA provided a novel way for the standardization and identification of SZS standard decoction, also offered a basis for qualitative analysis and quality assessment of the preparations for SZS standard decoction. (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - January 3, 2019 Category: Drugs & Pharmacology Source Type: research
Advancing USP compendial methods for fixed dose combinations: a case study of metoprolol tartrate and hydrochlorothiazide tablets
Publication date: Available online 28 December 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Qun XuAbstractThe current United States Pharmacopeia–National Formulary (USP–NF) includes more than 250 monographs of fixed dose combinations (FDCs), and some of them need to be updated due to incompleteness of impurity profiles and obsolescence of analytical methodologies. A case study of metoprolol tartrate and hydrochlorothiazide tablets is presented to summarize challenges encountered during the USP monograph modernization initiative of FDCs and to highlight an “adoption and adaptation” approach employed for ...
Source: Journal of Pharmaceutical Analysis - December 29, 2018 Category: Drugs & Pharmacology Source Type: research
New approaches to identification and characterization of tioconazole in raw material and in pharmaceutical dosage forms
Publication date: Available online 23 November 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Natalia L. Calvo, Vera A. Alvarez, María C. Lamas, Darío LeonardiAbstractTioconazole (TCZ), a broad-spectrum antifungal agent, has significant activity against Candida albicans and other Candida species, and therefore, it is indicated for the topical treatment of superficial mycoses. The main goal of this work is to report an exhaustive identification and characterization procedure to improve and facilitate the online quality control and continuous process monitoring of TCZ in bulk material and loaded in two different ...
Source: Journal of Pharmaceutical Analysis - December 22, 2018 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetic evaluation, molecular docking and in vitro biological evaluation of 1, 3, 4-oxadiazole derivatives as potent antioxidants and STAT3 inhibitors
Publication date: Available online 7 December 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Rashmin khanam, Iram I. Hejazi, Syed Shahabuddin, Abdul R. Bhat, Fareeda AtharAbstract1, 3, 4-Oxadiazole derivatives (4a-5f) were previously synthesized to investigate their anticancer properties. However, studies relating to their antioxidant potential and signal transducer and activator of transcription (STAT) inhibition have not been performed. We investigated previously synthesized 1, 3, 4-oxadiazole derivatives (4a-5f) for various radical scavenging properties using several in vitro antioxidant assays and also for di...
Source: Journal of Pharmaceutical Analysis - December 8, 2018 Category: Drugs & Pharmacology Source Type: research
Applications of microfluidic chip technology in pharmaceutical analysis: A review
Publication date: Available online 6 December 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Ping Cui, Sicen WangAbstractThe development of pharmaceutical analytical methods represents one of the most significant aspects of drug development. Recent advances in microfabrication and microfluidics could provide new approaches for drug analysis, including drug screening, active testing and the study of metabolism. Microfluidic chip technologies, such as lab-on-a-chip technology, three-dimensional (3D) cell culture, organs-on-chip and droplet techniques, have all been developed rapidly. Microfluidic chips coupled with...
Source: Journal of Pharmaceutical Analysis - December 6, 2018 Category: Drugs & Pharmacology Source Type: research
Controlled Delivery of Ibuprofen from Poly(vinyl alcohol)−Poly(ethylene glycol) Interpenetrating Polymeric Network Hydrogels
Publication date: Available online 30 November 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Subhraseema Das, Usharani SubuddhiAbstractHydrogels composed of poly(vinyl alcohol) (PVA) and poly(ethylene glycol) (PEG) were synthesized using glutaraldehyde as crosslinker and investigated for controlled delivery of the common anti-inflammatory drug, ibuprofen (IBF). To regulate the drug delivery, solid inclusion complexes (ICs) of IBF in β−cyclodextrin (β−CD) were prepared and added to the hydrogels. The ICs were prepared by the microwave irradiation method, which is environmentally more benign method. The form...
Source: Journal of Pharmaceutical Analysis - November 30, 2018 Category: Drugs & Pharmacology Source Type: research
