Metabolic profiling of four synthetic stimulants, including the novel indanyl-cathinone 5-PPDi, after human hepatocyte incubation
Publication date: Available online 28 December 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): David Fabregat-Safont, Marie Mardal, Juan V. Sancho, Félix Hernández, Kristian Linnet, María IbáñezAbstractSynthetic cathinones are new psychoactive substances that represent a health risk worldwide. For most of the 130 reported compounds, information about toxicology and/or metabolism is not available, which hampers their detection (and subsequent medical treatment) in intoxication cases. The principles of forensic analytical chemistry and the use of powerful analytical techniques are indispensable for stablishing ...
Source: Journal of Pharmaceutical Analysis - December 29, 2019 Category: Drugs & Pharmacology Source Type: research
Editorial Board
Publication date: December 2019Source: Journal of Pharmaceutical Analysis, Volume 9, Issue 6Author(s): (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - December 19, 2019 Category: Drugs & Pharmacology Source Type: research
Prediction of fibril formation by early-stage amyloid peptide aggregation
Publication date: Available online 13 December 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Jiaojiao Hu, Huiyong Sun, Haiping Hao, Qiuling ZhengAbstractAmyloid fibrils are found in systemic amyloidosis diseases such as Alzheimer's disease, Parkinson's disease, and type II diabetes. Currently, these diseases are diagnosed by observation of fibrils or plaques, which is an ineffective method for early diagnosis and treatment of disease. The goal of this study was to develop a simple and quick method to predict the possibility and speed of fibril formation before its occurrence. Oligomers generated from seven repre...
Source: Journal of Pharmaceutical Analysis - December 15, 2019 Category: Drugs & Pharmacology Source Type: research
Hollow fiber-based liquid phase microextraction followed by analytical instrumental techniques for quantitative analysis of heavy metal ions and pharmaceuticals
Publication date: Available online 12 December 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Wajid Ali Khan, Muhammad Balal Arain, Yadollah Yamini, Nasrullah Shah, Tasneem Gul Kazi, Stig Pedersen-Bjergaard, Mohammad TajikAbstractHollow-fiber liquid-phase microextraction (HF-LPME) and electromembrane extraction (EME) are miniaturized extraction techniques, and have been coupled with various analytical instruments for trace analysis of heavy metals, drugs and other organic compounds, in recent years. HF-LPME and EME provides high selectivity, efficient sample cleanup and enrichment, and reduces the consumption of ...
Source: Journal of Pharmaceutical Analysis - December 13, 2019 Category: Drugs & Pharmacology Source Type: research
An integrated spectroscopic strategy to trace the geographical origins of emblic medicines: Application for the quality assessment of natural medicines
Publication date: Available online 12 December 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Luming Qi, Furong Zhong, Yang Chen, Shengnan Mao, Zhuyun Yan, Yuntong MaAbstractEmblic medicine is a popular natural source in the world due to its outstanding healthcare and therapeutic functions. Our preliminary results indicated that the quality of emblic medicines might have an apparent regional variation. A rapid and effective geographical traceability system has not been designed yet. To trace the geographical origins so that their quality can be controlled, an integrated spectroscopic strategy including spectral p...
Source: Journal of Pharmaceutical Analysis - December 13, 2019 Category: Drugs & Pharmacology Source Type: research
Analysis of TRPA1 antagonist, A-967079, in plasma using high-performance liquid chromatography tandem mass-spectrometry
Publication date: Available online 13 December 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Obed A. Gyamfi, Nesta Bortey-Sam, Abigail B. Donkor, Carl W. White, Brian A. LogueAbstractThe noxious effects from exposure to toxic inhalation hazards (TIHs, such as isocyanates, nitroxides, etc.) are known to be triggered by the activation of transient receptor potential ankyrin 1 (TRPA1) ion channel. Antagonists of TRPA1 have shown near complete attenuation of the noxious effects from TIH exposure. One of the TRPA1 antagonists, (1E,3E)-1-(4-fluorophenyl)-2-methyl-1-pentene-3-one oxime (A-967079), has shown impressive ...
Source: Journal of Pharmaceutical Analysis - December 13, 2019 Category: Drugs & Pharmacology Source Type: research
Thermodynamics of clay – Drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography
Publication date: Available online 5 December 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Ana-Maria Totea, Juan Sabin, Irina Dorin, Karl Hemming, Peter R. Laity, Barbara R. Conway, Laura Waters, Kofi Asare-AddoAbstractAn understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great importance. Several characterisation techniques as well as isothermal calorimetry were utilized in investigating the adsorption process of a model cationic drug (diltiazem hydrochloride, DIL) onto a pharmaceutical clay system (magnesium aluminium silicate, MAS). X-ra...
Source: Journal of Pharmaceutical Analysis - December 6, 2019 Category: Drugs & Pharmacology Source Type: research
Comparing different domains of analysis for the characterisation of N-Glycans on monoclonal antibodies
In this study, ten different analytical workflows for N-glycan analysis were compared on four therapeutic monoclonal antibodies. While observing good comparability between the quantitative results generated, it was possible to appreciate the advantages and disadvantages of each technique and to summarise all the observations to guide the choice of the most appropriate analytical workflow according to application and the desired depth of data generated.Graphical abstract (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - November 30, 2019 Category: Drugs & Pharmacology Source Type: research
GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine
Publication date: Available online 28 November 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Olga Begou, Kathrin Drabert, Georgios Theodoridis, Dimitrios TsikasAbstractAcetazolamide (molecular mass (MM), 222) belongs to the class of sulfonamides (R-SO2-NH2) and is one of the strongest pharmacological inhibitors of carbonic anhydrase activity. Acetazolamide is excreted unchanged in the urine. Here, we report on the development, validation and biomedical application of a stable-isotope dilution GC-MS method for the reliable quantitative determination of acetazolamide in human urine. The method is based on evaporat...
Source: Journal of Pharmaceutical Analysis - November 29, 2019 Category: Drugs & Pharmacology Source Type: research
Metabonomic analysis of potential plasma biomarkers in pyrexia rats after treatment with Gegenqinlian decoction, aspirin and itraconazole by UHPLC-FT-ICR-MS
Publication date: Available online 27 November 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Ting Liu, Ruiyun Li, Yue Cui, Zhiguo Yu, Yunli ZhaoAbstractA metabonomic approach involving an ultrahigh-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) was used to investigate the changes in the endogenous metabolites in the plasma of rats with yeast-induced pyrexia treated with Gegenqinlian decoction (GQLD), aspirin and itraconazole. The differences in the small molecule profiles of treatment using Traditional Chinese medicine, etiological tr...
Source: Journal of Pharmaceutical Analysis - November 27, 2019 Category: Drugs & Pharmacology Source Type: research
Comparative analysis of constitutes and metabolites for traditional Chinese medicine using IDA and SWATH data acquisition modes on LC-Q-TOF MS
Publication date: Available online 19 November 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Dian Kang, Qingqing Ding, Yangfan Xu, Xiaoxi Yin, Huimin Guo, Tengjie Yu, He Wang, Wenshuo Xu, Guangji Wang, Yan LiangAbstractIdentification of components and metabolites of traditional Chinese medicines (TCMs) employing liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF MS) techniques with information-dependent acquisition (IDA) approaches is more and more frequent. A current drawback of IDA-MS is that the complexity of a sample might prevent important compounds from being triggered in IDA settin...
Source: Journal of Pharmaceutical Analysis - November 20, 2019 Category: Drugs & Pharmacology Source Type: research
Nuclear magnetic resonance based structure of the protoberberine alkaloid coralyne and its self-association by spectroscopy techniques
Publication date: Available online 26 September 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Kumar Padmapriya, Ritu BarthwalAbstractCoralyne is an important alkaloid due to its anti-cancer and other medicinal properties. It targets DNA in cells and acts as human topoisomerase-I poison, telomerase inhibitor and nucleic acid intercalator. It has high tendency to undergo self-association, which is a matter of concern for therapeutic applications. The understanding of its interaction with DNA requires precise knowledge of chemical shifts in Nuclear Magnetic Resonance (NMR) spectra besides self-association. The pres...
Source: Journal of Pharmaceutical Analysis - November 17, 2019 Category: Drugs & Pharmacology Source Type: research
Isoflavones influencing on pharmacokinetic profiles of main iridoids from Gardeniae Fructus in rats
Publication date: Available online 14 November 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Ruirui Chang, Jialin Liu, Taohong Huang, Qiang Li, Jun Wen, Weidong Chen, Tingting ZhouAbstractGardeniae Fructus (GF) and Semen Sojae Praeparatum (SSP) are both medicine food homologies, and widely used in Chinese clinical prescriptions together. The research investigated the pharmacokinetics of four iridoids in normal rats and isolfavones-feeding rats, which were administrated with isolfavones from SSP for 7, 14, 21 and 28 consecutive days. A validated LC-MS/MS method was developed for determining shanzhiside, genipin-1...
Source: Journal of Pharmaceutical Analysis - November 14, 2019 Category: Drugs & Pharmacology Source Type: research
Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid
Publication date: Available online 6 November 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Ningning Zheng, Yu Gu, Ying Hong, Lili Sheng, Linlin Chen, Feng Zhang, Zimiao Weng, Weidong Zhang, Zean Zhang, Wei Jia, Houkai LiAbstractLiver injury caused by acetaminophen (AP) overdose is a leading public health problem. Although AP-induced liver injury is well recognized as the formation of N-acetyl-p-benzoquinone (NAPQI), a toxic metabolite of AP, resulting in cell damage, emerging evidence indicates that AP-induced liver injury is also associated with gut microbiota. However, the gut microbiota-involved mechanism re...
Source: Journal of Pharmaceutical Analysis - November 8, 2019 Category: Drugs & Pharmacology Source Type: research
Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification
Publication date: Available online 5 November 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Armel Jackson Seukep, Victor Kuete, Lutfun Nahar, Satyajit D. Sarker, Mingquan GuoAbstractThe upsurge of multiple drug resistance (MDR) bacteria substantially diminishes the effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The major factor in MDR is efflux pump-mediated resistance. A unique pump can make bacteria withstanding to a wide range of structurally diverse compounds. Therefore, their inhibition is a promising route to eliminate resistance phenomenon in bacteria. Phyto...
Source: Journal of Pharmaceutical Analysis - November 7, 2019 Category: Drugs & Pharmacology Source Type: research
