Carbon nanotubes: Evaluation of toxicity at biointerfaces
Publication date: Available online 25 April 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Debashish Mohanta, Soma Patnaik, Sanchit Sood, Nilanjan DasAbstractCarbon nanotubes (CNTs) are a class of carbon allotropes with interesting properties that make them productive materials for usage in various disciplines of nanotechnology such as in electronics equipments, optics and therapeutics. They exhibit distinguished properties viz., strength, and high electrical and heat conductivity. Their uniqueness can be attributed due to the bonding pattern present between the atoms which are very strong and also exhibit high e...
Source: Journal of Pharmaceutical Analysis - April 26, 2019 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetics and enterohepatic circulation of jervine, an antitumor steroidal alkaloid from Veratrum nigrum in rats
Publication date: Available online 25 April 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Bingjing Zheng, Caihong Wang, Wenwen Song, Xiaoxia Ye, Zheng XiangAbstractJervine is a novel steroidal alkaloid from Veratrum nigrum L. exhibiting both antitumor effect and potential toxicity. The aim of study was to characterize the pharmacokinetic behaviors and enterohepatic circulation of jervine in rats. A rapid and simple ultra-high performance liquid chromatography-tandem mass spectrometric method was developed and validated for quantification of jervine and alpinetin (internal standard) in rat plasma. After extractio...
Source: Journal of Pharmaceutical Analysis - April 25, 2019 Category: Drugs & Pharmacology Source Type: research
Editorial Board
Publication date: April 2019Source: Journal of Pharmaceutical Analysis, Volume 9, Issue 2Author(s): (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - April 12, 2019 Category: Drugs & Pharmacology Source Type: research
Temperature and eluent composition effects on enantiomer separation of carvedilol by high‐performance liquid chromatography on immobilized amylose-based chiral stationary phases
Publication date: Available online 4 April 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Cristina Panella, Rosella Ferretti, Adriano Casulli, Roberto CirilliAbstractCarvedilol is a chiral drug with potent antihypertensive and antianginal activity. Although it is clinically used as a racemic mixture, its enantiomers show different pharmacokinetic and pharmacodynamic profiles. Here, the direct chiral separation of racemic drug by high performance liquid chromatography using two immobilized-type amylose-based chiral stationary phases is presented. Some chromatographic parameters, such as retention and selectivity, ...
Source: Journal of Pharmaceutical Analysis - April 5, 2019 Category: Drugs & Pharmacology Source Type: research
Voltammetric sensor based on cobalt-poly(methionine)-modified glassy carbon electrode for determination of estriol hormone in pharmaceuticals and urine
Publication date: Available online 5 April 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Eliziana S. Gomes, Fernando R.F. Leite, Bruno R.L. Ferraz, Henrique A.J.L. Mourão, Andréa R. MalaguttiAbstractA voltammetric sensor based on the electropolymerization of cobalt-poly(methionine) (Co-poly(Met)) on a glassy carbon electrode (GCE) was developed and applied for the determination of estriol by differential pulse voltammetry (DPV) for the first time. The electrochemical properties of the Co-poly(Met)/GCE were analysed by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Scanning electron m...
Source: Journal of Pharmaceutical Analysis - April 5, 2019 Category: Drugs & Pharmacology Source Type: research
Highly sensitive simultaneous electrochemical determination of myricetin and rutin via solid phase extraction on a ternary Pt@r-GO@MWCNTs nanocomposite
Publication date: Available online 22 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Satar Tursynbolat, Yrysgul Bakytkarim, Jianzhi Huang, Lishi WangAbstractThe simultaneous electrochemical determination of myricetin and rutin remains a challenge due to their indistinguishable potentials. To solve this problem, we constructed a ternary platinum nanoparticle, reduced graphene oxide, multi-walled carbon nanotubes (Pt@r-GO@MWCNTs) nanocomposite via a facile one-pot synthetic method. Under the optimized conditions, the ternary Pt@r-GO@MWCNTs nanocomposite exhibited good electrocatalytic activity toward myriceti...
Source: Journal of Pharmaceutical Analysis - March 23, 2019 Category: Drugs & Pharmacology Source Type: research
Primmorph extracts and mesohyls of marine sponges inhibit proliferation and migration of hepatocellular carcinoma cells in vitro
Publication date: Available online 22 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Hanaa Rady, Sohair Salem, Mohamed Ez El-ArabAbstractCancer recurrence and severe side effects of currently being used chemotherapeutic agents reduce their clinical efficacy. Thus, there is a constant need to develop alternative anticancer drugs. Sustainable supply is an important challenge facing marine-based drug discovery. Primmorph, a 3D cell culture system, could provide a sustainable source to produce metabolites for anticancer drugs from marine sponges. In the present work, the anticancer activity of primmorph extract...
Source: Journal of Pharmaceutical Analysis - March 23, 2019 Category: Drugs & Pharmacology Source Type: research
Interaction of repaglinide with bovine serum albumin: Spectroscopic and molecular docking approaches
Publication date: Available online 16 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Suma K. Pawar, J. SeetharamappaAbstractRepaglinide (RPG) regulates the amount of glucose by stimulating the pancreas to release insulin in the blood. In view of its biological importance, we have examined the interaction between RPG and a model protein, bovine serum albumin (BSA) employing various spectroscopic, electrochemical and molecular docking methods. Fluorescence spectra of BSA were recorded in the presence and absence of RPG in phosphate buffer of pH 7.4. Fluorescence intensity of BSA was decreased upon the additio...
Source: Journal of Pharmaceutical Analysis - March 17, 2019 Category: Drugs & Pharmacology Source Type: research
Application of microfluidic chip technology in pharmaceutical analysis: A review
Publication date: Available online 6 December 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Ping Cui, Sicen WangAbstractThe development of pharmaceutical analytical methods represents one of the most significant aspects of drug development. Recent advances in microfabrication and microfluidics could provide new approaches for drug analysis, including drug screening, active testing and the study of metabolism. Microfluidic chip technologies, such as lab-on-a-chip technology, three-dimensional (3D) cell culture, organs-on-chip and droplet techniques, have all been developed rapidly. Microfluidic chips coupled with...
Source: Journal of Pharmaceutical Analysis - March 16, 2019 Category: Drugs & Pharmacology Source Type: research
Anticancer potential of metabolic compounds from marine actinomycetes isolated from Lagos Lagoon sediment
This study is the first to reveal the anticancer potential of actinomycetes from Lagos Lagoon, which could be exploited for therapeutic purposes. (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - March 16, 2019 Category: Drugs & Pharmacology Source Type: research
Preparation of polypyrrole/nanosilica composite for solid-phase microextraction of bisphenol and phthalates migrated from containers to eye drops and injection solutions
Publication date: Available online 15 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Mehdi Ansari Dogaheh, Mansoureh BehzadiAbstractThis paper describes the electrodeposition of polyphosphate-doped polypyrrole/nanosilica nanocomposite coating on steel wire for direct solid-phase microextraction of bisphenol A and five phthalates. Influencing parameters on the extraction efficiency and morphology of the nanocomposite such as deposition potential, concentration of pyrrole and polyphosphate, deposition time and the nanosilica amount were optimized. Under the optimized conditions, characterization of the nanoco...
Source: Journal of Pharmaceutical Analysis - March 16, 2019 Category: Drugs & Pharmacology Source Type: research
Effect of an extraction solvent in the antioxidant quality of Pinus densiflora needle extract
Publication date: Available online 15 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Thamizhiniyan Venkatesan, Young-Woong Choi, Young-Kyoon KimAbstractPinus densiflora needle extract (PDNE) is widely reported to have many pharmacological activities including an antioxidant. However, the solvent system used for extraction greatly affects its antioxidant quality. Hence, in the present study, we investigated the effect of a different ratio (volume/volume) of ethanol to water (0–100%) in the extraction of PDNE with potent antioxidant capacity. The chemical assays, 2,2-diphenyl-1 picrylhydrazyl (DPPH), and 2,...
Source: Journal of Pharmaceutical Analysis - March 16, 2019 Category: Drugs & Pharmacology Source Type: research
Development and validation of a LC-MS/MS method for tyrphostin A9
Publication date: Available online 8 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Lyndsey F. Meyer, Dhaval K. ShahAbstractHere we have presented a sensitive and selective LC-MS/MS method for the quantification of tyrphostin A9, which is a selective tyrosine kinase inhibitor for platelet derived growth factor tyrosine kinase and has been investigated in vitro as a potent oxidative phosphorylation uncoupler. The analytical method was developed for three biological matrices: cell culture media, adipose cell lysate, and mouse plasma. For each matrix the limit of detection and the limit of quantification was f...
Source: Journal of Pharmaceutical Analysis - March 9, 2019 Category: Drugs & Pharmacology Source Type: research
Essential oils of Origanum compactum induce membrane permeability, disturb cell membrane, and suppress quorum-sensing phenotype in bacteria
Publication date: Available online 7 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Abdelhakim Bouyahya, Jamal Abrini, Nadia Dakka, Youssef BakriAbstractThe aim of this study was the investigation of antibacterial activity of Origanum compactum essential oils at three phenological stages on Escherichia coli and Bacillus subtilis. The antibacterial activity was evaluated using the agar-well diffusion assay. The MIC and MBC values were determined using the micro-dilution assay. The investigation of the antibacterial action was carried out by the evaluation of the effect of O. compactum essential oils on the a...
Source: Journal of Pharmaceutical Analysis - March 9, 2019 Category: Drugs & Pharmacology Source Type: research
Performance comparison of chlorinated chiral stationary phases in supercritical fluid chromatography for separation of selected pyrrolidone derivatives
Publication date: Available online 5 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Anca-Elena Dascalu, Alina Ghinet, Muriel Billamboz, Emmanuelle LipkaAbstractThe effect of two chlorinated chiral stationary phases namely Lux Cellulose-2 and Lux i-Cellulose-5, flow-rate, percentage of co-solvent and chemical structures of the compounds on retention and resolution were studied within this article. In this work a backpressure of 150 bar, a temperature of 40 °C and 10% of methanol as co-solvent were chosen as operating conditions. The optimum flow-rate was equal to 2 mL/min. The percentage of co-solvent...
Source: Journal of Pharmaceutical Analysis - March 6, 2019 Category: Drugs & Pharmacology Source Type: research
