Irbesartan desmotropes: Solid-state characterization, thermodynamic study and dissolution properties
Publication date: Available online 10 July 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Andrea Mariela Araya-Sibaja, Carlos Eduardo Maduro Campos, Cinira Fandaruff, José Roberto Vega-Baudrit, Teodolito Guillén-Girón, Mirtha Navarro Hoyos, Silvia Lucía CuffiniAbstractIrbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the solid-state, both tautomers can be isolated as crystal forms A (1H-tautomer) and B (2H-tautomer). Studies have reported that IBS is ...
Source: Journal of Pharmaceutical Analysis - July 10, 2019 Category: Drugs & Pharmacology Source Type: research
Temperature and eluent composition effects on enantiomer separation of carvedilol by high-performance liquid chromatography on immobilized amylose-based chiral stationary phases
Publication date: Available online 4 April 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Cristina Panella, Rosella Ferretti, Adriano Casulli, Roberto CirilliAbstractCarvedilol is a chiral drug with potent antihypertensive and antianginal activities. Although it is clinically used as a racemic mixture, its enantiomers show different pharmacokinetic and pharmacodynamic profiles. Here, the direct chiral separation of racemic drug by high performance liquid chromatography using two immobilized-type amylose-based chiral stationary phases is presented. Some chromatographic parameters, such as retention and selectivity...
Source: Journal of Pharmaceutical Analysis - June 27, 2019 Category: Drugs & Pharmacology Source Type: research
Determination of iohexol by capillary blood microsampling and UHPLC-MS/MS
This study proposes and evaluates a new LC-MS/MS method for the iohexol determination from capillary blood, prelevated using volumetric absorbative microsampling systems (VAMS). As an alternative to VAMS a brand new HemaPEN® device for micro-prelevation was also tested.A new high throughput sample preparation protocol adapted for Iohexol quantification from whole blood VAMS samples was developed. The medium term stability study of iohexol in dried whole blood VAMS samples that was conducted showed a good stability of this molecule for up to 12 days.By collecting only 10 μL of blood, iohexol can be analyzed from dried w...
Source: Journal of Pharmaceutical Analysis - June 27, 2019 Category: Drugs & Pharmacology Source Type: research
Comparative analysis of twenty-five compounds in different parts of Astragalus membranaceus var. mongholicus and Astragalus membranaceus by UPLC-MS/MS
Publication date: Available online 25 June 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Yuan Li, Sheng Guo, Yue Zhu, Hui Yan, Da-wei Qian, Han-qing Wang, Jian-qiang Yu, Jin-ao DuanAbstractAs a traditional Chinese medicine, the root of Astragalus membranaceus var. mongholicus (AMM) or A. membranaceus (AM) has been widely used in China and other Asian countries for thousands of years. Till now, the flavonoids, phenolic acids and saponins are considered as the main active components contributed to their therapeutic effect in these plants. In order to clarify the distribution and contents of these compounds in diff...
Source: Journal of Pharmaceutical Analysis - June 26, 2019 Category: Drugs & Pharmacology Source Type: research
Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples
Publication date: Available online 20 June 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Forough Karami, Sara Ranjbar, Younes Ghasemi, Monica NegahdaripourAbstractMethotrexate (MTX) is a folate antagonist drug used for several diseases, such as cancers, various malignancies, rheumatoid arthritis (RA) and inflammatory bowel disease. Due to its structural features, including the presence of two carboxylic acid groups and its low native fluorescence, there are some challenges to develop analytical methods for its determination. MTX is metabolized to 7-hydroxymethotrexate (7-OH-MTX), 2,4-diamino-N10-methylpteroic ac...
Source: Journal of Pharmaceutical Analysis - June 21, 2019 Category: Drugs & Pharmacology Source Type: research
Editorial Board
Publication date: June 2019Source: Journal of Pharmaceutical Analysis, Volume 9, Issue 3Author(s): (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - June 20, 2019 Category: Drugs & Pharmacology Source Type: research
Elucidating the interaction of kansui and licorice by comparative plasma/tissue metabolomics and a heatmap with relative fold change
Publication date: Available online 1 June 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Yan-Yan Chen, Juan Shen, Yu-Ping Tang, Jin-Gao Yu, Jing Wang, Shi-Jun Yue, Jie Yang, Jia-Qian Chen, Li-Mei Feng, Zhen-Hua Zhu, Wei-Wei Tao, Li Zhang, Jin-Ao DuanAbstractAlthough compatibility is highly advocated in traditional Chinese medicine (TCM), inappropriate combination of some herbs may reduce the therapeutic action and even produce toxic effects. Kansui and licorice, one of TCM “Eighteen Incompatible Medicaments”, are the most representative cases of improper herbal combination, which may still be applied simultan...
Source: Journal of Pharmaceutical Analysis - June 1, 2019 Category: Drugs & Pharmacology Source Type: research
Research advances in the detection of miRNA
Publication date: Available online 25 May 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Jiawei Ye, Mingcheng Xu, Xueke Tian, Sheng Cai, Su ZengAbstractMicroRNAs (miRNAs) are a family of endogenous, small (approximately 22 nucleotides in length), noncoding, functional RNAs. With the development of molecular biology, the research of miRNA biological function has attracted significant interest, as abnormal miRNA expression is identified to contribute to serious human diseases such as cancers. Traditional methods for miRNA detection do not meet current demands. In particular, nanomaterial-based methods, nucleic acid...
Source: Journal of Pharmaceutical Analysis - May 26, 2019 Category: Drugs & Pharmacology Source Type: research
Essential oils of Origanum compactum increase membrane permeability, disturb cell membrane integrity, and suppress quorum-sensing phenotype in bacteria
Publication date: Available online 7 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Abdelhakim Bouyahya, Jamal Abrini, Nadia Dakka, Youssef BakriAbstractThe aim of this study was to investige antibacterial activity of Origanum compactum essential oils collected at three phenological stages on Escherichia coli and Bacillus subtilis. The antibacterial activity was evaluated using the agar-well diffusion assay. The MIC and MBC values were determined using the micro-dilution assay. The investigation of the antibacterial action was carried out by the evaluation of the effect of O. compactum essential oils on th...
Source: Journal of Pharmaceutical Analysis - May 24, 2019 Category: Drugs & Pharmacology Source Type: research
Rapid identification of chemical profile in Gandou decoction by UPLC-Q-TOF-MSE coupled with novel informatics UNIFI platform
This study developed a rapid method for characterizing the chemical constituents in GDD, which could not only be used for chemical standardization and quality control, but also be helpful for further research of GDD in vivo. (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - May 16, 2019 Category: Drugs & Pharmacology Source Type: research
Development and validation of an LC-MS/MS method for tyrphostin A9
Publication date: Available online 8 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Lyndsey F. Meyer, Dhaval K. ShahAbstractHere we have presented a sensitive and selective LC-MS/MS method for the quantification of tyrphostin A9, which is a selective inhibitor for platelet derived growth factor receptor tyrosine kinase and has been investigated in vitro as a potent oxidative phosphorylation uncoupler. The murine analytical method was developed for three biological matrices: cell culture media, adipose 3T3-L1 cell lysate, and mouse plasma. For each matrix the limit of detection and the limit of quantificatio...
Source: Journal of Pharmaceutical Analysis - May 15, 2019 Category: Drugs & Pharmacology Source Type: research
Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate
Publication date: Available online 1 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Arun Kumar Awasthi, Lalit Kumar, Punit Tripathi, Madhava Golla, Cirandur Suresh Reddy, Pramod KumarAbstractPantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharmacopoeia (USP) specify six impurities, viz.; impurities A, B, C, D, E and F, respectively for its active pharmaceutical ingr...
Source: Journal of Pharmaceutical Analysis - May 14, 2019 Category: Drugs & Pharmacology Source Type: research
Effect of an extraction solvent on the antioxidant quality of Pinus densiflora needle extract
Publication date: Available online 15 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Thamizhiniyan Venkatesan, Young-Woong Choi, Young-Kyoon KimAbstractPinus densiflora needle extract (PDNE) is widely reported to have many pharmacological activities including antioxidant potential. However, the solvent system used for extraction greatly affects its antioxidant quality. Hence, in the present study, we investigated the effect of a different ratio (vol/vol) of ethanol to water (0–100%) in the extraction of PDNE with potent antioxidant capacity. The chemical assays, 2,2-diphenyl-1 picrylhydrazyl (DPPH) and 2,...
Source: Journal of Pharmaceutical Analysis - May 14, 2019 Category: Drugs & Pharmacology Source Type: research
Advances in capillary electro-chromatography
Publication date: Available online 11 May 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Zhenkun Mao, Zilin ChenAbstractCapillary electrochromatography (CEC) is a micro-scale separation technique which is a hybrid between capillary electrophoresis (CE) and liquid chromatography (LC). CEC can be performed in packed, monolithic and open-tubular columns. In recent three years (from 2016 to 2018), enormous attention for CEC is the development of novel stationary phases. This review mainly covers the development of novel stationary phases for open-tubular and monolithic columns. In particular, some biomaterials attrac...
Source: Journal of Pharmaceutical Analysis - May 12, 2019 Category: Drugs & Pharmacology Source Type: research
Simultaneous determination of amino acids in different teas using supercritical fluid chromatography coupled with single quadrupole mass spectrometry
In this study, a novel method based on supercritical fluid chromatography coupled with mass spectrometry (SFC-MS) was developed to simultaneously determine 11 amino acids in different types of tea (green teas, Oolong tea, black tea and Pu-erh tea). The separation Conditions for the analysis of the selected amino acids including the column type, temperature and backpressure as well as the type of additive, were carefully optimized. The best separation of the 11 amino acids was obtained by adding water (5%, v/v) and trifluoroacetic acid (0.4%, v/v) to the organic modifier (methanol). Finally, the developed SFC-MS method was ...
Source: Journal of Pharmaceutical Analysis - May 11, 2019 Category: Drugs & Pharmacology Source Type: research
