TGA/Chemometrics addressing innovative preparation strategies for functionalized carbon nanotubes
Publication date: Available online 27 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Roberta Risoluti, Giuseppina Gullifa, Elena Carcassi, Andrea Masotti, Stefano Materazzi (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - February 28, 2020 Category: Drugs & Pharmacology Source Type: research
Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analyses at effective plasma concentrations utilizing UPLC-MS/MS
Publication date: Available online 22 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E. HaefeliAbstractExenatide is the first approved glucagon-like peptide 1 receptor agonist subcutaneously or intramuscularly injected for the treatment of type 2 diabetes mellitus. Typical therapeutic plasma concentrations are in the low pg/mL range therefore requiring ultra-sensitive quantification. To enable the accurate evaluation of pharmacokinetic studies, we established a UPLC-MS/MS assay with a lower limit of quantification (LLOQ) of 5 pg/mL (1.2 pM) using 200 ...
Source: Journal of Pharmaceutical Analysis - February 23, 2020 Category: Drugs & Pharmacology Source Type: research
Thermodynamics of clay–drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography
Publication date: February 2020Source: Journal of Pharmaceutical Analysis, Volume 10, Issue 1Author(s): Ana-Maria Totea, Juan Sabin, Irina Dorin, Karl Hemming, Peter R. Laity, Barbara R. Conway, Laura Waters, Kofi Asare-AddoAbstractAn understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great importance. Several characterisation techniques as well as isothermal calorimetry were utilized in investigating the adsorption process of a model cationic drug (diltiazem hydrochloride, DIL) onto a pharmaceutical clay system (magnesium aluminium silicate, MAS). X-r...
Source: Journal of Pharmaceutical Analysis - February 21, 2020 Category: Drugs & Pharmacology Source Type: research
Determination of l-norvaline and l-tryptophan in dietary supplements by nano-LC using an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine-silica hybrid monolithic column
Publication date: February 2020Source: Journal of Pharmaceutical Analysis, Volume 10, Issue 1Author(s): Dongsheng Xu, Elena Sánchez-López, Qiqin Wang, Zhengjin Jiang, María Luisa MarinaAbstractAn analytical methodology based on an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine (MQD)-silica hybrid monolithic column was developed for the enantioseparation of 9-fluorenylmethoxycarbonyl (FMOC) derivatized amino acids by nano-liquid chromatography. The mobile phase was optimized including the apparent pH, content of ACN, and concentration of the buffer to obtain a satisfactory enantioresolution performance. 27...
Source: Journal of Pharmaceutical Analysis - February 21, 2020 Category: Drugs & Pharmacology Source Type: research
Editorial Board
Publication date: February 2020Source: Journal of Pharmaceutical Analysis, Volume 10, Issue 1Author(s): (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - February 21, 2020 Category: Drugs & Pharmacology Source Type: research
Biophysical interactions between silver nanoparticle-albumin interface and curcumin
Publication date: Available online 20 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Vinod D. Jaiswal, P.M. DongreAbstractActive targeted drug delivery methods facilitate effective uptake of functionalized nanoparticles through receptor-mediated transcytosis. In recent years, albumin-nanoparticle interaction has been critically examined so that this functionalized nanoparticle can be efficiently loaded with drugs. The present investigation aims at understanding the adsorption of Bovine Serum Albumin (BSA) on Silver Nanoparticle (SNP) surface, preparation of soft conjugates (SC) and hard conjugates (HC) o...
Source: Journal of Pharmaceutical Analysis - February 21, 2020 Category: Drugs & Pharmacology Source Type: research
Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples
Publication date: Available online 20 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Ahmad Reza Bagheri, Mehrorang GhaediAbstractThe aim of this study is a present of a simple solvothermal synthesis approach for preparation of Cu-based magnetic metal organic framework (MMOF) and subsequently its application as sorbent for ultrasound assisted magnetic solid phase extraction (UAMSPE) of ampicillin (AMP) from cow milk samples prior to high performance liquid chromatography-Ultraviolet (HPLC-UV) determination. Characteristics of prepared MMOF was fully investigated by different techniques which showed the ex...
Source: Journal of Pharmaceutical Analysis - February 21, 2020 Category: Drugs & Pharmacology Source Type: research
Three-dimensional aspects of formulation excipients in drug discovery: A critical assessment on orphan excipients, matrix effects and drug interactions
Publication date: Available online 19 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Vijayabhaskar Veeravalli, Hanumanth Srikanth Cheruvu, Pratima Srivastava, Lakshmi Mohan Vamsi MadgulaAbstractFormulation/pharmaceutical excipients play a major role in formulating drug candidates, with the objectives of ease of administration, targeted delivery and complete availability. Many excipients used in pharmaceutical formulations are orphanized in preclinical drug discovery. These orphan excipients could enhance formulatability of highly lipophilic compounds. Additionally, they are safe in preclinical species wh...
Source: Journal of Pharmaceutical Analysis - February 19, 2020 Category: Drugs & Pharmacology Source Type: research
Solid and liquid state characterization of tetrahydrocurcumin using XRPD, FT-IR, DSC, TGA, LC-MS, GC-MS, NMR and its biological activities
Publication date: Available online 15 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Mahendra Kumar Trivedi, Parthasarathi Panda, Kalyan Kumar Sethi, Mayank Gangwar, Sambhu Charan Mondal, Snehasis JanaAbstractTetrahydrocurcumin (THC) is one of the major metabolites of curcumin (CUR), an ancient bioactive natural polyphenolic compound. This research article described both the solid and liquid state characterization of THC using advanced spectroscopic and thermo-analytical techniques. Anti-inflammatory, anti-oxidant, and neuroprotective activities of THC were investigated using in vitro cell lines. Liquid ...
Source: Journal of Pharmaceutical Analysis - February 16, 2020 Category: Drugs & Pharmacology Source Type: research
Inhibition of cell proliferation and migration by Oroxylum indicum extracts on breast cancer cells via Rac1 modulation
In this study, we investigated how Oroxylum indicum leaf and fruit extracts affect the viability and migration of MCF-7 breast cancer cells and the mechanisms of action responsible for these effects. MCF-7 cells treated with the extracts were examined using the sulforhodamine B, colony formation and caspase 3 activity assays, and by western blotting. O. indicum extracts were found to inhibit MCF-7 cell growth in a concentration- and time-dependent manner, with 48 h IC50 values of 57.02 ± 2.85 μg/mL and 131.3 ± 19.2 μg/mL for leaf and fruit extracts, respectively. Further, the O. indicum leaf extract c...
Source: Journal of Pharmaceutical Analysis - February 13, 2020 Category: Drugs & Pharmacology Source Type: research
Synthesis and electrochemical properties of environmental free l-glutathione grafted graphene oxide/ZnO nanocomposite for highly selective piroxicam sensing
Publication date: Available online 6 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): N. Dhanalakshmi, T. Priya, S. Thennarasu, S. Sivanesan, N. ThinakaranAbstractA simple and reliable strategy was proposed to engineer the glutathione grafted graphene oxide/ZnO nanocomposite (glutathione-GO/ZnO) as electrode material for the high-performance piroxicam sensor. The prepared glutathione-GO/ZnO nanocomposite was well characterized by X-ray Diffraction, Fourier Transform Infrared Spectrum, X-ray Photoelectron Spectroscopy, Field Emission Scanning Electron Microscopy, Cyclic Voltammetry, Electrochemical Impedanc...
Source: Journal of Pharmaceutical Analysis - February 7, 2020 Category: Drugs & Pharmacology Source Type: research
Drug target discovery by magnetic nanoparticles coupled mass spectrometry
Publication date: Available online 5 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Dandan Xia, Baoling Liu, Xiaowei Xu, Ya Ding, Qiuling ZhengAbstractDrug target discovery is the basis of drug screening. It elucidates the cause of disease and the mechanism of drug action, which is the essential of drug innovation. Target discovery performed in biological systems is complicated as proteins are in low abundance and endogenous compounds may interfere with drug binding. Therefore, methods to track drug-target interactions in biological matrices are urgently required. In this work, a Fe3O4 nanoparticle-based...
Source: Journal of Pharmaceutical Analysis - February 5, 2020 Category: Drugs & Pharmacology Source Type: research
An ultra-robust fingerprinting method for quality assessment of traditional Chinese medicine using multiple reaction monitoring mass spectrometry
Publication date: Available online 16 January 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Zhenhao Li, Xiaohui Zhang, Jie Liao, Xiaohui Fan, Yiyu ChengAbstractChromatographic fingerprinting has been perceived as an essential tool for assessing quality and chemical equivalence of traditional Chinese medicine. However, this pattern-oriented approach still has some weak points in terms of chemical coverage and robustness. In this work, we proposed a multiple reaction monitoring (MRM)-based fingerprinting method in which approximately 100 constituents were simultaneously detected for quality assessment. The derivat...
Source: Journal of Pharmaceutical Analysis - January 16, 2020 Category: Drugs & Pharmacology Source Type: research
Polysaccharide-based chromatographic adsorbents for virus purification and viral clearance
Publication date: Available online 13 January 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Guy-Alain Junter, Laurent LebrunAbstractViruses still represent a significant threat to human and animal health worldwide. In the fight against viral infections, high-purity viral stocks are needed for manufacture of safer vaccines. It is also a priority to ensure the viral safety of biopharmaceuticals such as blood products. Chromatography techniques are widely implemented at both academic and industrial levels in the purification of viral particles, whole viruses and virus-like particles, and to remove viral contaminant...
Source: Journal of Pharmaceutical Analysis - January 14, 2020 Category: Drugs & Pharmacology Source Type: research
The current status of anti GPCR drugs against different cancers
Publication date: Available online 11 January 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Sana Usman, Maria Khawer, Shazia Rafique, Zara Naz, Komal SaleemAbstractG protein coupled receptors (GPCRs) have been emerged as most potential target for a number of drug discovery programs ranging from control of blood pressure, diabetes, cure for genetic diseases to treatment of cancer. A panel of different ligands including hormones, peptides, ions and small molecules is responsible for activation of these receptors. Molecular genetics have identified key GPCRs, whose mutations or altered expression are linked with tu...
Source: Journal of Pharmaceutical Analysis - January 12, 2020 Category: Drugs & Pharmacology Source Type: research
