Development and validation of an HPLC-UV method for analysis of methylphenidate hydrochloride and loxapine succinate in an activated carbon disposal system
Publication date: Available online 16 December 2017Source: Journal of Pharmaceutical AnalysisAuthor(s): Pooja Bakshi, Andrew Korey, William Fowler, Ajay K. BangaAbstractUnused medications have the possibility of being abused, causing serious harm to individuals who were not prescribed the drug. The Food and Drug Administration (FDA) recommends the proper disposal of unused prescribed medications to maintain safety and prevent environmental hazards. However, many of the current disposal techniques do not properly address safety. A drug disposal pouch containing granular activated carbon offers a unique disposal method to de...
Source: Journal of Pharmaceutical Analysis - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Production and stability study of a hospital parenteral nutrition solution for neonates
The objective of this study was to investigate the physicochemical and microbiological stability of a hospital preparation for parenteral nutrition in neonatology. The analyses were performed throughout the storage of the preparations at 2–8 °C (up to 4 months). The extent of stability was based on the determination of amino acids dosage, visual and physicochemical properties (glucose and electrolytes concentrations, pH and osmolality measurements, particle counting) and microbiological analysis (sterility test). A thermal degradation of ascorbic acid was conducted to evaluate the antioxidant properties of the parente...
Source: Journal of Pharmaceutical Analysis - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Quantitation of tadalafil in human plasma using a sensitive and rapid LC-MS/MS method for a bioequivalence study
Publication date: Available online 31 January 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Abhaysingh Bhadoriya, Bhavesh Dasandi, Dharmesh Parmar, Priyanka A. Shah, Pranav S. ShrivastavAbstractA highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the determination of tadalafil (TAD) in human plasma. TAD and its deuterated internal standard (IS), tadalafil-d3, were extracted from 200 µL plasma using Phenomenex Strata-X-C 33 µ extraction cartridges. Chromatographic analysis was carried out on Synergi™ Hydro-RP C18 (100 mm × 4.6 mm, 4 µm) column with ...
Source: Journal of Pharmaceutical Analysis - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
LC and LC–MS/MS studies for the identification and characterization of degradation products of acebutolol
Publication date: Available online 15 March 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Uday Rakibe, Ravi Tiwari, Anand Mahajan, Vipul Rane, Pravin WakteAbstractThe aim of the present investigation was to demonstrate an approach involving use of liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC–MS) to separate, identify and characterize very small quantities of degradation products (DPs) of acebutolol without their isolation from the reaction mixtures. The drug was subjected to oxidative, hydrolytic, thermal and photolytic stress conditions as per International Conference on Harmoniz...
Source: Journal of Pharmaceutical Analysis - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Ultrasensitive electrochemical determination of metronidazole based on polydopamine/carboxylic multi-walled carbon nanotubes nanocomposites modified GCE
Publication date: April 2018Source: Journal of Pharmaceutical Analysis, Volume 8, Issue 2Author(s): Satar Tursynbolat, Yrysgul Bakytkarim, Jianzhi Huang, Lishi WangAbstractAn ultrasensitive electrochemical sensor based on polydopamine/carboxylic multi-walled carbon nanotubes (MWCNTs−COOH) nanocomposites modified glassy carbon electrode (GCE) was presented in this work, which has been developed for highly selective and highly sensitive determination of an antimicrobial drug, metronidazole. The preparation of polydopamine/MWCNTs–COOH nanocomposites/GCE sensor is simple and possesses high reproducible, where polydopamine ...
Source: Journal of Pharmaceutical Analysis - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
