Synthesis and electrochemical properties of environmental free l-glutathione grafted graphene oxide/ZnO nanocomposite for highly selective piroxicam sensing

Publication date: Available online 6 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): N. Dhanalakshmi, T. Priya, S. Thennarasu, S. Sivanesan, N. ThinakaranAbstractA simple and reliable strategy was proposed to engineer the glutathione grafted graphene oxide/ZnO nanocomposite (glutathione-GO/ZnO) as electrode material for the high-performance piroxicam sensor. The prepared glutathione-GO/ZnO nanocomposite was well characterized by X-ray Diffraction, Fourier Transform Infrared Spectrum, X-ray Photoelectron Spectroscopy, Field Emission Scanning Electron Microscopy, Cyclic Voltammetry, Electrochemical Impedance Spectroscopy and Differential Pulse Voltammetry. The novel nanocomposite modified electrode showed the highest electrocatalytic activity towards piroxicam (oxidation potential is 0.52 V). Under controlled experimental parameters, the proposed sensor exhibited good linear responses to piroxicam concentrations ranging from 0.1 to 500 μM. The detection limit and sensitivity was calculated as 1.8 nM and 0.2 μA/μM cm2, respectively. Moreover, it offers excellent selectivity, reproducibility, long-term stability and it can effectively ignore the interfering candidates commonly exist in the pharmaceutical tablets and human fluids even in the higher concentration. Finally, the reported sensor successfully employed to the direct determination of piroxicam in practical samples.Graphical abstractThe new approach of Facile and environmental free l-glutathio...
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research