Developing the Pathway to Personalized Health: The Potential of N-of-1 Studies for Personalizing Nutrition
Personalization is one of the dominant zeitgeists of the new millennium, driven by individuals who demand the right information or product or service at the right time for their needs and wants. The commercial world has taken note because the personalized nutrition market is expected to be worth $16.4 billion by 2025 (1), a business opportunity that includes direct-to-consumer genetic testing, digital health care, supplements, and foods for specialized physiological needs (e.g., pregnancy, athletics, health conditions). (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 22, 2021 Category: Nutrition Source Type: research
A Low-Sodium DASH Dietary Pattern Affects Serum Markers of Inflammation and Mineral Metabolism in Adults with Elevated Blood Pressure
ConclusionsContrary to our hypothesis, biomarkers of inflammation and mineral metabolism were increased or unchanged by a low-sodium DASH diet compared with a high-sodium control diet in adults with elevated blood pressure. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 22, 2021 Category: Nutrition Source Type: research
Reproducibility and Validity of Capillary Dried Blood Spot for Diagnosis of Vitamin A Deficiency and Anemia in Children & lt;5 Years Old
ConclusionsThe results suggest that DBS is adequate for the diagnosis of VAD in preschool children, but not for anemia. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 22, 2021 Category: Nutrition Source Type: research
Oils Rich in α-Linolenic Acid or Docosahexaenoic Acid Have Distinct Effects on Plasma Oxylipin and Adiponectin Concentrations and on Monocyte Bioenergetics in Women with Obesity
ConclusionsFlaxseed oil and fish oil each had unique effects on metabolic parameters in women with obesity. The supplementation regimens were insufficient to reduce inflammatory markers but adequate to elicit increases in omega-3 oxylipins and adiponectin in response to fish oil and to alter monocyte bioenergetics in response to flaxseed oil. This trial was registered at clinicaltrials.gov as NCT03583281. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 22, 2021 Category: Nutrition Source Type: research
Accurate Measurement of Nutrients and Nonnutritive Dietary Ingredients from Dietary Supplements Is Critical in the Precision Nutrition Era
See corresponding article onpage 2486. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 22, 2021 Category: Nutrition Source Type: research
Pinto Bean Amino Acid Digestibility and Score in a Mexican Dish with Corn Tortilla and Guacamole, Evaluated in Adults Using a Dual-Tracer Isotopic Method
ConclusionsA Mexican dish of pinto beans, tortillas, and guacamole is a good source of protein as evaluated in adults and could be promoted as a nutritious snack. The assay is registered with the Ethical Committee of the Centro de Investigaci ón en Alimentación y Desarrollo, A.C. as CE/015/2019. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 13, 2021 Category: Nutrition Source Type: research
Dose –Response Oxidation of Ingested Phytoglycogen during Exercise in Endurance-Trained Men
ConclusionsIn male endurance athletes, PHY oxidation plateaued at 0.72 –0.76 g·min−1 during 150 min of cycling at 50% Wmax (peak oxidation of 0.84 g·min−1 occurred during the final 30 min). This trial was registered at clinicaltrials.gov as NCT02909881. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 13, 2021 Category: Nutrition Source Type: research
Iodine Nutrition and Iodine Supplement Initiation in Association with Thyroid Function in Mildly-to-Moderately Iodine-Deficient Pregnant and Postpartum Women
ConclusionsLower iodine availability during pregnancy and postpartum was associated with lower TSH, and higher fT3 and fT4 concentrations. The use of an iodine-containing supplement that was initiated prepregnancy and continuing through pregnancy was associated with lower TSH, and higher fT3 and fT4 concentrations, which may suggest improved thyroid function. These findings support the notion that optimization of iodine intake should start before pregnancy.This trial was registered at clinicaltrials.gov as NCT02610959. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 13, 2021 Category: Nutrition Source Type: research
Vitamin D Supplementation and Sunlight Exposure on Serum Vitamin D Concentrations in 2 Parallel, Double-Blind, Randomized, Placebo-Controlled Trials
ConclusionsModerate supplementation of 15 ug/d cholecalciferol, in accordance with current recommendations, supports an adequate vitamin D status in adult women, irrespective of latitude, and might concomitantly prevent an increase in parathyroid hormone. The Interaction Between Vitamin D Supplementation and Sunlight Exposure in Women Living in Opposite Latitudes (D-SOL) study was registered at clinicaltrials.gov as NCT03318029. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 13, 2021 Category: Nutrition Source Type: research
Fine-Tuning of Postprandial Responses via Feeding Frequency and Leucine Supplementation Affects Dietary Performance in Turbot (Scophthalmus maximus L.)
ConclusionsWe provided comprehensive characterization of the postprandial kinetics of nutrient sensing and metabolic responses under different feeding regimens and leucine supplementation in turbot. Fine-tuning of postprandial kinetics could provide a new direction for better dietary utilization and animal performances in aquaculture. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 13, 2021 Category: Nutrition Source Type: research
Medium-Chain Triglyceride Oil and Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Trials
ConclusionsMCT oil does not affect total cholesterol, LDL cholesterol, or HDL cholesterol levels, but does cause a small increase in triglycerides. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 13, 2021 Category: Nutrition Source Type: research
Advantages of Studying the Metabolome in Response to Mixed-Macronutrient Challenges and Suggestions for Future Research Designs
ABSTRACTEvaluating the postprandial response to a dietary challenge containing all macronutrients —carbohydrates, lipids, and protein—may provide stronger insights of metabolic health than a fasted measurement. Metabolomic profiling deepens the understanding of the homeostatic and adaptive response to a dietary challenge by classifying multiple metabolic pathways and biomarkers. A total of 2 6 articles were identified that measure the human blood metabolome or lipidome response to a mixed-macronutrient challenge. Most studies were cross-sectional, exploring the baseline and postprandial response to the dietary challeng...
Source: Journal of Nutrition - July 13, 2021 Category: Nutrition Source Type: research
Individual Postprandial Glycemic Responses to Diet in n-of-1 Trials: Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR)
ConclusionsN-of-1 trials are feasible to characterize personal response to dietary intervention in young Chinese adults. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 13, 2021 Category: Nutrition Source Type: research
Suppression
of Energy Intake by Intragastric l-Tryptophan in Lean and Obese Men: Relations with Appetite Perceptions and Circulating Cholecystokinin and Tryptophan
ConclusionsIntragastric Trp has potent energy intake –suppressant effects, in both lean men and those with obesity, apparently related to the Trp:LNAAs ratio. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 13, 2021 Category: Nutrition Source Type: research
Whole- and Refined-Grain Consumption and Longitudinal Changes in Cardiometabolic Risk Factors in the Framingham Offspring Cohort
ConclusionsAmong middle- to older-age adults, replacing RG with WG may be an effective dietary modification to attenuate abdominal adiposity, dyslipidemia, and hyperglycemia over time, thereby reducing the risk of cardiometabolic diseases. (Source: Journal of Nutrition)
Source: Journal of Nutrition - July 13, 2021 Category: Nutrition Source Type: research
