The Inclusion of Folic Acid in Weekly Iron –Folic Acid Supplements Confers no Additional Benefit on Anemia Reduction in Nonpregnant Women: A Randomized Controlled Trial in Malaysia
ConclusionsDespite the low folate status among these nonpregnant Malaysian women, the inclusion of folic acid in weekly IFA supplements did not reduce anemia or improve iron status, over iron alone. However, the benefits of folic acid for neural tube defect prevention still warrant its retention in weekly IFA supplements.This trial was registered atwww.anzctr.org.au as ACTRN12619000818134. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

CUN-BAE Index as a Screening Tool to Identify Increased Metabolic Risk in Apparently Healthy Normal-Weight Adults and Those with Obesity
ConclusionsData obtained in our cohort of young normoglycemic volunteers support the use of the CUN-BAE index as a tool to estimate accurately body fat mass, but also as a first easy/effective screening tool to identify lean people with increased fat mass and increased metabolic risk.This trial was registered atclinicaltrials.gov as NCT04402697. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
ConclusionsDietary supplementation of citicoline for 12  wk improved overall memory performance, especially episodic memory, in healthy older males and females with AAMI. The findings suggest that regular consumption of citicoline may be safe and potentially beneficial against memory loss due to aging. This trial was registered atclinicaltrials.gov as NCT03369925. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Diet Quality and Lower Refined Grain Consumption are Associated With Less Weight Gain in a Multi-Ethnic Asian Adult Population
ConclusionsAmong Asian adults, increasing dietary quality, reducing soft drink consumption, and replacing white rice with whole grains, vegetables, and selected high-protein foods was associated with less weight gain. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Baseline Hemoglobin, Hepcidin, Ferritin, and Total Body Iron Stores are Equally Strong Diagnostic Predictors of a Hemoglobin Response to 12 Weeks of Daily Iron Supplementation in Cambodian Women
ConclusionsBaseline Hb as measured with a hematology analyzer was as strong a predictor of Hb response to iron supplementation as inflammation-adjusted ferritin, hepcidin, and inflammation-adjusted TBIS. This is positive given that the WHO currently uses the population-level anemia prevalence to guide recommendations for untargeted iron supplementation. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children
ConclusionsOf the 86 biomarkers, the strongest effect of fatty fish intake was on n –3 PUFAs, UIC, hair mercury, and plasma 1-MH. We observed no or limited effects on biomarkers related to micronutrient status, inflammation, or essential amino acid, choline oxidation, and tryptophan pathways.The trial was registered at clinicaltrials.gov (NCT02331667). (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Dietary n –3 PUFA Deficiency Increases Vulnerability to Scopolamine-Induced Cognitive Impairment in Male C57BL/6 Mice
ConclusionsDietary n –3 PUFA deficiency significantly decreases brain DHA concentrations and increases vulnerability to scopolamine-induced cognitive impairment in C57BL/6 male mice. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Evidence for Beneficial Associations between Isoenergetic Macronutrient Exchanges and Serum non-HDL Cholesterol, a Measure of All Circulating Atherogenic, apoB-Containing Lipoproteins
See corresponding article onpage 2317. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Maternal Overweight and Obesity during Pregnancy Are Associated with Neonatal, but Not Maternal, Hepcidin Concentrations
ConclusionsIn both pregnant women and neonates, hepcidin was responsive to iron status. Maternal prepregnancy overweight status, with or without including obese women, was associated with lower cord blood hepcidin, likely driven by lower iron status among the neonates of these mothers. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Bigu-Style Fasting Affects Metabolic Health by Modulating Taurine, Glucose, and Cholesterol Homeostasis in Healthy Young Adults
ConclusionsOur data demonstrate that 5-d Bigu is potentially beneficial to health in young adults. A starvation threshold of 3-d fasting is necessary for maintaining glucose and cholesterol homeostasis via a taurine –microbiota regulatory loop. Our findings provide novel insights into the physiological and metabolic responses of the human body to continuous Bigu-style fasting. This trial was registered athttp://www.chictr.org.cn as ChiCTR1900022917. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Patterns of Growth in Childhood in Relation to Adult Schooling Attainment and Intelligence Quotient in 6 Birth Cohorts in Low- and Middle-Income Countries: Evidence from the Consortium of Health-Oriented Research in Transitioning Societies (COHORTS)
ConclusionsLinear growth in the first 1000 d is a predictor of schooling attainment and IQ in adulthood in LMICs. Linear growth in later periods was not associated with either of these outcomes. Changes in relative weight across the life course were not associated with schooling and IQ in adulthood. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Low Circulating Vitamin D in Intensive Care Unit –Admitted COVID-19 Patients as a Predictor of Negative Outcomes
ConclusionsThe ICU patients had a low serum 25(OH)D concentration. Serum 25(OH)D concentrations ≤9.9 ng/mL on admission can be used to predict in-hospital mortality in patients with COVID-19.This trial was registered atclinicaltrials.gov as NCT04450017. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Lactoferrin Is a Potential Activator of the Vitamin D Receptor in Its Regulation of Osteogenic Activities in C57BL/6J Mice and MC3T3-E1 Cells
ConclusionsIn vivo and in vitro, LF, a potential activator of VDR, promotes osteogenesis. This suggests that dairy products, which are rich in LF, may serve as a functional food to improve bone health. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

High-Quality Supplemental Protein Enhances Acute Muscle Protein Synthesis and Long-Term Strength Adaptations to Resistance Training in Young and Old Adults
See corresponding article onpage 1901. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research

Advances in Vitamin A Assessment: From Mathematical Modeling to Field Application
See corresponding article onpage 2068. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 12, 2021 Category: Nutrition Source Type: research