JAHA:Journal of the American Heart Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction [Vascular Medicine]
ConclusionsRac1 pharmacological inhibition rescues endothelial function and reduces oxidative stress in dysfunctional veins. Rac1 inhibition may represent a potential therapeutic intervention to reduce human endothelial dysfunction and subsequently vascular diseases in various clinical settings. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 28, 2017 Category: Cardiology Authors: Carrizzo, A., Vecchione, C., Damato, A., di Nonno, F., Ambrosio, M., Pompeo, F., Cappello, E., Capocci, L., Peruzzi, M., Valenti, V., Biondi-Zoccai, G., Marullo, A. G. M., Palmerio, S., Carnevale, R., Spinelli, C. C., Puca, A. A., Rubattu, S., Volpe, M., Tags: Endothelium/Vascular Type/Nitric Oxide, Oxidant Stress Original Research Source Type: research

Improved Diastolic Function Is Associated With Higher Cardiac Output in Patients With Heart Failure Irrespective of Left Ventricular Ejection Fraction [Heart Failure]
ConclusionsDiastolic function normalization was associated with higher CO irrespective of EF. Diastolic dysfunction plays an important role in determining CO irrespective of EF in heart failure patients. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 28, 2017 Category: Cardiology Authors: Tobushi, T., Nakano, M., Hosokawa, K., Koga, H., Yamada, A. Tags: Hemodynamics, Heart Failure Original Research Source Type: research

Immunosuppression With Mycophenolate Mofetil Attenuates Hypertension in an Experimental Model of Autoimmune Disease [Hypertension]
ConclusionsThese data suggest that MMF selectively depleted CD45R+ B cells and lowered subsequent autoantibody production, furthering the concept that autoantibodies mechanistically contribute to the pathogenesis of hypertension. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 27, 2017 Category: Cardiology Authors: Taylor, E. B., Ryan, M. J. Tags: Inflammation, Hypertension Original Research Source Type: research

Ketone Body Infusion With 3-Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study [Molecular Cardiology]
BackgroundHigh levels of ketone bodies are associated with improved survival as observed with regular exercise, caloric restriction, and—most recently—treatment with sodium–glucose linked transporter 2 inhibitor antidiabetic drugs. In heart failure, indices of ketone body metabolism are upregulated, which may improve energy efficiency and increase blood flow in skeletal muscle and the kidneys. Nevertheless, it is uncertain how ketone bodies affect myocardial glucose uptake and blood flow in humans. Our study was therefore designed to test whether ketone body administration in humans reduces myocardial glucose uptake ...
Source: JAHA:Journal of the American Heart Association - February 27, 2017 Category: Cardiology Authors: Gormsen, L. C., Svart, M., Thomsen, H. H., Sondergaard, E., Vendelbo, M. H., Christensen, N., Tolbod, L. P., Harms, H. J., Nielsen, R., Wiggers, H., Jessen, N., Hansen, J., Botker, H. E., Moller, N. Tags: Basic Science Research, Myocardial Biology, Nuclear Cardiology and PET Original Research Source Type: research

Divergent Effects of miR-181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets [Molecular Cardiology]
ConclusionsThe miR‐181 family alters the myocardial response to oxidative stress, notably with detrimental effects by targeting mt‐COX1 (miR‐181c) or with protection by targeting PTEN (miR‐181a/b). (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 27, 2017 Category: Cardiology Authors: Das, S., Kohr, M., Dunkerly-Eyring, B., Lee, D. I., Bedȷa, D., Kent, O. A., Leung, A. K. L., Henao-Meȷia, J., Flavell, R. A., Steenbergen, C. Tags: Cell Signaling/Signal Transduction, Ischemia, Oxidant Stress, Genetically Altered and Transgenic Models, Myocardial Infarction Original Research Source Type: research

Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study [Coronary Heart Disease]
BackgroundPlaque rupture and erosion are the 2 most common mechanisms for acute coronary syndromes. However, the outcome of these 2 distinct pathologies in patients with acute coronary syndromes has never been studied.Methods and ResultsWe retrospectively studied 141 patients with acute coronary syndromes who underwent optical coherence tomography (OCT) imaging of the culprit lesion prior to stenting from the Massachusetts General Hospital OCT Registry. Management (stent versus no stent), poststent OCT findings, and outcomes were compared. Among the 141 culprit lesions, rupture was found in 79 (56%) patients and erosion in...
Source: JAHA:Journal of the American Heart Association - February 24, 2017 Category: Cardiology Authors: Hu, S., Zhu, Y., Zhang, Y., Dai, J., Li, L., Dauerman, H., Soeda, T., Wang, Z., Lee, H., Wang, C., Zhe, C., Wang, Y., Zheng, G., Zhang, S., Jia, H., Yu, B., Jang, I.-K. Tags: Optical Coherence Tomography (OCT), Treatment, Thrombosis Original Research Source Type: research

Effect of Race and Ethnicity on Antihypertensive Medication Utilization Among Women in the United States: Study of Women's Health Across the Nation (SWAN) [Health Services and Outcomes Research]
ConclusionsAmong this large cohort of multiethnic midlife women, use of antihypertensive medications increased over time, with angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers becoming the most commonly used antihypertensive medication, even for blacks. Thiazide diuretic utilization increased over time for all race/ethnic groups as did use of calcium channel blockers among blacks; both patterns are in line with guideline recommendations for the management of hypertension. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 23, 2017 Category: Cardiology Authors: Jackson, E. A., Ruppert, K., Derby, C. A., Lian, Y., Neal-Perry, G., Habel, L. A., Tepper, P. G., Harlow, S. D., Solomon, D. H. Tags: Epidemiology, Race and Ethnicity, Women, Hypertension, Health Services Original Research Source Type: research

Performance of Emergency Department Screening Criteria for an Early ECG to Identify ST-Segment Elevation Myocardial Infarction [Health Services and Outcomes Research]
ConclusionsThe 29.2% difference in MCRs between the highest and lowest performing EDs demonstrates room for improving timely STEMI identification among primarily screened ED patients. The MCR and informedness can be used to compare screening across EDs and to understand variable performance. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 23, 2017 Category: Cardiology Authors: Yiadom, M. Y. A. B., Baugh, C. W., McWade, C. M., Liu, X., Song, K. J., Patterson, B. W., Jenkins, C. A., Tanski, M., Mills, A. M., Salazar, G., Wang, T. J., Dittus, R. S., Liu, D., Storrow, A. B. Tags: Clinical Studies, Ischemia, Diagnostic Testing, Electrocardiology (ECG), Vascular Disease Original Research Source Type: research

Long-Term Administration of Eicosapentaenoic Acid Improves Post-Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization [Coronary Heart Disease]
ConclusionsLong‐term administration of EPA improved the prognosis of and attenuated chronic cardiac remodeling after MI by modulating the activation of proinflammatory M1 macrophages. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 21, 2017 Category: Cardiology Authors: Takamura, M., Kurokawa, K., Ootsuji, H., Inoue, O., Okada, H., Nomura, A., Kaneko, S., Usui, S. Tags: Fibrosis, Ischemia, Heart Failure, Myocardial Infarction, Remodeling Original Research Source Type: research

Heart Failure With Preserved Ejection Fraction: An Opportunity for Reflection [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: Gupta, D. K. Tags: Endothelium/Vascular Type/Nitric Oxide, Heart Failure Editorial Source Type: research

Alcohol Consumption Patterns and Vascular Properties: The Value of Repeatedly Measured Longitudinal Data [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: Zachariah, J. P. Tags: Hemodynamics, Aging, Lifestyle, Risk Factors, Hypertension Editorial Source Type: research

Clinical Conundrum of Coronary Artery Disease and Aortic Valve Stenosis [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: El Sabbagh, A., Nishimura, R. A. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation, Catheter-Based Coronary and Valvular Interventions Editorial Source Type: research

Twenty-Five-Year Alcohol Consumption Traȷectories and Their Association With Arterial Aging: A Prospective Cohort Study [Epidemiology]
ConclusionsThis work demonstrates that consistently heavy alcohol consumption is associated with higher cardiovascular risk, especially among males, and also provides new insights into the potential impact of changes in drinking levels over time. It discusses the additional insights possible when capturing longitudinal consumption patterns in lieu of reliance on recent intake alone.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02663791. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: O'Neill, D., Britton, A., Brunner, E. J., Bell, S. Tags: Cardiovascular Disease, Diet and Nutrition, Epidemiology, Lifestyle, Risk Factors Original Research Source Type: research

Time Trends and Educational Inequalities in Out-of-Hospital Coronary Deaths in Norway 1995-2009: A Cardiovascular Disease in Norway (CVDNOR) Proȷect [Coronary Heart Disease]
BackgroundRecent time trends and educational gradients characterizing out‐of‐hospital coronary deaths (OHCD) are poorly described.Methods and ResultsWe identified all deaths from coronary heart disease occurring outside the hospital in Norway during 1995 to 2009. Time trends were explored using Poisson regression analysis with year as the independent, continuous variable. Information on the highest achieved education was obtained from The National Education Database and classified as primary (up to 10 years of compulsory education), secondary (high school or vocational school), or tertiary (college/university). Educati...
Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: Sulo, E., Nygard, O., Vollset, S. E., Igland, J., Ebbing, M., Ostbye, T., Jorgensen, T., Sulo, G., Tell, G. S. Tags: Cardiovascular Disease Original Research Source Type: research

Predictive Value of Dobutamine Stress Perfusion Echocardiography in Contemporary End-Stage Liver Disease [Cardiovascular Nursing]
ConclusionsStress MVP assessments are highly predictive of cardiovascular outcome in current LT candidates. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: Baibhav, B., Mahabir, C. A., Xie, F., Shostrom, V. K., McCashland, T. M., Porter, T. R. Tags: Echocardiography, Transplantation, Coronary Artery Disease Original Research Source Type: research