Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction [Vascular Medicine]

ConclusionsRac1 pharmacological inhibition rescues endothelial function and reduces oxidative stress in dysfunctional veins. Rac1 inhibition may represent a potential therapeutic intervention to reduce human endothelial dysfunction and subsequently vascular diseases in various clinical settings.

Source: JAHA:Journal of the American Heart Association - February 28, 2017 Category: Cardiology Authors: Carrizzo, A., Vecchione, C., Damato, A., di Nonno, F., Ambrosio, M., Pompeo, F., Cappello, E., Capocci, L., Peruzzi, M., Valenti, V., Biondi-Zoccai, G., Marullo, A. G. M., Palmerio, S., Carnevale, R., Spinelli, C. C., Puca, A. A., Rubattu, S., Volpe, M., Tags: Endothelium/Vascular Type/Nitric Oxide, Oxidant Stress Original Research Source Type: research