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Bone Marrow-Derived MicroRNA-223 Works as an Endocrine Genetic Signal in Vascular Endothelial Cells and Participates in Vascular Inȷury From Kawasaki Disease [Vascular Medicine]
ConclusionsIn KD patients, the levels of blood cell–derived miR‐223 in ECs are significantly increased. The increased miR‐223 in ECs could work as a novel endocrine genetic signal and participate in vascular injury of KD. MiR‐223 may provide a novel mechanism and a new therapeutic target for vascular complication of KD. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Chu, M., Wu, R., Qin, S., Hua, W., Shan, Z., Rong, X., Zeng, J., Hong, L., Sun, Y., Liu, Y., Li, W., Wang, S., Zhang, C. Tags: Translational Studies, Vascular Biology, Vascular Disease Original Research Source Type: research

Maȷor Bleeding Complications and Persistence With Oral Anticoagulation in Non-Valvular Atrial Fibrillation: Contemporary Findings in Real-Life Danish Patients [Epidemiology]
ConclusionsIn a real‐world cohort of nonvalvular atrial fibrillation patients, apixaban had a lower adjusted major bleeding risk compared with rivaroxaban, dabigatran, and warfarin. Apixaban had a lower risk of nonpersistence compared with dabigatran and warfarin and similar risk compared with rivaroxaban. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Lamberts, M., Staerk, L., Olesen, J. B., Fosbol, E. L., Hansen, M. L., Harboe, L., Lefevre, C., Evans, D., Gislason, G. H. Tags: Atrial Fibrillation, Epidemiology, Anticoagulants, Complications Original Research Source Type: research

Racial-Ethnic Disparities in Acute Stroke Care in the Florida-Puerto Rico Collaboration to Reduce Stroke Disparities Study [Epidemiology]
We examined race‐ethnic disparities in acute stroke performance metrics in a voluntary stroke registry among Florida and Puerto Rico Get With the Guidelines‐Stroke hospitals.Methods and ResultsSeventy‐five sites in the Florida Puerto Rico Stroke Registry (66 Florida and 9 Puerto Rico) recorded 58 864 ischemic stroke cases (2010–2014). Logistic regression models examined racial‐ethnic differences in acute stroke performance measures and defect‐free care (intravenous tissue plasminogen activator treatment, in‐hospital antithrombotic therapy, deep vein thrombosis prophylaxis, discharge antithrombotic therapy, a...
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Sacco, R. L., Gardener, H., Wang, K., Dong, C., Ciliberti-Vargas, M. A., Gutierrez, C. M., Asdaghi, N., Burgin, W. S., Carrasquillo, O., Garcia-Rivera, E. J., Nobo, U., Oluwole, S., Rose, D. Z., Waters, M. F., Zevallos, J. C., Robichaux, M., Waddy, S. P., Tags: Epidemiology, Race and Ethnicity, Treatment, Cerebrovascular Disease/Stroke Original Research Source Type: research

Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons With Heightened Platelet Aggregation [Corrections]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Tags: Correction Source Type: research

Heart Failure, Left Ventricular Remodeling, and Circulating Nitric Oxide Metabolites [Corrections]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Tags: Correction Source Type: research

Initiation, Continuation, or Withdrawal of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers and Outcomes in Patients Hospitalized With Heart Failure With Reduced Eȷection Fraction [Heart Failure]
BackgroundGuidelines recommend continuation or initiation of guideline‐directed medical therapy, including angiotensin‐converting enzyme inhibitors/angiotensin II receptor blockers (ACEi/ARB), in hospitalized patients with heart failure with reduced ejection fraction.Methods and ResultsUsing the Get With The Guidelines‐Heart Failure Registry, we linked clinical data from 16 052 heart failure with reduced ejection fraction (ejection fraction ≤40%) patients with Medicare claims data. We divided ACEi/ARB‐eligible patients into 4 categories based on admission and discharge ACEi/ARB use: continued (reference group), ...
Source: JAHA:Journal of the American Heart Association - February 11, 2017 Category: Cardiology Authors: Gilstrap, L. G., Fonarow, G. C., Desai, A. S., Liang, L., Matsouaka, R., DeVore, A. D., Smith, E. E., Heidenreich, P., Hernandez, A. F., Yancy, C. W., Bhatt, D. L. Tags: Heart Failure, Mortality/Survival, Quality and Outcomes, Statements and Guidelines Original Research Source Type: research

Frailty, Physical Activity, and Mobility in Patients With Cardiac Implantable Electrical Devices [Arrhythmia and Electrophysiology]
This study aimed to demonstrate the feasibility of measuring frailty in patients with cardiac implantable electrical devices while validating the physiologic significance of device‐detected physical activity by evaluating its association with frailty and mobility.Methods and ResultsOutpatients with cardiac implantable electrical devices compatible with physical activity analysis with at least 7 days of data were eligible. Office testing included frailty status (Study of Osteoporotic Fractures instrument), gait speed (m/s), mobility according to the Timed Up and Go (TUG) test (seconds), and daily physical activity (h/d) ...
Source: JAHA:Journal of the American Heart Association - February 10, 2017 Category: Cardiology Authors: Kramer, D. B., Tsai, T., Natarajan, P., Tewksbury, E., Mitchell, S. L., Travison, T. G. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Aging, Quality and Outcomes Original Research Source Type: research

Long-Term Risk of Cardiovascular Events in Patients With Chronic Kidney Disease Who Have Survived Sepsis: A Nationwide Cohort Study [Epidemiology]
ConclusionsOur findings highlight the association of sepsis with a significantly increased long‐term risk of cardiovascular events among survivors in the chronic kidney disease population. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 10, 2017 Category: Cardiology Authors: Shih, C.-J., Chao, P.-W., Ou, S.-M., Chen, Y.-T. Tags: Cardiovascular Disease, Epidemiology, Risk Factors Original Research Source Type: research

Population Impact & Efficiency of Benefit‐Targeted Versus Risk-Targeted Statin Prescribing for Primary Prevention of Cardiovascular Disease [Epidemiology]
ConclusionsBenefit‐based targeting of statin therapy provides modest gains in efficiency over risk‐based prescribing and could theoretically help attain approximately half of the Healthy People 2020 impact goal with reasonable efficiency. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 10, 2017 Category: Cardiology Authors: Pletcher, M. J., Pignone, M., Jarmul, J. A., Moran, A. E., Vittinghoff, E., Newman, T. Tags: Lipids and Cholesterol, Cardiovascular Disease, Epidemiology, Primary Prevention Original Research Source Type: research

MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts [Heart Failure]
ConclusionsWe have elucidated a novel miR‐30‐GALNT1/2 axis whose dysregulation increases the proportion of inactive proBNP secreted by the heart and impairs the compensatory actions of BNP during the progression of heart failure. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 10, 2017 Category: Cardiology Authors: Nakagawa, Y., Nishikimi, T., Kuwahara, K., Fujishima, A., Oka, S., Tsutamoto, T., Kinoshita, H., Nakao, K., Cho, K., Inazumi, H., Okamoto, H., Nishida, M., Kato, T., Fukushima, H., Yamashita, J. K., Wijnen, W. J., Creemers, E. E., Kangawa, K., Minamino, N Tags: Biomarkers, Cell Signaling/Signal Transduction, Translational Studies, Heart Failure Original Research Source Type: research

Endothelial Dysfunction in Children With Obstructive Sleep Apnea Is Associated With Elevated Lipoprotein-Associated Phospholipase A2 Plasma Activity Levels [Pediatric Cardiology]
BackgroundObstructive sleep apnea (OSA) is a highly prevalent condition, especially in obese children, and has been associated with increased risk for endothelial dysfunction and dislipidemia, which are precursors of atherosclerosis. Lipoprotein‐associated phospholipase A2 (Lp‐PLA2) is recognized as an independent risk factor for cardiovascular risk and atheromatous plaque activity. We hypothesized that Lp‐PLA2 levels would be elevated in children with OSA, particularly among obese children who also manifest evidence of endothelial dysfunction.Methods and ResultsOne hundred sixty children (mean age 7.1±2.3 years), ...
Source: JAHA:Journal of the American Heart Association - February 9, 2017 Category: Cardiology Authors: Kheirandish-Gozal, L., Philby, M. F., Qiao, Z., Khalyfa, A., Gozal, D. Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Lipids and Cholesterol, Pediatrics, Atherosclerosis Original Research Source Type: research

Modifiable Risk Factors Versus Age on Developing High Predicted Cardiovascular Disease Risk in Blacks [Epidemiology]
The objective was to compare the contribution of changes in modifiable risk factors versus aging to the development of high 10‐year predicted ASCVD risk.Methods and ResultsA prospective follow‐up was done of the Jackson Heart Study, an exclusively black cohort at visit 1 (2000–2004) and visit 3 (2009–2012). Analyses included 1115 black participants without high 10‐year predicted ASCVD risk ( (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 8, 2017 Category: Cardiology Authors: Bress, A. P., Colantonio, L. D., Booth, J. N., Spruill, T. M., Ravenell, J., Butler, M., Shallcross, A. J., Seals, S. R., Reynolds, K., Ogedegbe, G., Shimbo, D., Muntner, P. Tags: Cardiovascular Disease, Race and Ethnicity, Risk Factors, High Blood Pressure, Hypertension Original Research Source Type: research

Indoxyl Sulfate: A Novel Cardiovascular Risk Factor in Chronic Kidney Disease [Contemporary Review]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 7, 2017 Category: Cardiology Authors: Hung, S.-C., Kuo, K.-L., Wu, C.-C., Tarng, D.-C. Tags: Biomarkers, Mechanisms, Nephrology and Kidney, Pathophysiology, Vascular Biology Contemporary Review Source Type: research

Does Additional Electrogram-Guided Ablation After Linear Ablation Reduce Recurrence After Catheter Ablation for Longstanding Persistent Atrial Fibrillation? A Prospective Randomized Study [Arrhythmia and Electrophysiology]
This study enrolled 137 L‐PeAF patients (71.4% male, 61.6±10.9 years old) who underwent radiofrequency catheter ablation. We conducted CPVI+Line based on the Dallas lesion set (posterior box+anterior line) after baseline CFAE mapping in all patients. If AF was defragmented (terminated or changed to atrial tachycardia), the procedure was stopped (AF‐Defrag group, n=29). If AF was maintained after CPVI+Line, we mapped the CFAE again and randomly assigned the patient to the CPVI+Line group (n=54) or the additional CFAE ablation group (CPVI+Line+CFAE group, n=54). L‐PeAF was defragmented during CPVI+Line in 21.2% of pa...
Source: JAHA:Journal of the American Heart Association - February 7, 2017 Category: Cardiology Authors: Kim, T.-H., Uhm, J.-S., Kim, J.-Y., Joung, B., Lee, M.-H., Pak, H.-N. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator Original Research Source Type: research

Altered Blood Flow Response to Small Muscle Mass Exercise in Cancer Survivors Treated With Adjuvant Therapy [Exercise Physiology]
ConclusionsThese data suggest an attenuated exercise blood flow response in cancer survivors ≈34 months following adjuvant cancer therapy that may be attributed to an attenuated increase in mean arterial pressure. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 7, 2017 Category: Cardiology Authors: Didier, K. D., Ederer, A. K., Reiter, L. K., Brown, M., Hardy, R., Caldwell, J., Black, C., Bemben, M. G., Ade, C. J. Tags: Physiology, Exercise Original Research Source Type: research