Bone Marrow-Derived MicroRNA-223 Works as an Endocrine Genetic Signal in Vascular Endothelial Cells and Participates in Vascular Inȷury From Kawasaki Disease [Vascular Medicine]

ConclusionsIn KD patients, the levels of blood cell–derived miR‐223 in ECs are significantly increased. The increased miR‐223 in ECs could work as a novel endocrine genetic signal and participate in vascular injury of KD. MiR‐223 may provide a novel mechanism and a new therapeutic target for vascular complication of KD.

Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Chu, M., Wu, R., Qin, S., Hua, W., Shan, Z., Rong, X., Zeng, J., Hong, L., Sun, Y., Liu, Y., Li, W., Wang, S., Zhang, C. Tags: Translational Studies, Vascular Biology, Vascular Disease Original Research Source Type: research