JAHA:Journal of the American Heart Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Relationship Between Peak Troponin Values and Long-Term Ischemic Events Among Medically Managed Patients With Acute Coronary Syndromes [Coronary Heart Disease]
BackgroundThe relationship between troponin level and outcomes among patients with non‐ST‐segment elevation ACS is established, but the relationship of troponin level with long‐term outcomes among medically managed non‐ST‐segment elevation ACS patients receiving contemporary antiplatelet therapy is inadequately defined.Methods and ResultsIn 6763 medically managed non‐ST‐segment elevation ACS patients randomized in TRILOGY ACS (Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes) (prasugrel versus clopidogrel), we examined relationships between categories o...
Source: JAHA:Journal of the American Heart Association - April 11, 2017 Category: Cardiology Authors: Goldstein, S. A., Newby, L. K., Cyr, D. D., Neely, M., Luscher, T. F., Brown, E. B., White, H. D., Ohman, E. M., Roe, M. T., Hamm, C. W. Tags: Acute Coronary Syndromes Original Research Source Type: research

Health Literacy and Awareness of Atrial Fibrillation [Arrhythmia and Electrophysiology]
ConclusionsLower health literacy is independently associated with less awareness of AF diagnosis. Strategies designed to increase patient awareness of AF and its complications are warranted among individuals with limited health literacy. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 11, 2017 Category: Cardiology Authors: Reading, S. R., Go, A. S., Fang, M. C., Singer, D. E., Liu, I.–L. A., Black, M. H., Udaltsova, N., Reynolds, K., the Anticoagulation and Risk Factors in Atrial Fibrillation-Cardiovascular Research Network (ATRIA-CVRN) Investigators Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Health Services Original Research Source Type: research

Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic Syndrome [Heart Failure]
ConclusionsAlthough the small arteries studied were not cardiac in origin, our results support a role for small artery remodeling in the development of diastolic dysfunction in humans. Further direct examination of the structure and function of the myocardial resistance vasculature is now warranted, to elucidate the temporal association between metabolic risk factors, small artery injury, and diastolic impairment. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 11, 2017 Category: Cardiology Authors: Khavandi, K., Aghamohammadzadeh, R., Luckie, M., Brownrigg, J., Alam, U., Khattar, R., Malik, R. A., Heagerty, A. M., Greenstein, A. S. Tags: Endothelium/Vascular Type/Nitric Oxide, Vascular Biology, Heart Failure, Metabolic Syndrome, Hypertension Original Research Source Type: research

Optimal Timing of Complete Revascularization in Acute Coronary Syndrome: A Systematic Review and Meta–Analysis [Systematic Review and Meta-Analysis]
ConclusionsOur results suggest that single‐stage complete revascularization is safe. There also appears to be a trend towards lower long‐term risks of mortality and major adverse cardiovascular events; however, additional randomized controlled trials are required to confirm the potential benefits of single‐stage multivessel percutaneous coronary intervention. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 10, 2017 Category: Cardiology Authors: Gaffar, R., Habib, B., Filion, K. B., Reynier, P., Eisenberg, M. J. Tags: Percutaneous Coronary Intervention, Revascularization, Meta Analysis, Acute Coronary Syndromes, Coronary Artery Disease Systematic Review and Meta ‐ Source Type: research

Local Ancestry and Clinical Cardiovascular Events Among African Americans From the Atherosclerosis Risk in Communities Study [Genetics]
ConclusionsFuture studies are needed to replicate and/or determine the causal variants driving our associations and explore clinical applications for those consistently associated with CVEs. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 10, 2017 Category: Cardiology Authors: Shendre, A., Irvin, M. R., Wiener, H., Zhi, D., Limdi, N. A., Overton, E. T., Shrestha, S. Tags: Cardiovascular Disease, Epidemiology, Race and Ethnicity, Risk Factors, Heart Failure Original Research Source Type: research

Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy [Arrhythmia and Electrophysiology]
ConclusionsTollip deficiency selectively leads to enlarged yet stable atherosclerotic plaques, increased circulating lipids, liver steatosis, and reduced inflammation. Compromised lipophagy and reduced expression of inflammatory mediators due to Tollip deficiency may be the underlying causes. Our data suggest that lipid accumulation and inflammation may be intertwined yet independent processes during the progression of atherosclerosis and steatosis. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 10, 2017 Category: Cardiology Authors: Chen, K., Yuan, R., Zhang, Y., Geng, S., Li, L. Tags: Inflammation, Mechanisms Original Research Source Type: research

Blood Pressure and Arterial Stiffness in Kenyan Adolescents With {alpha}+Thalassemia [Epidemiology]
ConclusionsThese data suggest that the presence of α+thalassemia does not affect BP and/or arterial stiffness in Kenyan adolescents. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 5, 2017 Category: Cardiology Authors: Etyang, A. O., Khayeka-Wandabwa, C., Kapesa, S., Muthumbi, E., Odipo, E., Wamukoya, M., Ngomi, N., Haregu, T., Kyobutungi, C., Tendwa, M., Makale, J., Macharia, A., Cruickshank, J. K., Smeeth, L., Scott, J. A. G., Williams, T. N. Tags: Endothelium/Vascular Type/Nitric Oxide, Vascular Biology, Genetics, High Blood Pressure Original Research Source Type: research

Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice [Stroke]
ConclusionsWe conclude that brain ischemia induces the formation of β‐hydroxybutyrate (ketogenesis) in the liver and the consumption of β‐hydroxybutyrate in the brain. This effect seems to be mediated by β‐adrenergic receptors. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 5, 2017 Category: Cardiology Authors: Koch, K., Berressem, D., Konietzka, J., Thinnes, A., Eckert, G. P., Klein, J. Tags: Ischemia, Metabolism, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Research Source Type: research

Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion [Molecular Cardiology]
ConclusionsFibroblast nuclei possess AT1R and AT2R binding sites that are coupled to intranuclear Ca2+‐mobilization and NO liberation, respectively. Intracellular Ang‐II signaling regulates fibroblast proliferation, collagen gene expression, and collagen secretion. Heart failure upregulates Ang‐II intracrine signaling‐components in atrial fibroblasts. These results show for the first time that nuclear angiotensin‐II receptor activation and intracrine Ang‐II signaling control fibroblast function and may have pathophysiological significance. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 5, 2017 Category: Cardiology Authors: Tadevosyan, A., Xiao, J., Surinkaew, S., Naud, P., Merlen, C., Harada, M., Qi, X., Chatenet, D., Fournier, A., Allen, B. G., Nattel, S. Tags: Arrhythmias, Cell Signaling/Signal Transduction, Fibrosis Original Research Source Type: research

Associations of Blood Pressure Dipping Patterns With Left Ventricular Mass and Left Ventricular Hypertrophy in Blacks: The Jackson Heart Study [Hypertension]
We examined the associations of BP dipping patterns (dipping, nondipping, and reverse dipping) with cardiovascular target organ damage (left ventricular mass index and left ventricular hypertrophy), among participants from the Jackson Heart Study, an exclusively black population–based cohort.Methods and ResultsAnalyses included 1015 participants who completed ambulatory BP monitoring and had echocardiography data from the baseline visit. Participants were categorized based on the nighttime to daytime systolic BP ratio into 3 patterns: dipping pattern (≤0.90), nondipping pattern (>0.90 to ≤1.00), and reverse dipping p...
Source: JAHA:Journal of the American Heart Association - April 5, 2017 Category: Cardiology Authors: Abdalla, M., Caughey, M. C., Tanner, R. M., Booth, J. N., Diaz, K. M., Anstey, D. E., Sims, M., Ravenell, J., Muntner, P., Viera, A. J., Shimbo, D. Tags: Epidemiology, Race and Ethnicity, Hypertension Original Research Source Type: research

Phase I Clinical Trial of Autologous Stem Cell-Sheet Transplantation Therapy for Treating Cardiomyopathy [Cardiovascular Surgery]
BackgroundWhen transplanted into failing heart, autologous somatic tissue–derived cells yield functional recovery via paracrine effects that enhance native regeneration. However, the therapeutic effects are modest. We developed a method in which scaffold‐free cell sheets are attached to the epicardial surface to maximize paracrine effects. This Phase I clinical trial tested whether transplanting autologous cell–sheets derived from skeletal muscle is feasible, safe, and effective for treating severe congestive heart failure.Methods and ResultsFifteen ischemic cardiomyopathy patients and 12 patients with dilated cardio...
Source: JAHA:Journal of the American Heart Association - April 5, 2017 Category: Cardiology Authors: Miyagawa, S., Domae, K., Yoshikawa, Y., Fukushima, S., Nakamura, T., Saito, A., Sakata, Y., Hamada, S., Toda, K., Pak, K., Takeuchi, M., Sawa, Y. Tags: Cardiomyopathy, Cardiovascular Surgery Original Research Source Type: research

Circulating microRNAs: Potential Markers of Cardiotoxicity in Children and Young Adults Treated With Anthracycline Chemotherapy [Heart Failure]
ConclusionsIn this pilot study, cardiac‐related plasma miRNAs are dysregulated following ACs. Plasma miR‐29b and ‐499 are acutely elevated post‐AC, with dose response relationships observed with anthracycline dose and markers of cardiac injury. Further evaluation of miRNAs may provide mechanistic insight into AC‐induced cardiotoxicity and yield biomarkers to facilitate earlier intervention to mitigate cardiotoxicity. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 4, 2017 Category: Cardiology Authors: Leger, K. J., Leonard, D., Nielson, D., de Lemos, J. A., Mammen, P. P. A., Winick, N. J. Tags: Biomarkers, Pediatrics, Cardiomyopathy, Complications Original Research Source Type: research

Myocardial Damage Detected by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Uncommon in Peripartum Cardiomyopathy [Heart Failure]
ConclusionsFactors other than focal myocardial damage detectable by LGE explain the initial transient depressions in baseline left ventricular ejection fraction, yet focal myocardial damage may contribute to persistent myocardial dysfunction and hinder recovery in a small minority. Most women exhibit favorable changes in ventricular function over 6 months.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01085955. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 3, 2017 Category: Cardiology Authors: Schelbert, E. B., Elkayam, U., Cooper, L. T., Givertz, M. M., Alexis, J. D., Briller, J., Felker, G. M., Chaparro, S., Kealey, A., Pisarcik, J., Fett, J. D., McNamara, D. M., the Investigations of Pregnancy Associated Cardiomyopathy (IPAC) Investigators Tags: Cardiomyopathy, Heart Failure Original Research Source Type: research

Cardioprotective Effects of Intracoronary Morphine in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention: A Prospective, Randomized Trial [Coronary Heart Disease]
ConclusionsIntracoronary morphine administration could not reduce myocardial infarct size in ST‐elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01738100. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 3, 2017 Category: Cardiology Authors: Gwag, H. B., Kim, E. K., Park, T. K., Lee, J. M., Yang, J. H., Song, Y. B., Choi, J.-H., Choi, S.-H., Lee, S. H., Chang, S.-A., Park, S.-J., Lee, S.-C., Park, S. W., Jang, W. J., Lee, M., Chun, W. J., Oh, J. H., Park, Y. H., Choe, Y. H., Gwon, H.-C., Hahn Tags: Magnetic Resonance Imaging (MRI), Pharmacology, Acute Coronary Syndromes Original Research Source Type: research

An East Asian Common Variant Vinculin P.Asp841His Was Associated With Sudden Unexplained Nocturnal Death Syndrome in the Chinese Han Population [Arrhythmia and Electrophysiology]
ConclusionsA VCL common variant was genetically and biophysically associated with Chinese SUNDS. The aggravation of loss of function of SCN5A caused by VCL‐D841H under acidosis supports that nocturnal sleep respiratory disorders with acidosis may play a key role in the pathogenesis of SUNDS. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 3, 2017 Category: Cardiology Authors: Cheng, J., Kyle, J. W., Lang, D., Wiedmeyer, B., Guo, J., Yin, K., Huang, L., Vaidyanathan, R., Su, T., Makielski, J. C. Tags: Sudden Cardiac Death Original Research Source Type: research