JAHA:Journal of the American Heart Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Performance of the Atherosclerotic Cardiovascular Disease Pooled Cohort Risk Equations by Social Deprivation Status [Epidemiology]
BackgroundThe atherosclerosis cardiovascular disease (ASCVD) Pooled Cohort risk equations have shown different calibration across US populations with varied levels of social deprivation.Methods and ResultsWe analyzed the calibration and discrimination of the Pooled Cohort risk equations by social deprivation status among 9066 REGARDS (REasons for Geographic And Racial Differences in Stroke) study participants not taking statins for whom ASCVD risk may lead to statin initiation. Patients were aged 45 to 79 years, had no ASCVD or diabetes mellitus, and had a low‐density lipoprotein cholesterol level 70 to 189 mg/dL. Soci...
Source: JAHA:Journal of the American Heart Association - March 17, 2017 Category: Cardiology Authors: Colantonio, L. D., Richman, J. S., Carson, A. P., Lloyd-Jones, D. M., Howard, G., Deng, L., Howard, V. J., Safford, M. M., Muntner, P., Goff, D. C. Tags: Cardiovascular Disease, Epidemiology, Lifestyle, Primary Prevention, Risk Factors Original Research Source Type: research

Coronary Atherosclerotic Vulnerable Plaque: Current Perspectives [Contemporary Review]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 17, 2017 Category: Cardiology Authors: Stefanadis, C., Antoniou, C.-K., Tsiachris, D., Pietri, P. Tags: Percutaneous Coronary Intervention, Treatment, Atherosclerosis, Coronary Artery Disease Contemporary Review Source Type: research

Insulin-Like Growth Factor Binding Protein 4 Fragments Provide Incremental Prognostic Information on Cardiovascular Events in Patients With ST-Segment Elevation Myocardial Infarction [Molecular Cardiology]
This study investigated the prognostic value of IGFBP‐4 fragments in patients with ST‐segment elevation myocardial infarction.Methods and ResultsWe prospectively included 656 patients with ST‐segment elevation myocardial infarction treated with percutaneous coronary intervention from September 2006 to December 2008. Blood samples were drawn before percutaneous coronary intervention, and levels of intact IGFBP‐4 and N‐terminal and C‐terminal IGFBP‐4 fragments were measured by specific assays. End points were 5‐year all‐cause and cardiovascular mortality and the combined end point of major adverse cardiac e...
Source: JAHA:Journal of the American Heart Association - March 17, 2017 Category: Cardiology Authors: Hjortebjerg, R., Lindberg, S., Pedersen, S., Mogelvang, R., Jensen, J. S., Oxvig, C., Frystyk, J., Bjerre, M. Tags: Myocardial Infarction, Atherosclerosis Original Research Source Type: research

Characterization of Foci and Breakthrough Sites During Persistent and Long-Standing Persistent Atrial Fibrillation in Patients: Studies Using High-Density (510-512 Electrodes) Biatrial Epicardial Mapping [Arrhythmia and Electrophysiology]
ConclusionsDuring persistent and long‐standing persistent atrial fibrillation, sustained foci manifested variable CLs. Spontaneous pauses or activation from other wave fronts explained the intermittency of foci and nonrandom breakthrough. Focal and nonrandom breakthrough activation occasionally produced wannabe reentry. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 17, 2017 Category: Cardiology Authors: Lee, S., Sahadevan, J., Khrestian, C. M., Markowitz, A., Waldo, A. L. Tags: Arrhythmias Original Research Source Type: research

Effect of 2013 ACC/AHA Blood Cholesterol Guidelines on Statin Treatment Patterns and Low-Density Lipoprotein Cholesterol in Atherosclerotic Cardiovascular Disease Patients [Health Services and Outcomes Research]
We examined statin use and LDL‐C levels before and after the 2013 ACC/AHA guidelines in patients with clinical ASCVD as defined in the guidelines.Methods and ResultsWe conducted a retrospective cohort study of adult commercial and Medicare Advantage health plan enrollees in the Optum Research Database. Patients had ≥1 claim with a diagnosis of clinical ASCVD between November 1, 2012 and December 31, 2014 and were continuously enrolled 6 months before (baseline) and 7 months after (follow‐up) the first ASCVD visit. Patients were assigned to monthly cohorts based on ASCVD event month. Statin use and intensity were me...
Source: JAHA:Journal of the American Heart Association - March 17, 2017 Category: Cardiology Authors: Okerson, T., Patel, J., DiMario, S., Burton, T., Seare, J., Harrison, D. J. Tags: Lipids and Cholesterol, Cardiovascular Disease Original Research Source Type: research

Prehypertensive Blood Pressures and Regional Cerebral Blood Flow Independently Relate to Cognitive Performance in Midlife [Hypertension]
ConclusionsRelationships at midlife between prehypertensive levels of systolic BP and both cognitive and brain function were modest but suggested the possible value of midlife intervention. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 17, 2017 Category: Cardiology Authors: Jennings, J. R., Muldoon, M. F., Ryan, C., Gach, H. M., Heim, A., Sheu, L. K., Gianaros, P. J. Tags: Autonomic Nervous System, Blood Pressure, Magnetic Resonance Imaging (MRI), Cognitive Impairment Original Research Source Type: research

Prognostic Impact of In-Hospital and Postdischarge Heart Failure in Patients With Acute Myocardial Infarction: A Nationwide Analysis Using Data From the Cardiovascular Disease in Norway (CVDNOR) Proȷect [Epidemiology]
BackgroundHeart failure (HF) is a serious complication of acute myocardial infarction (AMI). We explored the excess mortality associated with HF as an early or late complication of AMI and describe changes over time in such excess mortality.Methods and ResultsAll patients hospitalized with an incident AMI and without history of prior HF hospitalization were followed up to 1 year after AMI discharge for episodes of HF. New HF episodes were classified as in‐hospital HF if diagnosed during the AMI hospitalization or postdischarge HF if diagnosed within 1 year after discharge from the incident AMI. Logistic and Cox regress...
Source: JAHA:Journal of the American Heart Association - March 15, 2017 Category: Cardiology Authors: Sulo, G., Igland, J., Nygard, O., Vollset, S. E., Ebbing, M., Poulter, N., Egeland, G. M., Cerqueira, C., Jorgensen, T., Tell, G. S. Tags: Cardiovascular Disease, Epidemiology, Heart Failure Original Research Source Type: research

What Is the Evidence That the Tissue Doppler Index E/e' Reflects Left Ventricular Filling Pressure Changes After Exercise or Pharmacological Intervention for Evaluating Diastolic Function? A Systematic Review [Systematic Review and Meta-Analysis]
ConclusionsWe find that there is insufficient evidence that E/e′ can reliably assess LVFP changes in response to exercise or other interventions. We suggest that well‐designed prospective studies should be conducted for further evaluation. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 15, 2017 Category: Cardiology Authors: Sharifov, O. F., Gupta, H. Tags: Clinical Studies, Heart Failure, Diagnostic Testing, Echocardiography, Exercise Testing Systematic Review and Meta ‐ Analysis Source Type: research

Temporal Trends in Treatment and Outcomes of Acute Myocardial Infarction in Patients With Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Observational Study [Epidemiology]
ConclusionsIn Taiwan, a lower proportion of patients with COPD received evidence‐based therapies for acute myocardial infarction than did patients without COPD, and their clinical outcomes were inferior. Limited improvement in mortality was observed over the preceding 10 years and is attributable to the underuse of evidence‐based treatments. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 15, 2017 Category: Cardiology Authors: Su, T.-H., Chang, S.-H., Chen, P.-C., Chan, Y.-L. Tags: Cardiovascular Disease, Epidemiology, Myocardial Infarction, Treatment, Mortality/Survival Original Research Source Type: research

“Kids Save Lives”: Educating Schoolchildren in Cardiopulmonary Resuscitation Is a Civic Duty That Needs Support for Implementation [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 14, 2017 Category: Cardiology Authors: Bottiger, B. W., Semeraro, F., Wingen, S. Tags: Cardiopulmonary Resuscitation and Emergency Cardiac Care, Cardiopulmonary Arrest, Cardiovascular Disease, Epidemiology Editorial Source Type: research

Robust Generation of Quiescent Porcine Valvular Interstitial Cell Cultures [Valvular Heart Disease]
ConclusionsThe approach using a fibroblast media formulation with culture on collagen coatings generates quiescent VICs that more accurately mimic a healthy VIC population and thus has the potential to transform the study of the mechanisms of VIC activation and dysfunction involved in the early stages of calcific aortic valve disease. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 14, 2017 Category: Cardiology Authors: Porras, A. M., van Engeland, N. C. A., Marchbanks, E., McCormack, A., Bouten, C. V. C., Yacoub, M. H., Latif, N., Masters, K. S. Tags: Basic Science Research, Valvular Heart Disease Original Research Source Type: research

Unwarranted Variation in the Quality of Care for Patients With Diseases of the Thoracic Aorta [Cardiovascular Surgery]
ConclusionsChanges in the organization of services that address unwarranted variation in the provision of care for patients with thoracic aortic disease in England may result in more‐equitable access to treatment and improved outcomes. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 14, 2017 Category: Cardiology Authors: Bottle, A., Mariscalco, G., Shaw, M. A., Benedetto, U., Saratzis, A., Mariani, S., Bashir, M., Aylin, P., Jenkins, D., Oo, A. Y., Murphy, G. J., the UK Aortic Forum Tags: Health Services, Mortality/Survival, Quality and Outcomes Original Research Source Type: research

Cardiopulmonary Resuscitation Training in Schools Following 8 Years of Mandating Legislation in Denmark: A Nationwide Survey [Resuscitation Science]
ConclusionsDespite mandating legislation, school CPR training has not been successfully implemented. Completed CPR training was associated with believing other schools were conducting training, awareness of mandating legislation, presence of a school CPR training coordinator, teachers teacher feeling competent to conduct training, and having easy access to training material. Facilitating these factors may increase rates of school CPR training. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 14, 2017 Category: Cardiology Authors: Malta Hansen, C., Zinckernagel, L., Ersboll, A. K., Tȷornhoȷ-Thomsen, T., Wissenberg, M., Lippert, F. K., Weeke, P., Gislason, G. H., Kober, L., Torp-Pedersen, C., Folke, F. Tags: Cardiopulmonary Resuscitation and Emergency Cardiac Care, Cardiopulmonary Arrest Original Research Source Type: research

Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Inȷury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening [Molecular Cardiology]
ConclusionsThis evidence clearly illustrates that microcirculatory ischemia/reperfusion injury can be attributed to Mff‐dependent mitochondrial fission via voltage‐dependent anion channel 1/hexokinase 2–mediated mitochondrial permeability transition pore opening and mitochondrial reactive oxygen species/cardiolipin involved cyt‐c release. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 13, 2017 Category: Cardiology Authors: Zhou, H., Hu, S., Jin, Q., Shi, C., Zhang, Y., Zhu, P., Ma, Q., Tian, F., Chen, Y. Tags: Coronary Circulation, Basic Science Research, Cell Biology/Structural Biology, Endothelium/Vascular Type/Nitric Oxide, Vascular Biology Original Research Source Type: research

Interleukin 6 Inhibition and Coronary Artery Disease in a High-Risk Population: A Prospective Community-Based Clinical Study [Vascular Medicine]
ConclusionsEndothelial function is improved by tocilizumab in a high‐risk population, even as it increases total cholesterol and low‐density lipoprotein levels. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 13, 2017 Category: Cardiology Authors: Bacchiega, B. C., Bacchiega, A. B., Usnayo, M. J. G., Bedirian, R., Singh, G., Pinheiro, G. d. R. C. Tags: Endothelium/Vascular Type/Nitric Oxide, Inflammation, Atherosclerosis, Coronary Artery Disease Original Research Source Type: research