Robust Generation of Quiescent Porcine Valvular Interstitial Cell Cultures [Valvular Heart Disease]

ConclusionsThe approach using a fibroblast media formulation with culture on collagen coatings generates quiescent VICs that more accurately mimic a healthy VIC population and thus has the potential to transform the study of the mechanisms of VIC activation and dysfunction involved in the early stages of calcific aortic valve disease.

Source: JAHA:Journal of the American Heart Association - March 14, 2017 Category: Cardiology Authors: Porras, A. M., van Engeland, N. C. A., Marchbanks, E., McCormack, A., Bouten, C. V. C., Yacoub, M. H., Latif, N., Masters, K. S. Tags: Basic Science Research, Valvular Heart Disease Original Research Source Type: research