JAHA:Journal of the American Heart Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

An Appraisal of Methods Recently Recommended for Testing Salt Sensitivity of Blood Pressure [Contemporary Review]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 1, 2017 Category: Cardiology Authors: Kurtz, T. W., DiCarlo, S. E., Pravenec, M., Morris, R. C. Tags: High Blood Pressure, Hypertension Contemporary Review Source Type: research

Benefits of Permanent His Bundle Pacing Combined With Atrioventricular Node Ablation in Atrial Fibrillation Patients With Heart Failure With Both Preserved and Reduced Left Ventricular Ejection Fraction [Heart Failure]
This study evaluated clinical outcomes of permanent HBP in atrial fibrillation patients with narrow QRS who underwent atrioventricular node ablation for heart failure symptoms despite rate control by medication.Methods and ResultsThe study enrolled 52 consecutive heart failure patients who underwent attempted atrioventricular node ablation and HBP for symptomatic atrial fibrillation. Echocardiographic left ventricular ejection fraction and left ventricular end‐diastolic dimension, New York Heart Association classification and use of diuretics for heart failure were assessed during follow‐up visits after permanent HBP. ...
Source: JAHA:Journal of the American Heart Association - April 1, 2017 Category: Cardiology Authors: Huang, W., Su, L., Wu, S., Xu, L., Xiao, F., Zhou, X., Ellenbogen, K. A. Tags: Arrhythmias, Heart Failure, Pacemaker Original Research Source Type: research

Use of p53-Silenced Endothelial Progenitor Cells to Treat Ischemia in Diabetic Peripheral Vascular Disease [Vascular Medicine]
ConclusionsTransient silencing of p53 using adenoviral vector in EPCs may have a therapeutic role in diabetic peripheral vascular disease. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 1, 2017 Category: Cardiology Authors: Kundu, N., Domingues, C. C., Chou, C., Ahmadi, N., Houston, S., Jerry, D. J., Sen, S. Tags: Gene Therapy, Stem Cells, Diabetes, Type 1, Diabetes, Type 2, Peripheral Vascular Disease Original Research Source Type: research

Prognostic Significance of Interleukin-34 (IL-34) in Patients With Chronic Heart Failure With or Without Renal Insufficiency [Heart Failure]
ConclusionsIL‐34 is a significant predictor of cardiovascular death, HF hospitalization, and all‐cause mortality in chronic HF, especially when concomitant with renal dysfunction. Serum IL‐34 measurement may provide new insights linking kidney impairment to poor HF outcomes beyond other renal markers. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 1, 2017 Category: Cardiology Authors: Tao, R., Fan, Q., Zhang, H., Xie, H., Lu, L., Gu, G., Wang, F., Xi, R., Hu, J., Chen, Q., Niu, W., Shen, W., Zhang, R., Yan, X. Tags: Biomarkers, Heart Failure, Prognosis Original Research Source Type: research

Bilirubin Prevents Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor-Deficient Mice by Inhibiting Endothelial VCAM-1 and ICAM-1 Signaling [Vascular Medicine]
ConclusionsBilirubin suppresses atherosclerotic plaque formation in Ldlr−/− mice by disrupting endothelial VCAM‐1‐ and ICAM‐1‐mediated leukocyte migration through the scavenging of reactive oxygen species signaling intermediaries. These findings suggest a potential mechanism for the apparent cardioprotective effects of bilirubin. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 1, 2017 Category: Cardiology Authors: Vogel, M. E., Idelman, G., Konaniah, E. S., Zucker, S. D. Tags: Endothelium/Vascular Type/Nitric Oxide, Vascular Biology, Atherosclerosis Original Research Source Type: research

Statin Treatment and Clinical Outcomes of Heart Failure Among Africans: An Inverse Probability Treatment Weighted Analysis [Heart Failure]
ConclusionsAmong Africans with HF, statin treatment was associated with significant reduction in mortality. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 1, 2017 Category: Cardiology Authors: Bonsu, K. O., Owusu, I. K., Buabeng, K. O., Reidpath, D. D., Kadirvelu, A. Tags: Clinical Studies, Epidemiology, Race and Ethnicity, Heart Failure, Treatment Original Research Source Type: research

Diagnostic Accuracy of 3.0-T Magnetic Resonance T1 and T2 Mapping and T2-Weighted Dark-Blood Imaging for the Infarct-Related Coronary Artery in Non-ST-Segment Elevation Myocardial Infarction [Imaging]
BackgroundPatients with recent non–ST‐segment elevation myocardial infarction commonly have heterogeneous characteristics that may be challenging to assess clinically.Methods and ResultsWe prospectively studied the diagnostic accuracy of 2 novel (T1, T2 mapping) and 1 established (T2‐weighted short tau inversion recovery [T2W‐STIR]) magnetic resonance imaging methods for imaging the ischemic area at risk and myocardial salvage in 73 patients with non–ST‐segment elevation myocardial infarction (mean age 57±10 years, 78% male) at 3.0‐T magnetic resonance imaging within 6.5±3.5 days of invasive management. T...
Source: JAHA:Journal of the American Heart Association - March 31, 2017 Category: Cardiology Authors: Layland, J., Rauhalammi, S., Lee, M. M. Y., Ahmed, N., Carberry, J., Teng Yue May, V., Watkins, S., McComb, C., Mangion, K., McClure, J. D., Carrick, D., O'Donnell, A., Sood, A., McEntegart, M., Oldroyd, K. G., Radjenovic, A., Berry, C. Tags: Magnetic Resonance Imaging (MRI) Original Research Source Type: research

Echocardiographic Pulmonary Artery Systolic Pressure in the Coronary Artery Risk Development in Young Adults (CARDIA) Study: Associations With Race and Metabolic Dysregulation [Imaging]
ConclusionsIn a large biracial cohort of middle‐aged adults, we identified associations among black race, insulin resistance, and diastolic dysfunction with higher echocardiographically estimated PASP. Further studies are needed to examine racial differences in PASP and whether insulin resistance directly contributes to pulmonary vascular disease in humans. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 30, 2017 Category: Cardiology Authors: Brittain, E. L., Nwabuo, C., Xu, M., Gupta, D. K., Hemnes, A. R., Moreira, H. T., De Vasconcellos, H. D., Terry, J. G., Carr, J. J., Lima, J. A. C. Tags: Risk Factors, Metabolic Syndrome, Pulmonary Hypertension, Echocardiography Original Research Source Type: research

Aortic Calcification Onset and Progression: Association With the Development of Coronary Atherosclerosis [Imaging]
ConclusionTAC and CAC share similar major determinants for incident calcification. Participants with TAC, especially ascending TAC, are at elevated risk for development of CAC. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 30, 2017 Category: Cardiology Authors: Kalsch, H., Lehmann, N., Moebus, S., Hoffmann, B., Stang, A., Jockel, K.–H., Erbel, R., Mahabadi, A. A. Tags: Cardiovascular Disease, Epidemiology, Computerized Tomography (CT), Atherosclerosis Original Research Source Type: research

Increased Arterial Stiffness is an Independent Predictor of Renal Function Decline in Patients With Type 2 Diabetes Mellitus Younger Than 60 Years [Kidney in Cardiovascular Disease]
ConclusionsAo‐PWV predicts eGFR decline, before the onset of advanced renal dysfunction, and is a potential target for renoprotection in younger patients with type 2 diabetes mellitus. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 30, 2017 Category: Cardiology Authors: Fountoulakis, N., Thakrar, C., Patel, K., Viberti, G., Gnudi, L., Karalliedde, J. Tags: Nephrology and Kidney, Vascular Disease Original Research Source Type: research

Dual Function for Mature Vascular Smooth Muscle Cells During Arteriovenous Fistula Remodeling [Vascular Medicine]
ConclusionsWe demonstrated a dual function for mature VSMCs in AVF remodeling, with differentiated VSMCs contributing to medial wall thickening towards venous maturation and dedifferentiated VSMCs contributing to neointimal hyperplasia. These results provide valuable insights into the mechanisms underlying venous adaptations during AVF remodeling. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 30, 2017 Category: Cardiology Authors: Zhao, J., Jourd'heuil, F. L., Xue, M., Conti, D., Lopez-Soler, R. I., Ginnan, R., Asif, A., Singer, H. A., Jourd'heuil, D., Long, X. Tags: Stenosis, Vascular Disease Original Research Source Type: research

Biomarker Profiles in Heart Failure Patients With Preserved and Reduced Ejection Fraction [Heart Failure]
BackgroundBiomarkers may help us to unravel differences in the underlying pathophysiology between heart failure (HF) patients with a reduced ejection fraction (HFrEF) and a preserved ejection fraction (HFpEF). Therefore, we compared biomarker profiles to characterize pathophysiological differences between patients with HFrEF and HFpEF.Methods and ResultsWe retrospectively analyzed 33 biomarkers from different pathophysiological domains (inflammation, oxidative stress, remodeling, cardiac stretch, angiogenesis, arteriosclerosis, and renal function) in 460 HF patients (21% HFpEF, left ventricular ejection fraction ≥45%) me...
Source: JAHA:Journal of the American Heart Association - March 30, 2017 Category: Cardiology Authors: Tromp, J., Khan, M. A. F., Klip, I. T., Meyer, S., de Boer, R. A., Jaarsma, T., Hillege, H., van Veldhuisen, D. J., van der Meer, P., Voors, A. A. Tags: Biomarkers, Mechanisms, Heart Failure, Remodeling Original Research Source Type: research

Impact of Diabetes Mellitus on the Pharmacodynamic Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Acute Coronary Syndrome Patients Undergoing Ad Hoc Percutaneous Coronary Intervention [Interventional Cardiology]
BackgroundDiabetes mellitus (DM) is associated with enhanced platelet reactivity and impaired response to oral antiplatelet therapy, including clopidogrel. This post hoc analysis investigated the pharmacodynamic effects of ticagrelor versus clopidogrel loading dose (LD) in troponin‐negative acute coronary syndrome patients with or without DM undergoing percutaneous coronary intervention in the Ad Hoc PCI study.Methods and ResultsPatients randomized (1:1) to receive ticagrelor 180 mg LD or clopidogrel 600 mg LD were assessed by diabetic status. Platelet reactivity (P2Y12 reaction units [PRU] on VerifyNow® assay) was me...
Source: JAHA:Journal of the American Heart Association - March 29, 2017 Category: Cardiology Authors: Sweeny, J. M., Angiolillo, D. J., Franchi, F., Rollini, F., Waksman, R., Raveendran, G., Dangas, G., Khan, N. D., Carlson, G. F., Zhao, Y., Teng, R., Mehran, R. Tags: Percutaneous Coronary Intervention, Treatment Original Research Source Type: research

Sex–Specific Relationship Between Serum Uric Acid and Risk of Stroke: A Dose–Response Meta–Analysis of Prospective Studies [Systematic Review and Meta-Analysis]
BackgroundConflicting findings of the association between serum uric acid (UA) and stroke have been reported in both men and women, and it is unclear whether this association was different between men and women. We preformed this meta‐analysis to assess the sex‐specific effect of serum UA on the risk of stroke and its subtypes.Methods and ResultsProspective studies that reported sex‐specific association of UA levels with stroke or reported in a certain sex were included. Dose‐response relationships were assessed by the generalized least squares trend estimation, and summary effect estimates were evaluated with rand...
Source: JAHA:Journal of the American Heart Association - March 29, 2017 Category: Cardiology Authors: Zhong, C., Zhong, X., Xu, T., , Zhang, Y. Tags: Risk Factors, Cerebrovascular Disease/Stroke, Ischemic Stroke Systematic Review and Meta ‐ Analysis Source Type: research

History of Periodontitis Diagnosis and Edentulism as Predictors of Cardiovascular Disease, Stroke, and Mortality in Postmenopausal Women [Epidemiology]
BackgroundFew studies have reported associations between periodontitis and cardiovascular disease (CVD) risk in older women, which is the objective of the present investigation.Methods and ResultsParticipants were 57 001 postmenopausal women ages 55 to 89 years (mean 68 years;>85% 60 and older) who were enrolled (1993–1998) in the Women's Health Initiative Observational Study, and were without known CVD when history of periodontitis and edentulism was assessed by questionnaire at study Year‐5 (1998–2003). There were 3589 incident CVD events and 3816 total deaths during a mean follow‐up of 6.7 years. In multivar...
Source: JAHA:Journal of the American Heart Association - March 29, 2017 Category: Cardiology Authors: LaMonte, M. J., Genco, R. J., Hovey, K. M., Wallace, R. B., Freudenheim, J. L., Michaud, D. S., Mai, X., Tinker, L. F., Salazar, C. R., Andrews, C. A., Li, W., Eaton, C. B., Martin, L. W., Wactawski-Wende, J. Tags: Aging, Cardiovascular Disease, Epidemiology, Women, Mortality/Survival Original Research Source Type: research