Dual Function for Mature Vascular Smooth Muscle Cells During Arteriovenous Fistula Remodeling [Vascular Medicine]

ConclusionsWe demonstrated a dual function for mature VSMCs in AVF remodeling, with differentiated VSMCs contributing to medial wall thickening towards venous maturation and dedifferentiated VSMCs contributing to neointimal hyperplasia. These results provide valuable insights into the mechanisms underlying venous adaptations during AVF remodeling.

Source: JAHA:Journal of the American Heart Association - March 30, 2017 Category: Cardiology Authors: Zhao, J., Jourd'heuil, F. L., Xue, M., Conti, D., Lopez-Soler, R. I., Ginnan, R., Asif, A., Singer, H. A., Jourd'heuil, D., Long, X. Tags: Stenosis, Vascular Disease Original Research Source Type: research