Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Inȷury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening [Molecular Cardiology]

ConclusionsThis evidence clearly illustrates that microcirculatory ischemia/reperfusion injury can be attributed to Mff‐dependent mitochondrial fission via voltage‐dependent anion channel 1/hexokinase 2–mediated mitochondrial permeability transition pore opening and mitochondrial reactive oxygen species/cardiolipin involved cyt‐c release.

Source: JAHA:Journal of the American Heart Association - March 13, 2017 Category: Cardiology Authors: Zhou, H., Hu, S., Jin, Q., Shi, C., Zhang, Y., Zhu, P., Ma, Q., Tian, F., Chen, Y. Tags: Coronary Circulation, Basic Science Research, Cell Biology/Structural Biology, Endothelium/Vascular Type/Nitric Oxide, Vascular Biology Original Research Source Type: research