Divergent Effects of miR-181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets [Molecular Cardiology]

ConclusionsThe miR‐181 family alters the myocardial response to oxidative stress, notably with detrimental effects by targeting mt‐COX1 (miR‐181c) or with protection by targeting PTEN (miR‐181a/b).

http://jaha.ahajournals.org/content/6/3/e004694.short?rss=1

Source: JAHA:Journal of the American Heart Association - February 27, 2017 Category: Cardiology Authors: Das, S., Kohr, M., Dunkerly-Eyring, B., Lee, D. I., Bedȷa, D., Kent, O. A., Leung, A. K. L., Henao-Meȷia, J., Flavell, R. A., Steenbergen, C. Tags: Cell Signaling/Signal Transduction, Ischemia, Oxidant Stress, Genetically Altered and Transgenic Models, Myocardial Infarction Original Research Source Type: research