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Endobronchial tuberculosis presented as multiple endobronchial vesicular lesions
Publication date: Available online 2 April 2015 Source:International Journal of Mycobacteriology Author(s): Farah Idrees , Saima Kamal , Muhammad Irfan , Rashida Ahmed Endobronchial tuberculosis (EBTB) is a tuberculous infection of the tracheobronchial tree with microbiological and histopathological evidence, with or without parenchymal involvement. EBTB commonly presents as acute or insidious onset cough, wheeze, low grade fever, and constitutional symptoms. In elderly patients, other differentials like malignancy and pneumonia may lead to misdiagnosis. Hence, bronchoscopy is essential for confirmation of EBTB. He...
Source: International Journal of Mycobacteriology - April 3, 2015 Category: Infectious Diseases Source Type: research

Medicinal plants used to treat TB in Ghana
Conclusions The collected plant species could be a source of a new class of drugs against TB. Bioactivity guided fractionation is recommended to identify lead compounds for antimycobacterial activity. The current paper documents for the first time medicinal plant species used by Ghanaian communities to treat TB. These results are a basis for selection of plants for further pharmacological, toxicological and phytochemical studies in developing new plant-based antimycobacterial drugs. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - March 28, 2015 Category: Infectious Diseases Source Type: research

Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors
Conclusions This study describes the discovery of benzothiazinone as gyrase inhibitors with potent MTB MIC and inhibitory profiles of the gyrase enzyme with less cytotoxic effect. Furthermore, it is believed that this class of compounds has the potential to be further developed as an anti-TB drug candidate. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - March 27, 2015 Category: Infectious Diseases Source Type: research

E84G mutation in dihydrofolate reductase from drug resistant strains of Mycobacterium tuberculosis (Mumbai, India) leads to increased interaction with Trimethoprim
Conclusions The Glu84Gly point mutation may lead to a variation in the strain which may cause resistance in the future. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - March 13, 2015 Category: Infectious Diseases Source Type: research

Comparative evaluation of PCR amplification of RLEP, 16S rRNA, rpoT and Sod A gene targets for detection of M. leprae DNA from clinical and environmental samples
Conclusion Amongst all the gene targets used in this study, PCR positivity using RLEP gene target was the highest in all the clinical and environmental samples. Further, the RLEP gene target was able to detect 53% of blood samples as positive in BI-negative leprosy cases indicating its future standardization and use for diagnostic purposes. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - February 22, 2015 Category: Infectious Diseases Source Type: research