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The new therapeutic herbal drug HM0601 and its bioactive compound rutin exert potent antiproliferative activities in mast cells
In conclusion, these results indicate that HM0601 can be used as a new therapeutic herbal drug for prevention and therapeutic intervention of allergic inflammatory diseases. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - March 9, 2018 Category: Drugs & Pharmacology Authors: Hyun ‐Ja Jeong, Myoung‐Schook Yoou, Na‐Ra Han, Sung Yeoun Hwang, Kyoung Wan Yoon, Hyung‐Min Kim Tags: Original Article Source Type: research

Anti ‐inflammatory effect of 4‐methylcyclopentadecanone in rats submitted to ischemic stroke
This study aimed to investigate the anti‐inflammatory effect of 4‐methylcyclopentadecanone (4‐MCPC) in rats suffering from a cerebral ischemia/reperfusion (I/R) injury. In this study, the focal cerebral ischemia in rats was induced by middle cerebral artery occlusion (MCAO) for 2 h, and the rats were treated with 4‐MCPC (8 mg/kg) just 0.5 h before reperfusion. The ischemic infarct volume was recorded 24 h after the MCAO. In addition, myeloperoxidase (MPO) activity and TNF‐α and IL‐1β levels in the ischemic cerebral cortex were determined by ELISA, while nuclear translocation of NF‐κB p65 subunit and ex...
Source: Fundamental and Clinical Pharmacology - March 9, 2018 Category: Drugs & Pharmacology Authors: Yan Jin, Fang Wei, Xiaoli Dai, Min Qi, Yukui Ma Tags: Original Article Source Type: research

Multiple pharmacological approaches on Fibigia eriocarpa extracts by in vitro and computational assays
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - March 5, 2018 Category: Drugs & Pharmacology Authors: Gokhan Zengin, Devina Lobine, Adriano Mollica, Marcello Locatelli, Simone Carradori, Mohamad Fawzi Mahomoodally Tags: Original Article Source Type: research

Melatonin attenuates homocysteine ‐induced injury in human umbilical vein endothelial cells
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 13, 2018 Category: Drugs & Pharmacology Authors: Azadeh Aminzadeh, Saeed Mehrzadi Tags: Original Article Source Type: research

mRNA expression of drug metabolism enzymes and transporter genes at birth using human umbilical cord blood
This study aimed to characterize mRNA expression of the main drug metabolizing enzymes and transport proteins involved in drug disposition, using umbilical cord blood (UCB), according to gender, gestational age and genetic background. A large panel of genes was quantified: cytochrome P450 system (n=12), UGT family (n=6), TPMT and transporters (n=3), in 56 samples of UCB of twin neonates. Gene expression was measured using real‐time reverse‐transcription polymerase chain reaction with 18S rRNA as the endogenous control for normalization of data. Relative expression of the samples was expressed using the 2‐ΔΔCt metho...
Source: Fundamental and Clinical Pharmacology - February 13, 2018 Category: Drugs & Pharmacology Authors: Virginia Neyro, Val éry Elie, Yves Médard, Evelyne Jacqz‐Aigrain Tags: Original Article Source Type: research

Treating hepatic encephalopathy in cirrhotic patients admitted to ICU with sodium phenylbutyrate: a preliminary study
Fundamental&Clinical Pharmacology,Volume 32, Issue 2, Page 206-208, April 2018. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 11, 2018 Category: Drugs & Pharmacology Source Type: research

Imoxin attenuates high fructose induced oxidative stress and apoptosis in renal epithelial cell via downregulation of PKR Pathway
In conclusion our study demonstrates PKR induces oxidative stress and apoptosis, a significant contributor involved in vascular complications and a possible mediator of HF induced hypertension. Inhibition of PKR pathway can be used as a therapeutic strategy for the treatment of cardiovascular and metabolic disorders. This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 11, 2018 Category: Drugs & Pharmacology Authors: Jaspreet Kalra, Suresh Babu Mangali, Audesh Bhat, Indu Dhar, Mary Priyanka Udumula, Arti Dhar Tags: Original Article Source Type: research

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Fundamental&Clinical Pharmacology, Ahead of Print. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 1, 2018 Category: Drugs & Pharmacology Source Type: research

PAR1 contribution in acute electrophysiological properties of oral anticoagulants in rabbit pulmonary vein sleeve preparations
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 1, 2018 Category: Drugs & Pharmacology Authors: Jonaz Font, Mathilda Simeon, Christophe Simard, St éphane Allouche, Anne‐Flore Plane, Virginie Ferchaud, Marie Brionne, René Rouet, Marie Nowoczyn, Alain Manrique, Paolo Emilio Puddu, Paul Milliez, Joachim Alexandre Tags: Original Article Source Type: research

Metformin ameliorates the age ‐related changes of D‐galactose administration in ovariectomized mice
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 1, 2018 Category: Drugs & Pharmacology Authors: Iman Fatemi, Sara Heydari, Ayat Kaeidi, Ali Shamsizadeh, Elham Hakimizadeh, Amin Khaluoi, Mohammad Allahtavakoli Tags: Original Article Source Type: research

Comparison of adherence to generic multi ‐tablet regimens versus brand multi‐tablet and brand single‐tablet regimens likely to incorporate generic antiretroviral drugs by breaking or not fixed‐dose combinations in HIV‐infected patients
In conclusion, adherence to generic MTR was high and comparable with adherence to brand MTR and to STR. Utilization of DDD instead DNT to measure the MPR led to small but non‐significant difference that has no clinical impact. This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 1, 2018 Category: Drugs & Pharmacology Authors: Joseph Rwagitinywa, Maryse Lapeyre ‐Mestre, Robert Bourrel, Jean‐Louis Montastruc, Agnès Sommet Tags: Original Article Source Type: research

Protective effect of melatonin in the diabetic rat retina
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 1, 2018 Category: Drugs & Pharmacology Authors: Saeed Mehrzadi, Manijeh Motevalian, Mozhgan Rezaei Kanavi, Iman Fatemi, Habib Ghaznavi, Mansoor Shahriari Tags: Original Article Source Type: research

Involving Children and Young People in Clinical Research through the forum of a European Young Persons ’ Advisory Group: Needs & Challenges
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 1, 2018 Category: Drugs & Pharmacology Authors: Segolene Gaillard, Salma Malik, Jenny Preston, Begonya Nafria Escalera, Pamela Dicks, Nathalie Touil, Sandrine Mardirossian, Joana Claverol ‐Torres, Behrouz Kassaï Tags: Review Article Source Type: research