Fundamental and Clinical Pharmacology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Angiotensin ‐converting enzyme 2–Angiotensin 1‐7/1‐9 system: novel promising targets for heart failure treatment
Abstract
Cardiac remodeling (cardiac hypertrophy and fibrosis) is a hallmark of heart failure (HF). It can be induced by the abnormal elevation of several endogenous factors including angiotensin II (Ang II), which is generated from its precursor angiotensin I (Ang I) by the action of angiotensin‐converting enzyme. The inhibition of this enzyme or the blockade of the Ang II receptors demonstrated a high clinical value against the progression of HF. Ang I and Ang II may also be converted into angiotensin 1‐7 (Ang 1‐7) and angiotensin 1‐9 (Ang 1‐9), respectively, by the action of angiotensin‐converting enzyme 2. ...
Source: Fundamental and Clinical Pharmacology - December 1, 2017 Category: Drugs & Pharmacology Authors: Naim Kittana Tags: Review Article Source Type: research
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Fundamental&Clinical Pharmacology, Ahead of Print. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 29, 2017 Category: Drugs & Pharmacology Source Type: research
Melatonin therapy reduces the risk of osteoporosis and normalizes bone formation in multiple sclerosis
This study investigated, using ELISA, the clinical correlation between serum melatonin and proCT in MS patients. We then assessed the effect of melatonin (10mg/kg) therapy on bone metabolism and osteoporosis in experimental autoimmune encephalomyelitis (EAE) model of MS and in MS patients.
Data showed a significant increase (*p<0.05) in serum levels of proCT in MS patients, inversely correlated (r = −0.945; p = 0.0001) to melatonin levels, compared to healthy participants. On the other hand, melatonin therapy ameliorated EAE severity by significantly decreasing (*p<0.05) mean clinical scores, compared to co...
Source: Fundamental and Clinical Pharmacology - November 28, 2017 Category: Drugs & Pharmacology Authors: Majid Ghareghani, Linda Scavo, Damien Arnoult, Kazem Zibara, Naser Farhadi Tags: Short Communication Source Type: research
Melatonin therapy reduces the risk of osteoporosis and normalizes bone formation in multiple sclerosis
Fundamental&Clinical Pharmacology,Volume 32, Issue 2, Page 181-187, April 2018. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 28, 2017 Category: Drugs & Pharmacology Source Type: research
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Fundamental&Clinical Pharmacology, Ahead of Print. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 27, 2017 Category: Drugs & Pharmacology Source Type: research
The Role of Nonsteroidal Anti ‐inflammatory Drugs (NSAIDs) Intramuscular Injection in the Development and Severity of Deep Soft Tissue Infection in Mice
In conclusion, DS injection prior to bacterial inoculation might predispose to bacteremia and sepsis.
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 25, 2017 Category: Drugs & Pharmacology Authors: Zeynep Ture, Hayati Demiraslan, Olgun Kontas, Emine Alp, Mehmet Doganay Tags: Original Article Source Type: research
Comparative study of amlodipine vs. cilnidipine for the prevention of hepatic ischemia ‐reperfusion injury in rat model
Fundamental&Clinical Pharmacology,Volume 32, Issue 2, Page 163-173, April 2018. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 24, 2017 Category: Drugs & Pharmacology Source Type: research
The role of nonsteroidal anti ‐inflammatory drugs intramuscular injection in the development and severity of deep soft tissue infection in mice
Fundamental&Clinical Pharmacology,Volume 32, Issue 2, Page 147-154, April 2018. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 24, 2017 Category: Drugs & Pharmacology Source Type: research
Comparative Study of Amlodipine versus Cilnidipine for the Prevention of Hepatic Ischemia ‐Reperfusion Injury in Rat Model
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 24, 2017 Category: Drugs & Pharmacology Authors: Abdel ‐Motaal M. Fouda, Amany Ragab Youssef, Osama Sharaf Eldin Tags: Original Article Source Type: research
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Fundamental&Clinical Pharmacology, Ahead of Print. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 23, 2017 Category: Drugs & Pharmacology Source Type: research
Exenatide upregulates gene expression of glucagon ‐like peptide‐1 receptor and nerve growth factor in streptozotocin/nicotinamide‐induced diabetic mice
Abstract
Glucagon‐like peptide‐1 (GLP‐1) is an incretin hormone that has modulating effects on insulin release. GLP‐1 and receptors for GLP‐1 are widely expressed throughout the body including the brain. The expression of GLP‐1 receptors is very specific to large neurons in hippocampus, neocortex, and cerebellum. GLP‐1 receptor stimulation enhances glucose‐dependent insulin secretion and lowers blood glucose in type 2 diabetes mellitus. Studies on adipobiology of neurotrophins have focused on nerve growth factor (NGF) as an example of adipose‐derived neurotrophins. Compromised trophic factor signaling may...
Source: Fundamental and Clinical Pharmacology - November 20, 2017 Category: Drugs & Pharmacology Authors: Esen Gumuslu, Naci Cine, Merve Ertan, Oguz Mutlu, Ipek Komsuoglu Celikyurt, Guner Ulak Tags: Original Article Source Type: research
SGLT ‐2 inhibitors and ketoacidosis: a disproportionality analysis in the World Health Organization's adverse drug reactions database
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 16, 2017 Category: Drugs & Pharmacology Authors: Abdel Nasser Ado Moumouni, Perrine Robin, Dominique Hillaire ‐Buys, Jean‐Luc Faillie Tags: Original Article Source Type: research
Detection of adverse drug reactions: evaluation of an automatic data processing applied in oncology performed in the French DRG database
This study focused on adverse drug reaction which required inpatient hospitalization (ADRh). All diagnoses coded in the DRG database for hospital stays that occurred within three months after OTT initiation were collected (potential ADRh). Filters (exclusion criteria) were automatically applied on potential ADRh in order to exclude diagnoses that were not adverse drug reactions (false positives). A pharmacovigilance review was carried out to identify ADRh in the medical records (reported ADRh). The sensitivity and specificity of the detection method were estimated for each filter combinations by comparison between potentia...
Source: Fundamental and Clinical Pharmacology - November 16, 2017 Category: Drugs & Pharmacology Authors: Alexandre Quillet, Olivier Colin, Nicolas Bourgeois, Sylvie Favreli ère, Aurélie Ferru, Laurence Boinot, Claire Lafay‐Chebassier, Marie‐Christine Perault‐Pochat Tags: Original Article Source Type: research
SGLT ‐2 inhibitors and ketoacidosis: a disproportionality analysis in the World Health Organization's adverse drug reactions database
Fundamental&Clinical Pharmacology,Volume 32, Issue 2, Page 216-226, April 2018. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 16, 2017 Category: Drugs & Pharmacology Source Type: research
