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Pretreatment with melatonin protects against cyclophosphamide ‐induced oxidative stress and renal damage in mice
This study was carried out to investigate the effect of melatonin (MEL) on CP‐induced nephrotoxicity in mice. In this study, 50 Swiss albino mice (20–25 g) were randomly divided into five groups. Mice were pretreated with MEL intraperitoneally (i.p) in doses of 5, 10 and 20 mg/kg for five consecutive days, and CP (200 mg/kg, i.p) was administrated on the 5th day 1 h after the last dose of MEL. Then on day 6, blood samples were collected to determine serum creatinine (Cr) and blood urea nitrogen (BUN) levels. The kidneys were used for histological examination, biochemical assays and real‐time PCR studies. Malondia...
Source: Fundamental and Clinical Pharmacology - July 31, 2017 Category: Drugs & Pharmacology Authors: Mehdi Goudarzi, Mohammad Javad Khodayar, Seyed Mohammad Taghi Hosseini Tabatabaei, Habib Ghaznavi, Iman Fatemi, Saeed Mehrzadi Tags: Original Article Source Type: research

Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K+ currents expressed in HEK293 cells
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - July 29, 2017 Category: Drugs & Pharmacology Authors: Tao Song, Yuanyuan Zhang, Qiongtao Song, Xue Han, Shengjiang Guan, Xuan Zhang, Xi Chu, Fenghua Zhang, Jianping Zhang, Li Chu Tags: Short Communication Source Type: research

Potential of telmisartan in the treatment of benign prostatic hyperplasia
This study was carried out to investigate the protective effect of telmisartan on testosterone induced‐BPH in rats. Fifty‐four male Wistar rats (200 ‐ 250g) were randomly divided into 9 groups (n =6) and orally treated for 28 consecutive days: group 1‐ vehicle normal, olive oil (10 ml/kg); group 2‐ BPH model control (10 ml/kg); groups 3‐5 ‐ telmisartan (5, 10 or 20 mg/kg, respectively); group 6‐ pioglitazone (20 mg/kg); group 7‐ celecoxib (20 mg/kg); group 8‐ combination of telmisartan (5 mg/kg) and pioglitazone (20 mg/kg); group 9‐ combination of telmisartan (5 mg/kg) and celecoxib (20 mg/kg). Animal...
Source: Fundamental and Clinical Pharmacology - July 21, 2017 Category: Drugs & Pharmacology Authors: Ismail Ogunbayode Ishola, Charles C. Anunobi, Kehinde Habeeb Tijani, Olasunmbo Afolayan, Victoria U. Udokwu Tags: Original Article Source Type: research

Branched chain amino acids supplementation modulates TGF ‐β1/Smad signaling pathway and interleukins in CCl4‐induced liver fibrosis
Abstract The alterations and low levels of circulating branched chain amino acids (BCAAs), leucine, isoleucine, and valine, are associated with liver diseases. The study was designed to evaluate hepatoprotective effect of BCAAs on CCl4‐induced liver fibrosis and to investigate the molecular mechanisms underlying these effects in rats. In all, 30 male rats were divided into three groups. Control group (n = 10) and CCl4 group (n = 10), where rats were injected with CCl4 (1 mL/kg of 0.5 : 1 v/v injected i.p. twice weekly for 12 weeks). In CCl4 + BCAAs group (n = 10), rats were injected with similar doses of CCl4 and supplem...
Source: Fundamental and Clinical Pharmacology - July 19, 2017 Category: Drugs & Pharmacology Authors: Naglaa F. Khedr, Eman G. Khedr Tags: Original Article Source Type: research

Pre ‐treatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice
This study was done to investigate the effect of melatonin (MEL) on CP‐induced nephrotoxicity in mice. In this study, 50 Swiss albino mice (20–25 g) were randomly divided into five groups. Mice were pretreated with MEL intraperitoneally (i.p) in doses of 5, 10 and 20 mg/kg for 5 consecutive days and CP (200 mg/kg, i.p) was administrated on the 5th day 1 hour after the last dose of MEL. Then on day 6, blood samples were collected to determine serum creatinine (Cr) and blood urea nitrogen (BUN) levels. The kidneys were used for histological examination, biochemical assays and real time PCR studies. Malondialdehyde (MDA),...
Source: Fundamental and Clinical Pharmacology - July 10, 2017 Category: Drugs & Pharmacology Authors: Mehdi Goudarzi, Mohammad Javad Khodayar, Seyed Mohammad Taghi Hosseini Tabatabaei, Habib Ghaznavi, Iman Fatemi, Saeed Mehrzadi Tags: Original Article Source Type: research

Atorvastatin attenuates testosterone ‐induced benign prostatic hyperplasia in rats: role of peroxisome proliferator‐activated receptor‐γ and cyclo‐oxygenase‐2
In this study, an attempt was made to investigate the protective effect of atorvastatin (ATR) in combination with celecoxib (CEL) or pioglitazone (PIO) on testosterone‐induced BPH in rats. Male Wistar rats (200–250 g) were randomly divided into nine groups (n = 8) and orally treated as follows for 28 consecutive days: group 1: vehicle control (10 mL/kg); group 2: vehicle testosterone (10 mL/kg); groups 3 ‐ 5: ATR (0.5, 2.5, and 5 mg/kg, respectively); group 6: CEL (20 mg/kg); group 7: PIO (20 mg/kg); and groups 8–9: ATR 0.5 mg/kg, and 15 min later, animals were given CEL (20 mg/kg) or PIO (20 mg/kg), respectively. ...
Source: Fundamental and Clinical Pharmacology - July 10, 2017 Category: Drugs & Pharmacology Authors: Ismail O. Ishola, Habeeb K. Tijani, Olufunke O. Dosumu, Charles C. Anunobi, Tolulope O. Oshodi Tags: Original Article Source Type: research

Naloxone prolongs cutaneous nociceptive block by lidocaine in rats
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Source: Fundamental and Clinical Pharmacology - July 5, 2017 Category: Drugs & Pharmacology Authors: Yu ‐Wen Chen, Ja‐Ping Shieh, Kuo‐Sheng Liu, Jhi‐Joung Wang, Ching‐Hsia Hung Tags: Original Article Source Type: research

Corrigendum
(Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - July 4, 2017 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: research

Issue Information
(Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - July 4, 2017 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Trends in the incidence of use of noninsulin glucose ‐lowering drugs between 2006 and 2013 in France
In conclusion, after reaching a peak in 2010, the incidence of use of NIGLDs has markedly decreased in France. Since then, prescribers seem to have reverted to older and well‐known therapies. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - June 28, 2017 Category: Drugs & Pharmacology Authors: Mickael Arnaud, Julien Bezin, Bernard B égaud, Antoine Pariente, Francesco Salvo Tags: Original Article Source Type: research

Atorvastatin attenuates testosterone induced benign prostatic hyperplasia in rats: role of peroxisome proliferator activated receptor ‐γ and cyclo‐oxygenase‐2
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - June 1, 2017 Category: Drugs & Pharmacology Authors: Ismail O. Ishola, Habeeb K. Tijani, Olufunke O. Dosumu, Charles C. Anunobi, Tolulope O. Oshodi Tags: Original Article Source Type: research

Is Bisphenol A an environmental obesogen?
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - June 1, 2017 Category: Drugs & Pharmacology Authors: Samuel Legeay, S ébastien Faure Tags: Review Article Source Type: research

Trends in the incidence of use of non ‐insulin glucose‐lowering drugs between 2006 and 2013 in France
In conclusion, after reaching a peak in 2010, the incidence of use of NIGLDs has markedly decreased in France. Since then, prescribers seem to have reverted to older and well‐known therapies. This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - June 1, 2017 Category: Drugs & Pharmacology Authors: Mickael Arnaud, Julien Bezin, Bernard B égaud, Antoine Pariente, Francesco Salvo Tags: Original Article Source Type: research

Epigallocatechin ‐3‐gallate ameliorates intrahepatic cholestasis of pregnancy by inhibiting matrix metalloproteinase‐2 and matrix metalloproteinase‐9
Abstract Matrix metalloproteinase (MMP)‐2 and matrix metalloproteinase‐9 are involved in many illnesses affecting pregnant women, including intrahepatic cholestasis of pregnancy (ICP), a serious liver abnormality during pregnancy. Epigallocatechin‐3‐gallate (EGCG) has been widely reported to inhibit activities of MMP‐2 and MMP‐9. We aimed to investigate the role of EGCG in ameliorating ICP symptoms in a rat model. Using 17α‐ethinylestradiol to induce ICP in pregnant rats, we investigated the efficacy of EGCG administration on ICP symptoms, including bile flow rate, total bile acids (TBA) and MMP‐2 and MMP�...
Source: Fundamental and Clinical Pharmacology - May 24, 2017 Category: Drugs & Pharmacology Authors: Mei Zhang, Meimei Xu Tags: Original Article Source Type: research

Further analysis of acute antinociceptive and anti ‐inflammatory actions of 4‐phenylselenyl‐7‐chloroquinoline in mice
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Source: Fundamental and Clinical Pharmacology - May 23, 2017 Category: Drugs & Pharmacology Authors: Vanessa D. G. Silva, Ang élica S. Reis, Mikaela Pinz, Caren A. R. da Fonseca, Luis Fernando B. Duarte, Juliano A. Roehrs, Diego Alves, Cristiane Luchese, Ethel A. Wilhelm Tags: Original Article Source Type: research