Fundamental and Clinical Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Dexmedetomidine Enhances Human Lung Fluid Clearance through Improving Alveolar Sodium Transport
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 31, 2017 Category: Drugs & Pharmacology Authors: Yong Cui, Yan Ding, Lei Chen, Yue Li, Yan Chun Li, Hongguang Nie Tags: Original Article Source Type: research

Evidence for the role of histaminergic pathways in neuroprotective mechanism of ischemic postconditioning in mice
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 31, 2017 Category: Drugs & Pharmacology Authors: Indresh Kaur, Amit Kumar, Amteshwar S. Jaggi, Nirmal Singh Tags: Original Article Source Type: research

Uptake and efflux kinetics, and intracellular activity of voriconazole against Aspergillus fumigatus in human pulmonary epithelial cells: a new application for the prophylaxis and early treatment of invasive pulmonary aspergillosis
This study illustrated a new application for the prophylaxis and early treatment of IPA from the cellular pharmacokinetics and pharmacodynamics and emphasized the importance of monitoring concentrations of voriconazole in epithelial lining fluid in immunocompromised patients receiving voriconazole therapy. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 24, 2017 Category: Drugs & Pharmacology Authors: Taotao Wang, Qianting Yang, Lu Chen, Ying Li, Ti Meng, Yan Wang, Tao Zhang, Jin'e Lei, Jianfeng Xing, Yalin Dong Tags: Original Article Source Type: research

Analysis of temozolomide resistance in low ‐grade gliomas using a mechanistic mathematical model
Abstract Understanding how tumors develop resistance to chemotherapy is a major issue in oncology. When treated with temozolomide (TMZ), an oral alkylating chemotherapy drug, most low‐grade gliomas (LGG) show an initial volume decrease but this effect is rarely long lasting. In addition, it has been suggested that TMZ may drive tumor progression in a subset of patients as a result of acquired resistance. Using longitudinal tumor size measurements from 121 patients, the aim of this study was to develop a semi‐mechanistic mathematical model to determine whether resistance of LGG to TMZ was more likely to result from prim...
Source: Fundamental and Clinical Pharmacology - January 23, 2017 Category: Drugs & Pharmacology Authors: Edouard Ollier, Pauline Mazzocco, Damien Ricard, Gentian Kaloshi, Ahmed Idbaih, Agusti Alentorn, Dimitri Psimaras, J érôme Honnorat, Jean‐Yves Delattre, Emmanuel Grenier, François Ducray, Adeline Samson Tags: Original Article Source Type: research

Enhanced TRPC channel ‐mediated Ca2+ influx in the cells with phospholipase C‐δ1 overexpression: Its possible role in coronary artery spasm
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 21, 2017 Category: Drugs & Pharmacology Authors: Kazuo Murakami, Tomohiro Osanai, Makoto Tanaka, Kimitaka Nishizaki, Takahiko Kinjo, Tomohiro Tanno, Yuji Ishida, Akiko Suzuki, Tomohide Endo, Hirofumi Tomita, Ken Okumura Tags: Original Article Source Type: research

Amlodipine, an L ‐type calcium channel blocker, protects against chlorpromazine‐induced neurobehavioural deficits in mice
In conclusion, data from this study suggest possible chemopreventive benefit of AML alone or in combination with BMC against CPZ associated neurobehavioural deficits. The ameliorative effect of AML may be related to its antioxidant and/or calcium channel blocking property. This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 19, 2017 Category: Drugs & Pharmacology Authors: Oluwafemi E. Kale, Olufunsho Awodele, Temitope O. Ogundare, Martins Ekor Tags: Original Article Source Type: research

Protective effect of N,N ’‐dimethylthiourea against stress‐induced gastric mucosal lesions in rats
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 19, 2017 Category: Drugs & Pharmacology Authors: Yoshiji Ohta, Koji Yashiro, Takashi Kobayashi, Kazuo Inui, Junji Yoshino Tags: Original Article Source Type: research

Targeting nasopharyngeal carcinoma by artesunate through inhibiting Akt/mTOR and inducing oxidative stress
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 12, 2017 Category: Drugs & Pharmacology Authors: Qin Li, Wei Ni, Zhifeng Deng, Minghe Liu, Lazhi She, Qiong Xie Tags: Original Article Source Type: research

Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, inhibits L ‐type Ca2+ channels and contractility in rat ventricular myocytes
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 10, 2017 Category: Drugs & Pharmacology Authors: Tao Song, Xi Chu, Xuan Zhang, Qiong tao Song, Ying Zhang, Yuanyuan Zhang, Xue Han, Jianping Zhang, Li Chu Tags: Short Communication Source Type: research

Issue Information
(Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 9, 2017 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta ‐analysis:GLUCOSE DINET protocol ‐ Rational and design
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - December 29, 2016 Category: Drugs & Pharmacology Authors: Guillaume Grenet, Audrey Lajoinie, Shams Ribault, Gia Bao Nguyen, Thomas Linet, Augustin Metge, Catherine Cornu, Michel Cucherat, Philippe Moulin, Fran çois Gueyffier Tags: Review Article Source Type: research

Hypertension and pregnancy: expert consensus statement from the French Society of Hypertension, an affiliate of the French Society of Cardiology
Abstract High blood pressure in pregnancy remains, by its complications, the leading cause of morbidity as well as maternal and fetal mortality. The frequency (5–10% of pregnancies) and the potential severity of this disease, for both mother and child, encourage to standardize and to optimize our medical practices. If the short‐term complications for the mother and child are well known, long‐term ones for the mother are beginning to be better identified. The onset of hypertension during pregnancy disrupts the classic organization of health care and requires the intervention of the general practitioner and/or an obste...
Source: Fundamental and Clinical Pharmacology - December 20, 2016 Category: Drugs & Pharmacology Authors: Claire Mounier ‐Vehier, Jacques Amar, Jean‐Marc Boivin, Thierry Denolle, Jean‐Pierre Fauvel, Geneviève Plu‐Bureau, Vassilis Tsatsaris, Jacques Blacher Tags: Original Article Source Type: research

Can drugs induce or aggravate Sleep Apneas? A case non case Study in Vigibase ®, the WHO Pharmacovigilance Database
This study suggests that SAS can be associated to some drugs (mainly psychotropics) that are able to reveal or aggravate such a disease. Physicians should take into account the role of drugs in the etiological appraisal and management of SAS. This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 30, 2016 Category: Drugs & Pharmacology Authors: M élanie Linselle, Agnès Sommet, Emmanuelle Bondon‐Guitton, Florence Moulis, Geneviève Durrieu, Justine Benevent, Vanessa Rousseau, Leila Chebane, Haleh Bagheri, François Montastruc, Jean‐Louis Montastruc Tags: Original Article Source Type: research

Uptake and efflux kinetics, and intracellular activity of voriconazole against A. fumigatus in human pulmonary epithelial cells: a new application for the prophylaxis and early treatment of invasive pulmonary aspergillosis
This study illustrated a new application for the prophylaxis and early treatment of IPA from the cellular pharmacokinetics and pharmacodynamics, and emphasized the importance of monitoring concentrations of voriconazole in epithelial lining fluid in immunocompromised patients receiving voriconazole therapy. This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 30, 2016 Category: Drugs & Pharmacology Authors: Taotao Wang, Qianting Yang, Lu Chen, Ying Li, Ti Meng, Yan Wang, Tao Zhang, Jin'e Lei, Jianfeng Xing, Yalin Dong Tags: Original Article Source Type: research

Severe excessive daytime sleepiness induced by hydroxyurea
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - November 30, 2016 Category: Drugs & Pharmacology Authors: Bruno RevoL, Marie Joyeux ‐Faure, Marie‐Victoire Albahary, Remy Gressin, Michel Mallaret, Jean‐Louis Pepin, Sandrine H. Launois Tags: Case Report Source Type: research