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Positive predictive values of peripheral arterial and venous thrombosis codes in French hospital database
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - October 21, 2017 Category: Drugs & Pharmacology Authors: Mandy Prat, H élène Derumeaux, Laurent Sailler, Maryse Lapeyre‐Mestre, Guillaume Moulis Tags: Original Article Source Type: research

Population pharmacokinetics of oral baclofen at steady ‐state in alcoholic‐dependent adult patients
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - October 1, 2017 Category: Drugs & Pharmacology Authors: Lucie Chevillard, Naomi Sabo, Michel Tod, Laurence Labat, C éline Chasport, Céline Chevaleyre, Florence Thibaut, Jérôme Barré, Julien Azuar, Franck Questel, Florence Vorspan, Vanessa Bloch, Frank Bellivier, Bernard Granger, Camille Barrault, Xavier D Tags: Original Article Source Type: research

Factors associated with the variability of CNI blood levels in kidney recipients grafted for more than 1 year
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - October 1, 2017 Category: Drugs & Pharmacology Authors: St éphanie Belaiche, Bertrand Décaudin, Sébastien Dharancy, Sophie Gautier, Christian Noel, Pascal Odou, Marc Hazzan Tags: Original Article Source Type: research

Oligomeric proanthocyanidins protect myocardium by mitigating left ventricular remodeling in Isoproterenol induced Post ‐myocardial infarction
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - October 1, 2017 Category: Drugs & Pharmacology Authors: Ashokkumar Rathinavel, Jamuna Sankar, M. S Sakeena Sadullah, Sivasithamparam Niranjali Devaraj Tags: Original Article Source Type: research

Drug monitoring of sunitinib in patients with advanced solid tumors: a monocentric observational French study
This study aimed to determine a threshold value of plasma drug exposure associated with the occurrence of grade 3‐4 toxicity, then the potential impact of TDM on clinical decision. Consecutive outpatients treated with sunitinib were prospectively monitored between days 21‐28 of the first cycle, then monthly until disease progression. At each consultation, the composite AUCƬ,ss (sunitinib + active metabolite SU12662) was assayed. The decisions taken during each consultation were matched with AUCƬ,ss and compared to the decisional algorithm based on TDM. 105 cancer patients and 288 consultations were matched with the c...
Source: Fundamental and Clinical Pharmacology - October 1, 2017 Category: Drugs & Pharmacology Authors: Luc Cabel, Benoit Blanchet, Audrey Thomas ‐Schoemann, Olivier Huillard, Audrey Bellesoeur, Anatole Cessot, Julie Giroux, Pascaline Boudou‐Rouquette, Romain Coriat, Michel Vidal, Nathaniel E B Saidu, Lisa Golmard, Jérome Alexandre, Francois Goldwasser Tags: Original Article Source Type: research

From medico ‐administrative databases analysis to care trajectories analytics: an example with the French SNDS
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - September 17, 2017 Category: Drugs & Pharmacology Authors: Erwan Drezen, Thomas Guyet, Andr é Happe Tags: Short Communication Source Type: research

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Fundamental&Clinical Pharmacology,Volume 32, Issue 1, Page 81-84, February 2018. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - September 16, 2017 Category: Drugs & Pharmacology Source Type: research

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Fundamental&Clinical Pharmacology,Volume 32, Issue 1, Page 78-80, February 2018. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - September 16, 2017 Category: Drugs & Pharmacology Source Type: research

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Fundamental&Clinical Pharmacology,Volume 32, Issue 1, Page 85-87, February 2018. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - September 16, 2017 Category: Drugs & Pharmacology Source Type: research

Visualization of temporal patterns in patient record data
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - September 16, 2017 Category: Drugs & Pharmacology Authors: Catherine Plaisant Tags: Short Communication Source Type: research

A visual approach of care pathways from the French nationwide SNDS database. From population to individual records: the ePEPS toolbox
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - September 16, 2017 Category: Drugs & Pharmacology Authors: Andr é Happe, Erwan Drezen Tags: Short Communication Source Type: research

Rationale and design of the CANARI study: a case –control study investigating the association between prostate cancer and 5‐alpha‐reductase inhibitors for symptomatic benign prostate hypertrophy by linking SNIIRAM and pathology laboratories in a specific region in France
Abstract Benign prostate hypertrophy (BPH) could be associated with low urinary symptoms requiring medical treatment: 5‐alpha‐reductase inhibitors (5‐ARI) or ɑ‐blockers. Two clinical trials investigating 5‐ARI use in prostate cancer (PCa) primary prevention highlighted a potential safety signal with an increased risk of high‐grade PCa. Later observational studies failed to show similar results but have some limits. This paper focuses on describing the protocol of the CANARI study and its feasibility, as regards the matching process of two pseudo‐anonymous databases. The study concerned patients living in the...
Source: Fundamental and Clinical Pharmacology - September 14, 2017 Category: Drugs & Pharmacology Authors: Lucie ‐Marie Scailteux, Frédéric Balusson, Sébastien Vincendeau, Nathalie Rioux‐Leclercq, Emmanuel Nowak Tags: Original Article Source Type: research

Atropinic (Anticholinergic) Burden in Antipsychotic ‐Treated Patients
This study showed high values of anticholinergic burden in patients receiving antipsychotics. Thus, considering the potential noxious clinical impact of atropinic properties on cognitive functions, an appropriate approach should be to reduce prescription of antipsychotics with a high anticholinergic burden but also coprescription of other frequently associated atropinic drugs, like antiparkinsonians, H1 antihistamines or imipraminic antidepressants in these patients. This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - September 9, 2017 Category: Drugs & Pharmacology Authors: Fran çois Montastruc, Justine Benevent, Anthony Touafchia, Leila Chebane, Mélanie Araujo, Emmanuelle Guitton‐Bondon, Geneviève Durrieu, Christophe Arbus, Laurent Schmitt, Bernard Begaud, Jean‐Louis Montastruc Tags: Original Article Source Type: research

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Fundamental&Clinical Pharmacology,Volume 32, Issue 1, Page 114-119, February 2018. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - September 9, 2017 Category: Drugs & Pharmacology Source Type: research

The impact of age and sex on the reporting of cough and angioedema with renin –angiotensin system inhibitors: a case/noncase study in VigiBase
Abstract The purpose of this study was to assess the impact of age and sex on the reporting of cough and angioedema related to renin–angiotensin system (RAS) inhibitors. A case/noncase study was performed in VigiBase. Two case groups were identified, reports of cough and reports of angioedema, and noncases were all reports of all other adverse events. Logistic regression analysis was used to assess the association between reporting of cough and angioedema with each class of RAS inhibitors stratified by age/sex and to control for confounding. The reporting of cough with angiotensin‐converting enzyme (ACE) inhibitors was...
Source: Fundamental and Clinical Pharmacology - September 5, 2017 Category: Drugs & Pharmacology Authors: Fawaz F. Alharbi, Anzhelika A.V. Kholod, Patrick C. Souverein, Ronald H. Meyboom, Mark C.H. Groot, Anthonius Boer, Olaf H. Klungel Tags: Original Article Source Type: research