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Significance of mitochondria on cardiometabolic syndromes
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 1, 2018 Category: Drugs & Pharmacology Authors: Nair Anupama, G. Sindhu, K G Raghu Tags: Review Article Source Type: research

Infectious risk of biological drugs versus traditional systemic treatments in moderate to severe psoriasis: a cohort analysis in the French insurance database
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 1, 2018 Category: Drugs & Pharmacology Authors: Sylvain Couderc, Maryse Lapeyre ‐Mestre, Robert Bourrel, Paul Carle, Jean‐Louis Montastruc, Agnès Sommet Tags: Original Article Source Type: research

Medical prescriptions falsified by the patients: a twelve ‐year national monitoring to assess prescription drug diversion
This study aimed to characterize diversion of prescription drugs in France through a comparative analysis of falsified prescriptions collected during three periods from 2001 to 2012. The data recorded in a national program which records all falsified prescriptions presented to community pharmacies were studied. Included data regarded: subjects, prescription forms and drugs. Description of the dataset in 3 periods (2001‐2004, 2005‐2008, and 2009‐2012) was completed with clustering analyses to characterize profiles of prescriptions and subjects associated with the most reported drugs. The 4469 falsified prescriptions c...
Source: Fundamental and Clinical Pharmacology - February 1, 2018 Category: Drugs & Pharmacology Authors: Emilie Jouanjus, Gr égory Guernec, Maryse Lapeyre‐Mestre, Tags: Original Article Source Type: research

EDITORIAL that refers to article ‘Treating hepatic encephalopathy in cirrhotic patients admitted to ICU with sodium phenylbutyrate: a preliminary study’
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - February 1, 2018 Category: Drugs & Pharmacology Authors: Paul Carrier, V éronique Loustaud‐Ratti Tags: Editorial Source Type: research

Aging and hypertension decrease endothelial NO ‐related dilating function and gamma‐glutamyl transferase activity but not S‐nitrosoglutathione‐induced aortic vasodilation
Abstract S‐nitrosoglutathione (GSNO), which is involved in the transport and the storage of NO, induces vasorelaxation. It requires gamma‐glutamyl transferase (GGT), an enzyme present on the endothelium, to transfer NO into the cell. We evaluated whether aging and hypertension, which induce NO‐related dilating dysfunction, are associated with decreased vascular GGT activity and modify the vasorelaxant effect of GSNO. Thoracic aortic rings isolated from male spontaneous hypertensive rats (SHR) and Wistar‐Kyoto rats (WKY) aged 20–22 (adult) or 57–60 weeks (mature) were preconstricted with phenylephrine, then sub...
Source: Fundamental and Clinical Pharmacology - February 1, 2018 Category: Drugs & Pharmacology Authors: Caroline Perrin ‐Sarrado, Fatima Dahboul, Pierre Leroy, Isabelle Lartaud Tags: Original Article Source Type: research

Agmatine co ‐treatment attenuates allodynia and structural abnormalities in cisplatin‐induced neuropathy in rats
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 29, 2018 Category: Drugs & Pharmacology Authors: Basak Donertas, Cigdem Cengelli Unel, Sule Aydin, Emel Ulupinar, Orhan Ozatik, Bilgin Kaygisiz, Engin Yildirim, Kevser Erol Tags: Original Article Source Type: research

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Fundamental&Clinical Pharmacology, Ahead of Print. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 29, 2018 Category: Drugs & Pharmacology Source Type: research

The new therapeutic herbal drug HM0601 and its bioactive compound rutin exert potent anti ‐proliferative activities in mast cells
In conclusion, these results indicate that HM0601 can be used as a new therapeutic herbal drug for prevention and therapeutic intervention of allergic inflammatory diseases. This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 25, 2018 Category: Drugs & Pharmacology Authors: Hyun ‐Ja Jeong, Myoung‐Schook Yoou, Na‐Ra Han, Sung Yeoun Hwang, Kyoung Wan Yoon, Hyung‐Min Kim Tags: Original Article Source Type: research

Possible role of CYP2B6 genetic polymorphisms in ifosfamide ‐induced encephalopathy: report of three cases
Fundamental&Clinical Pharmacology, EarlyView. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 25, 2018 Category: Drugs & Pharmacology Source Type: research

Adverse drug reactions of analgesic medicines: analysis of the Romanian pharmacovigilance database
Fundamental&Clinical Pharmacology, EarlyView. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 25, 2018 Category: Drugs & Pharmacology Source Type: research

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Fundamental&Clinical Pharmacology, Ahead of Print. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 25, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effect of fenofibrate against ischemia ‐/reperfusion‐induced cardiac arrhythmias in isolated rat hearts
Abstract Fenofibrate is a peroxisome proliferator‐activated receptor (PPAR)‐α activator that lowers triglycerides and influences cytochrome P‐450 (CYP‐450) epoxygenase‐dependent arachidonic acid (AA) metabolism. CYP‐450 epoxygenase metabolizes AA to epoxyeicosatrienoic acids (EETs). EETs have coronary dilating and cardiac and renal protective properties. Fibrates possess similar properties due to their CYP‐450 epoxygenase‐inducing properties that lead to increase in endogenous EET production. In the current investigations, fenofibrate (100 mg/kg, orally) for 2 weeks decreased ischemia‐/reperfusion (I/R)...
Source: Fundamental and Clinical Pharmacology - January 25, 2018 Category: Drugs & Pharmacology Authors: Ishfaq A. Bukhari, Abdulrahman A. Almotrefi, Osama Y. Mohamed, Abeer A. Al ‐Masri, Saeed A. Sheikh Tags: Original Article Source Type: research

Drug ‐induced aseptic meningitis: a mini‐review
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Source: Fundamental and Clinical Pharmacology - January 24, 2018 Category: Drugs & Pharmacology Authors: Melissa Yelehe ‐Okouma, Julie Czmil‐Garon, Elise Pape, Nadine Petitpain, Pierre Gillet Tags: Review Article Source Type: research