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Inhibition of transient receptor potential vanilloid ‐1 confers neuroprotection, reduces tumor necrosis factor‐alpha, and increases IL‐10 in a rat stroke model
In this study, the effects of TRPV1 agonist (capsaicin) and antagonist (AMG9810) on cerebral ischemia were investigated. Forty male Wistar rats were assigned to the following experimental groups: sham, vehicle) ischemic), AMG9810 (selective TRPV1 antagonist, 0.5 mg/kg; 3 h after stroke), and capsaicin (1 mg/kg; 3 h after stroke). Stroke was induced by permanent middle cerebral artery occlusion and neurological deficits were evaluated 1, 3, and 7 days after stroke. Then, infarct volume, brain edema, body temperature, mRNA expression of TRPV1, and serum concentrations of tumor necrosis factor‐alpha (TNF‐α) and IL‐10 w...
Source: Fundamental and Clinical Pharmacology - March 23, 2017 Category: Drugs & Pharmacology Authors: Elham Hakimizadeh, Ali Shamsizadeh, Ali Roohbakhsh, Mohammad Kazemi Arababadi, Mohammad R. Hajizadeh, Mehdi Shariati, Mohammad R. Rahmani, Mohammad Allahtavakoli Tags: Original Article Source Type: research

Dapsone ‐induced agranulocytosis – possible involvement of low activity N‐acetyltransferase 2
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Source: Fundamental and Clinical Pharmacology - March 21, 2017 Category: Drugs & Pharmacology Authors: Ines Poto čnjak, Robert Likić, Iveta Šimić, Danica Juričić Nahal, Ivana Čegec, Lana Ganoci, Nada Božina Tags: Case Report Source Type: research

Opioid substitution therapy or hidden opioids are a minefield for nalmefene: an atypical case series of 11 patients in Lorraine
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Source: Fundamental and Clinical Pharmacology - March 20, 2017 Category: Drugs & Pharmacology Authors: Melissa Y éléhé‐Okouma, Hervé Martini, Jérémie Lemarié, Pierre Labroca, Nadine Petitpain, Valérie Gibaja, François Paille, Pierre Gillet Tags: Short Communication Source Type: research

Fingolimod (Gilenya ®) in Multiple Sclerosis: bradycardia, atrioventricular blocks and mild effect on the QTc interval. Something to do with the L‐type calcium channel?
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Source: Fundamental and Clinical Pharmacology - March 16, 2017 Category: Drugs & Pharmacology Authors: Sylvie Pilote, Chantale Simard, Benoit Drolet Tags: Original Article Source Type: research

The role of interleukin ‐1b and its antagonist (Diacerein) in Estradiol Benzoate‐induced endometrial hyperplasia and atypia in female rats
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Source: Fundamental and Clinical Pharmacology - March 15, 2017 Category: Drugs & Pharmacology Authors: Marwa M.M. Refaie, Maram El ‐Hussieny Tags: Original Article Source Type: research

Double ‐stranded RNA‐dependent protein kinase signalling and paradigms of cardiometabolic syndrome
Abstract Metabolic syndrome (Met S) is a collection of the most severe cardiometabolic risk factors that encompasses raised fasting plasma glucose, dyslipidaemia, insulin resistance, obesity and hypertension. The precise mechanism underlying the pathogenesis of Met S remains unclear. More often oxidative stress, inflammation and apoptosis are implicated in its aetiology. Recently, double‐stranded RNA‐dependent protein kinase has been found to intersect at the cross‐road of oxidative stress, inflammation and apoptosis in several metabolic diseases. Therefore, an effort has been made in the present review to discuss th...
Source: Fundamental and Clinical Pharmacology - March 12, 2017 Category: Drugs & Pharmacology Authors: Jaspreet Kalra, Arti Dhar Tags: Review Article Source Type: research

Parachlorophenylalanine induced 5 ‐HT depletion alters behavioural and brain neurotransmitters levels in 6 Hertz psychomotor seizure model in mice
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Source: Fundamental and Clinical Pharmacology - March 10, 2017 Category: Drugs & Pharmacology Authors: Kausar Jahan, Krishna K. Pillai, Divya Vohora Tags: Original Article Source Type: research

Issue Information
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Source: Fundamental and Clinical Pharmacology - March 7, 2017 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Enhanced transient receptor potential channel ‐mediated Ca2+ influx in the cells with phospholipase C‐δ1 overexpression: its possible role in coronary artery spasm
We reported that coronary spasm was induced in the transgenic mice with the increased phospholipase C (PLC)‐δ1 activity. We investigated the effect of enhanced PLC‐δ1 on Ca2+ influx and its underlying mechanisms. We used human embryonic kidney (HEK)‐293 and coronary arteries smooth muscle cells (CASMC). Intracellular free Ca2+ concentration ([Ca2+]i; nm) was measured by fura‐2, and Ca2+ influx was evaluated by the increase in [Ca2+]i after addition of extracellular Ca2+. Acetylcholine (ACh) was used to induce Ca2+ influx. ACh‐induced peak Ca2+ influx was 19 ± 3 in control HEK‐293 cells and 71 ± 8 in the cel...
Source: Fundamental and Clinical Pharmacology - February 15, 2017 Category: Drugs & Pharmacology Authors: Kazuo Murakami, Tomohiro Osanai, Makoto Tanaka, Kimitaka Nishizaki, Takahiko Kinjo, Tomohiro Tanno, Yuji Ishida, Akiko Suzuki, Tomohide Endo, Hirofumi Tomita, Ken Okumura Tags: Original Article Source Type: research

Testosterone supplementation, glucocorticoid milieu and bone homeostasis in the ageing male
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Source: Fundamental and Clinical Pharmacology - February 9, 2017 Category: Drugs & Pharmacology Authors: Vladimir Z. Ajd žanović, Branko R. Filipović, Branka T. Šošić Jurjević, Verica Lj. Milošević Tags: Review Article Source Type: research

Can drugs induce or aggravate sleep apneas? A case –noncase study in VigiBase®, the WHO pharmacovigilance database
This study investigates drugs associated with SAS in a pharmacovigilance database. SAS recorded as adverse drug reactions (ADRs) in VigiBase®, the WHO pharmacovigilance database (more than 11 million reports), from 1978 to 2015 was selected. The risk of SAS reports was estimated using the case–noncase method, with cases being SAS and noncases all other recorded ADRs. During this 37‐year period, 3325 ADRs including the word SAS were registered (0.05% of the database). Mean age was 51.2 ± 16.9 years with 52% men. ADRs were ‘serious’ in around 82% of cases. The case–noncase study found an association between SAS a...
Source: Fundamental and Clinical Pharmacology - February 1, 2017 Category: Drugs & Pharmacology Authors: M élanie Linselle, Agnès Sommet, Emmanuelle Bondon‐Guitton, Florence Moulis, Geneviève Durrieu, Justine Benevent, Vanessa Rousseau, Leila Chebane, Haleh Bagheri, François Montastruc, Jean‐Louis Montastruc Tags: Original Article Source Type: research

Effect of bucladesine, Pentoxifylline, and H ‐89 as cyclic adenosine monophosphate analog, phosphodiesterase and protein kinase A inhibitor on acute pain
In conclusion, PTX, H‐89, and Db‐cAMP affect the thermal‐induced pain by probably interacting with intracellular cAMP and cGMP signaling pathways and cyclic nucleotide‐dependent protein kinases. This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 31, 2017 Category: Drugs & Pharmacology Authors: Forouz Salehi, Mahshid Sadat Hosseini ‐Zare, Haleh Aghajani, Yalda Seyedi, Maryam Sadat Hosseini‐Zare, Mohammad Sharifzadeh Tags: Original Article Source Type: research

Effect of dementia on receipt of influenza vaccine: a cohort study in French older adults using administrative data: 2007 ‐2012
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Source: Fundamental and Clinical Pharmacology - January 31, 2017 Category: Drugs & Pharmacology Authors: Adeline Gallini, Nicola Coley, Sandrine Andrieu, Maryse Lapeyre ‐Mestre, Virginie Gardette Tags: Original Article Source Type: research

Anti ‐fatigue effects of troxerutin on exercise endurance capacity, oxidative stress and MMP‐9 levels in trained male rats
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Source: Fundamental and Clinical Pharmacology - January 31, 2017 Category: Drugs & Pharmacology Authors: Mohammad Zamanian, Mohammad R. Hajizadeh, Ali Esmaeili Nadimi, Ali Shamsizadeh, Mohammad Allahtavakoli Tags: Original Article Source Type: research

Inhibition of TRPV1 confers neuroprotection, reduces TNF ‐α and increases Il‐10 in a rat stroke model
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - January 31, 2017 Category: Drugs & Pharmacology Authors: Elham Hakimizadeh, Ali Shamsizadeh, Ali Roohbakhsh, Mohammad Kazemi Arababadi, Mohammad Reza Hajizadeh, Mehdi Shariati, Mohammad Reza Rahmani, Mohammad Allahtavakoli Tags: Original Article Source Type: research