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Branched Chain Amino Acids Supplementation Modulates TGF ‐β1/ Smad Signaling Pathway and Interleukins in CCl4 – Induced Liver Fibrosis
This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - May 23, 2017 Category: Drugs & Pharmacology Authors: Naglaa F. Khedr, Eman G. Khedr Tags: Original Article Source Type: research

Modulation of heme oxygenase ‐1 expression and activity affects streptozotocin‐induced diabetic nephropathy in rats
In conclusion, activation of HO‐1 via HM ameliorated renal damage in STZ‐induced DN in rats, probably through antioxidant, anti‐nitrosative, anti‐inflammatory and anti‐apoptotic mechanisms. This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - May 23, 2017 Category: Drugs & Pharmacology Authors: Marwa A.M. Ali, Gehan H. Heeba, Azza A.K. El ‐Sheikh Tags: Original Article Source Type: research

Issue Information
(Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - May 12, 2017 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Parachlorophenylalanine ‐induced 5‐HT depletion alters behavioral and brain neurotransmitters levels in 6‐Hz psychomotor seizure model in mice
Abstract The present study was designed to investigate the role of serotonin and other neurotransmitters namely dopamine (DA), histamine, nor‐epinephrine (NE), glutamate, and γ‐aminobutyric acid (GABA) in the 6‐Hz‐induced psychomotor seizures in Swiss albino mice. Parachlorophenylalanine (PCPA, 300 mg/kg/day, i.p for 3 days)‐treated mice were given 6‐Hz stimulation. Sodium valproate (SVP) (200 mg/kg/day, p.o for 3 days) was used as a reference antiepileptic drug. The behavioral changes induced by 6 Hz including increased rearing and grooming, Straub's tail, behavioral arrest, stun position were amplified by PC...
Source: Fundamental and Clinical Pharmacology - April 26, 2017 Category: Drugs & Pharmacology Authors: Kausar Jahan, Krishna K. Pillai, Divya Vohora Tags: Original Article Source Type: research

Fingolimod (Gilenya ®) in multiple sclerosis: bradycardia, atrioventricular blocks, and mild effect on the QTc interval. Something to do with the L‐type calcium channel?
This study was aiming to further elucidate the effects of fingolimod on cardiac electrophysiology at three different levels: (i) in vitro, (ii) ex vivo, and (iii) in vivo. (i) Patch‐clamp experiments in whole cell configuration were performed on Cav1.2‐transfected tsA201 cells exposed to fingolimod‐phosphate 100 or 500 nmol/L (n = 27 cells, total) to measure drug effect on L‐type calcium current (ICaL). (ii) Langendorff perfusion experiments were undertaken on male Hartley guinea‐pigs isolated hearts (n = 4) exposed to fingolimod 10 and 100 nmol/L to evaluate drug‐induced effects on monophasic action potential ...
Source: Fundamental and Clinical Pharmacology - April 26, 2017 Category: Drugs & Pharmacology Authors: Sylvie Pilote, Chantale Simard, Benoit Drolet Tags: Original Article Source Type: research

Dapsone ‐induced agranulocytosis—possible involvement of low‐activity N‐acetyltransferase 2
Abstract Dapsone‐induced agranulocytosis is a rare but potentially fatal adverse drug reaction (ADR). A 45‐year‐old male Caucasian patient developed agranulocytosis caused by dapsone (diamino‐diphenyl sulfone), which he was prescribed for leukocytoclastic vasculitis. Patient's treatment consisted of termination of dapsone, antibiotic therapy, and granulocyte colony‐stimulating factor leading to prompt improvement of symptoms and normalization of laboratory blood values. Diagnostic evaluation revealed methemoglobinemia and excluded glucose‐6‐phosphate dehydrogenase deficiency. Pharmacogenetics testing showed t...
Source: Fundamental and Clinical Pharmacology - April 26, 2017 Category: Drugs & Pharmacology Authors: Ines Poto čnjak, Robert Likić, Iveta Šimić, Danica Juričić Nahal, Ivana Čegec, Lana Ganoci, Nada Božina Tags: Case Report Source Type: research

Rifampicin reverses nicardipine effect inducing uncontrolled essential hypertension
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Source: Fundamental and Clinical Pharmacology - April 13, 2017 Category: Drugs & Pharmacology Authors: Elena ‐Mihaela Cordeanu, Sébastien Gaertner, Alix Faller, Corina Mirea, Jean‐Marc Lessinger, Veronique Kemmel, Dominique Stephan Tags: Case Report Source Type: research

Phenobarbital in intensive care unit pediatric population: Predictive performances of population pharmacokinetic model
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Source: Fundamental and Clinical Pharmacology - April 13, 2017 Category: Drugs & Pharmacology Authors: Am élie Marsot, Fabrice Michel, Estelle Chasseloup, Olivier Paut, Romain Guilhaumou, Olivier Blin Tags: Original Article Source Type: research

Antifatigue effects of troxerutin on exercise endurance capacity, oxidative stress and matrix metalloproteinase ‐9 levels in trained male rats
Abstract The aim of this study was to investigate effects of troxerutin (TRX) on endurance capacity, oxidative stress and matrix metalloproteinase‐9 (MMP‐9) levels in trained male rats. Forty male Wistar rats were divided into five groups. The control (Vehicle) and exercise training (5 days/week) with vehicle treatment (Exercise), exercise training with TRX treatment at 75 (Ex‐TRX75), 150 (Ex‐TRX150), and 300 mg/kg (Ex‐TRX300). The treated groups received TRX by gavage every day while the other groups received water for 30 days. On the 30th day, rats were sacrificed immediately after exhaustive swimming test, ...
Source: Fundamental and Clinical Pharmacology - April 4, 2017 Category: Drugs & Pharmacology Authors: Mohammad Zamanian, Mohammad R. Hajizadeh, Ali Esmaeili Nadimi, Ali Shamsizadeh, Mohammad Allahtavakoli Tags: Original Article Source Type: research

Epigallocatechin 3 ‐gallate ameliorates intrahepatic cholestasis of pregnancy by inhibiting matrix metalloproteinases‐2 and 9
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Source: Fundamental and Clinical Pharmacology - April 1, 2017 Category: Drugs & Pharmacology Authors: Mei Zhang, Meimei Xu Tags: Original Article Source Type: research

Effect of alpha ‐lipoic acid on endometrial implants in an experimental rat model
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Source: Fundamental and Clinical Pharmacology - April 1, 2017 Category: Drugs & Pharmacology Authors: Neslihan P ınar, Oya Soylu Karapınar, Oğuzhan Özcan, Tümay Özgür, Suphi Bayraktar Tags: Original Article Source Type: research

Finding the optimal dose of vitamin K1 to treat vitamin K deficiency and to avoid anaphylactoid reactions
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Source: Fundamental and Clinical Pharmacology - April 1, 2017 Category: Drugs & Pharmacology Authors: Yan ‐ni Mi, Na‐na Ping, Bo Li, Xue Xiao, Yan‐bing Zhu, Lei Cao, Jian‐kang Ren, Yong‐xiao Cao Tags: Original Article Source Type: research

Zizyphin modulates calcium signalling in human taste bud cells and fat taste perception in the mouse
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Source: Fundamental and Clinical Pharmacology - April 1, 2017 Category: Drugs & Pharmacology Authors: Babar Murtaza, Meryem Berrichi, Chahid Bennamar, Thierry Tordjmann, Fatima Zohara Djeziri, Aziz Hichami, Julia Leemput, Meriem Belarbi, Hakan Ozdener, Naim A. Khan Tags: Original Article Source Type: research

Curcuma decreases serum hepcidin levels in healthy volunteers: a placebo ‐controlled, randomized, double‐blind, cross‐over study
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Source: Fundamental and Clinical Pharmacology - March 30, 2017 Category: Drugs & Pharmacology Authors: Fabrice Lain é, Bruno Laviolle, Edouard Bardou‐Jacquet, Nadia Fatih, Caroline Jezequel, Nicolas Collet, Martine Ropert, Jeff Morcet, Catherine Hamon, Jean‐Michel Reymann, Olivier Loréal Tags: Original Article Source Type: research

Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta ‐analysis: GLUCOSE DINET protocol—Rational and design
Abstract The aim of this study was to propose a ranking of the currently available antidiabetic drugs, regarding vascular clinical outcomes, in patients with type 2 diabetes, through a network meta‐analysis approach. Randomized clinical trials, regardless of the blinding design, testing contemporary antidiabetic drugs, and considering clinically relevant outcomes in patients with type 2 diabetes mellitus will be included. The primary outcomes of this analysis will be overall mortality, cardiovascular mortality, and major cardiovascular events. Diabetic microangiopathy will be a secondary outcome. Adverse events, hypoglyc...
Source: Fundamental and Clinical Pharmacology - March 23, 2017 Category: Drugs & Pharmacology Authors: Guillaume Grenet, Audrey Lajoinie, Shams Ribault, Gia Bao Nguyen, Thomas Linet, Augustin Metge, Catherine Cornu, Michel Cucherat, Philippe Moulin, Fran çois Gueyffier Tags: Review Article Source Type: research