Imoxin attenuates high fructose induced oxidative stress and apoptosis in renal epithelial cell via downregulation of PKR Pathway

In conclusion our study demonstrates PKR induces oxidative stress and apoptosis, a significant contributor involved in vascular complications and a possible mediator of HF induced hypertension. Inhibition of PKR pathway can be used as a therapeutic strategy for the treatment of cardiovascular and metabolic disorders. This article is protected by copyright. All rights reserved.
Source: Fundamental and Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Original Article Source Type: research