Imoxin attenuates high fructose induced oxidative stress and apoptosis in renal epithelial cell via downregulation of PKR Pathway
In conclusion our study demonstrates PKR induces oxidative stress and apoptosis, a significant contributor involved in vascular complications and a possible mediator of HF induced hypertension. Inhibition of PKR pathway can be used as a therapeutic strategy for the treatment of cardiovascular and metabolic disorders.
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Source: Fundamental and Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Jaspreet Kalra, Suresh Babu Mangali, Audesh Bhat, Indu Dhar, Mary Priyanka Udumula, Arti Dhar Tags: Original Article Source Type: research
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