Environmental and Molecular Mutagenesis 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Occupational exposure to diesel engine exhaust and serum cytokine levels
The International Agency for Research on Cancer has classified diesel engine exhaust (DEE) as a human lung carcinogen. Given that inflammation is suspected to be an important underlying mechanism of lung carcinogenesis, we evaluated the relationship between DEE exposure and the inflammatory response using data from a cross‐sectional molecular epidemiology study of 41 diesel engine testing workers and 46 unexposed controls. Repeated personal exposure measurements of PM2.5 and other DEE constituents were taken for the diesel engine testing workers before blood collection. Serum levels of six inflammatory biomarkers includi...
Source: Environmental and Molecular Mutagenesis - October 12, 2017 Category: Molecular Biology Authors: Yufei Dai, Dianzhi Ren, Bryan A. Bassig, Roel Vermeulen, Wei Hu, Yong Niu, Huawei Duan, Meng Ye, Tao Meng, Jun Xu, Ping Bin, Meili Shen, Jufang Yang, Wei Fu, Kees Meliefste, Debra Silverman, Nathaniel Rothman, Qing Lan, Yuxin Zheng Tags: Research Article Source Type: research
DNA damage and circulating cell free DNA in greenhouse workers exposed to pesticides
Pesticides widely used in agriculture and other applications have been linked to cancer and other diseases through several potential mechanisms. The goals of this study were to assess DNA damage in lymphocytes by the cytokinesis‐block micronucleus assay (CBMN), and to measure circulating cell free DNA (ccf‐DNA) in the blood of pesticide‐exposed greenhouse workers and matched controls living in the same area. CBMN was applied to peripheral blood lymphocyte samples taken at different times (spring and autumn) for each individual. We measured plasma ccf‐DNA levels using a Qubit® fluorometer. The results indicated tha...
Source: Environmental and Molecular Mutagenesis - October 1, 2017 Category: Molecular Biology Authors: Akin Çayir, Mahmut Coskun, Munevver Coskun, Hayal Cobanoglu Tags: Research Article Source Type: research
Prenatal diethylstilbestrol exposure and cancer risk in women
This article is a US Government work and is in the public domain in the USA. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 1, 2017 Category: Molecular Biology Authors: Rebecca Troisi, Elizabeth E. Hatch, Linda Titus, William Strohsnitter, Mitchell H. Gail, Dezheng Huo, Ervin Adam, Stanley J. Robboy, Marianne Hyer, Robert N. Hoover, Julie R. Palmer Tags: Research Article Source Type: research
Quantitative differentiation of whole smoke solution ‐induced mutagenicity in the mouse lymphoma assay
This article is a US Government work and is in the public domain in the USA. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 1, 2017 Category: Molecular Biology Authors: Xiaoqing Guo, Robert H. Heflich, Stacey L. Dial, Mamata De, Patricia A. Richter, Nan Mei Tags: Research Article Source Type: research
Oxidative stress and inflammation mediate the effect of air pollution on cardio ‐ and cerebrovascular disease: A prospective study in nonsmokers
This study aims to investigate the involvement of oxidative stress and inflammation in the causal chain, and to identify intermediate biomarkers that are associated retrospectively with the exposure and prospectively with the disease. We designed a case‐control study on CCVD nested in a cohort of 18,982 individuals from the EPIC‐Italy study. We measured air pollution, inflammatory biomarkers, and whole‐genome DNA methylation in blood collected up to 17 years before the diagnosis. The study sample includes all the incident CCVD cases among former‐ and never‐smokers, with available stored blood sample, that arose i...
Source: Environmental and Molecular Mutagenesis - October 1, 2017 Category: Molecular Biology Authors: Giovanni Fiorito, Jelle Vlaanderen, Silvia Polidoro, John Gulliver, Claudia Galassi, Andrea Ranzi, Vittorio Krogh, Sara Grioni, Claudia Agnoli, Carlotta Sacerdote, Salvatore Panico, Ming ‐Yi Tsai, Nicole Probst‐Hensch, Gerard Hoek, Zdenko Herceg, Roel Tags: Research Article Source Type: research
Establishing a novel Pig ‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
This article is a US Government work and is in the public domain in the USA. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 1, 2017 Category: Molecular Biology Authors: Yiying Wang, Javier Revollo, Page McKinzie, Mason G. Pearce, Azra Dad, Berran Yucesoy, Hans Rosenfeldt, Robert H. Heflich, Vasily N. Dobrovolsky Tags: Research Article Source Type: research
Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta ‐analysis
Candidate gene as well as genome‐wide association studies identified several polymorphic variants to be associated with lung cancer worldwide including in India. However, contradictory results have failed to estimate the overall effect of the polymorphic variants on the disease. Textmining was conducted on PubMed following specific search strings to gather all the publications related to genetic association with lung cancer in India. Out of 211 PubMed hits only 30 studies were selected for meta‐analysis following specific inclusion criteria. Heterogeneity between studies was calculated by Cochran's Q‐test (P <...
Source: Environmental and Molecular Mutagenesis - October 1, 2017 Category: Molecular Biology Authors: Debmalya Sengupta, Udayan Guha, Samsiddhi Bhattacharjee, Mainak Sengupta Tags: Research Article Source Type: research
Comments on “Sesamol ameliorates radiation induced DNA damage in hematopoietic system of whole body γ‐irradiated mice”
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 1, 2017 Category: Molecular Biology Authors: S. M. J. Mortazavi Tags: Letter to the Editor Source Type: research
Comparing BMD ‐derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay
This study therefore employed the BMD approach to examine the ability of different TGR variants to yield comparable genotoxic potency estimates. Review of over 2000 dose‐response datasets identified suitably‐matched dose‐response data for three compounds (ethyl methanesulfonate or EMS, N‐ethyl‐N‐nitrosourea or ENU, and dimethylnitrosamine or DMN) across four commonly‐used murine TGR variants (Muta™Mouse lacZ, Muta™Mouse cII, gpt delta and BigBlue® lacI). Dose‐response analyses provided no conclusive evidence that TGR variant choice significantly influences the derived genotoxic potency estimate. This c...
Source: Environmental and Molecular Mutagenesis - September 25, 2017 Category: Molecular Biology Authors: John W. Wills, George E. Johnson, Hannah L. Battaion, Wout Slob, Paul A. White Tags: Research Article Source Type: research
Association of with ‐no‐lysine kinase 1 and Serine/Threonine kinase 39 gene polymorphisms and haplotypes with essential hypertension in Tibetans
In conclusion, SNP rs1468326 of WNK1, rs6749447 of STK39, and WNK1 haplotype AGACAGGAATCGT were associated with hypertension in Tibetan individuals. Environ. Mol. Mutagen., 2017. © 2017 Wiley Periodicals, Inc. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - September 25, 2017 Category: Molecular Biology Authors: Rufeng Shi, Jiangbo Li, Jiyun He, Qingtao Meng, Zhiping Qian, Di Shi, Qi Liu, Yali Cai, Xinran Li, Xiaoping Chen Tags: Research Article Source Type: research
Do mutations in DNMT3A/3B affect global DNA hypomethylation among benzene ‐exposed workers in Southeast China?: Effects of mutations in DNMT3A/3B on global DNA hypomethylation
Global DNA hypomethylation is commonly observed in benzene‐exposed workers, but the underlying mechanisms remain unclear. We sought to discover the relationships among reduced white blood cell (WBC) counts, micronuclear (MN) frequency, and global DNA methylation to determine whether there were associations with mutations in DNMT3A/3B. Therefore, we recruited 410 shoe factory workers and 102 controls from Wenzhou in Zhenjiang Province. A Methylated DNA Quantification Kit was used to quantify global DNA methylation, and single nucleotide polymorphisms (SNPs) in DNMT3A (rs36012910, rs1550117, and R882) and DNMT3B (rs1569686...
Source: Environmental and Molecular Mutagenesis - September 25, 2017 Category: Molecular Biology Authors: Guang ‐hui Zhang, Ye Lu, Bu‐qiang Ji, Jing‐chao Ren, Pin Sun, Shibin Ding, Xiaoling Liao, Kaiju Liao, Jinyi Liu, Jia cao, Qing Lan, Nathaniel Rothman, Zhao‐lin Xia Tags: Research Article Source Type: research
Health survey and assessment of the polymorphisms BRCA1/P871L, BRCA1/Q356R, and BRCA2/N372H in female gas station workers in Rio de Janeiro
The objective was to analyze the health problems of female gas station workers by means of sociodemographic and clinical questionnaires, and laboratorial exams. We performed the genotyping of the polymorphisms BRCA1/P871L and BRCA1/Q356R by Polymerase Chain Reaction‐Restriction Fragment Length Polymorphism, and of variant allele BRCA2/N372H through direct sequencing. The female workers showed a higher concentration of monocytes (P = 0.039); a greater number of spontaneous abortions (P = 0.025, OR = 4.977, 95% CI = 1.135–30.669); higher tobacco consumption (P = 0.013); and higher alcohol consumption ...
Source: Environmental and Molecular Mutagenesis - September 1, 2017 Category: Molecular Biology Authors: Rafaele T. Silvestre, Lucas Delmonico, Maryah Bravo, F ábio Santiago, Luciano R. Scherrer, Aline dos Santos Moreira, Marianne Tabalipa, Ubirani Otero, Maria Helena F. Ornellas, Gilda Alves Tags: Brief Communication Source Type: research
Performance of the in vitro transgene mutation assay in MutaMouse FE1 cells: Evaluation of nine misleading ( “False”) positive chemicals
In this study, the performance of the FE1 cell assay was evaluated by examining responses to nine non‐DNA‐reactive chemicals that previously elicited misleading positive results in other mammalian cell genotoxicity assays. FE1 cells were exposed to concentrations up to approximately 10 mM and/or concentrations that yielded approximately 80‐90% cytotoxicity (as measured by relative increase in cell count). The assay demonstrated excellent specificity; exposures to the chemicals examined did not yield any positive responses even when tested in the presence of an exogenous metabolic activation system (i.e. S9) or with a...
Source: Environmental and Molecular Mutagenesis - August 26, 2017 Category: Molecular Biology Authors: Rebecca M. Maertens, Alexandra S. Long, Paul A. White Tags: Research Article Source Type: research
Telomerase activity, telomere length and hTERT DNA methylation in peripheral blood mononuclear cells from monozygotic twins with discordant smoking habits
In conclusion, these results indicate an association of tobacco smoke with TA and TL and suggest a possible association between smoke‐induced epigenetic effects and TA in healthy smokers. Environ. Mol. Mutagen., 2017. © 2017 Wiley Periodicals, Inc. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - August 26, 2017 Category: Molecular Biology Authors: Francesca Marcon, Ester Siniscalchi, Cristina Andreoli, Alessandra Allione, Giovanni Fiorito, Emanuela Medda, Simonetta Guarrera, Giuseppe Matullo, Riccardo Crebelli Tags: Research Article Source Type: research
Single nucleotide polymorphisms rs911160 in AURKA and rs2289590 in AURKB mitotic checkpoint genes contribute to gastric cancer susceptibility
Conclusion: Our findings suggested that AURKA (rs911160) and AURKB (rs2289590) polymorphisms could affect GC risk. Further validation studies in larger and multi‐ethnical populations are needed to elucidate their functional impact on the development of GC. Environ. Mol. Mutagen., 2017. © 2017 Wiley Periodicals, Inc. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - August 26, 2017 Category: Molecular Biology Authors: Aner Mesic, Ela Markocic, Marija Rogar, Robert Juvan, Petra Hudler, Radovan Komel Tags: Research Article Source Type: research
