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Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 260-262, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - December 29, 2017 Category: Molecular Biology Source Type: research

Genotoxicity associated with the use of tyrosine kinase inhibitors in patients with chronic myeloid leukemia
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - December 29, 2017 Category: Molecular Biology Authors: Pedro Aurio Maia Filho, Tarc ísio Paulo de Almeida Filho, Caroline de Fátima Aquino Moreina‐Nunes, Rommel Rodriguez Burbano, José Alexandre Rodrigues de Lemos, Edivaldo Herculano Correa de Oliveira, Bruno Coêlho Cavalcanti, Jamilly Florêncio Pereir Tags: Letter to the Editor Source Type: research

Genotoxic and mutagenic properties of Ni and NiO nanoparticles investigated by comet assay, γ‐H2AX staining, Hprt mutation assay and ToxTracker reporter cell lines
Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 211-222, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - December 15, 2017 Category: Molecular Biology Source Type: research

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Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 211-222, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - December 15, 2017 Category: Molecular Biology Source Type: research

Risk of cancer in children exposed to antiretroviral nucleoside analogues in utero: The french experience
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - December 5, 2017 Category: Molecular Biology Source Type: research

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Environmental and Molecular Mutagenesis, Ahead of Print. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - December 5, 2017 Category: Molecular Biology Source Type: research

A tripartite mode of action approach for investigating the impact of aneugens on tubulin polymerization
Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 188-201, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - December 4, 2017 Category: Molecular Biology Source Type: research

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Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 188-201, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - December 4, 2017 Category: Molecular Biology Source Type: research

Mitochondrial DNA, nuclear context, and the risk for carcinogenesis
The inheritance of mitochondrial DNA (mtDNA) from mother to child is complicated by differences in the stability of the mitochondrial genome. Although the germ line mtDNA is protected through the minimization of replication between generations, sequence variation can occur either through mutation or due to changes in the ratio between distinct genomes that are present in the mother (known as heteroplasmy). Thus, the unpredictability in transgenerational inheritance of mtDNA may cause the emergence of pathogenic mitochondrial and cellular phenotypes in offspring. Studies of the role of mitochondrial metabolism in cancer hav...
Source: Environmental and Molecular Mutagenesis - December 1, 2017 Category: Molecular Biology Authors: Brett A. Kaufman, Martin Picard, Neal Sondheimer Tags: Review Source Type: research

Sodium fluoride disturbs DNA methylation of NNAT and declines oocyte quality by impairing glucose transport in porcine oocytes
Sodium fluoride (NaF) is used as a medicine to prevent tooth decay; however, excessive NaF could cause a pathological damage to the health. Recent studies showed that NaF impaired mouse oocyte maturation, included of abnormal spindle configuration, actin cap formation, cortical granule‐free domain formation, and the following development after fertilization. However, few studies used large animals as models to study the toxicology of NaF on oocytes maturation. We proposed a hypothesis that NaF would affect the nuclear and cytoplasmic maturation of porcine oocytes and DNA methylation pattern of imprinted genes in oocytes....
Source: Environmental and Molecular Mutagenesis - December 1, 2017 Category: Molecular Biology Authors: Xiaoyan Liu, Zheng ‐Wen Nie, Ying‐Ying Gao, Li Chen, Shu‐Yuan Yin, Xia Zhang, Cuifang Hao, Yi‐Liang Miao Tags: Research Article Source Type: research

Genotoxic and mutagenic properties of Ni and NiO nanoparticles investigated by comet assay, γ‐H2AX staining, Hprt mutation assay and ToxTracker reporter cell lines
Nickel (Ni) compounds are classified as carcinogenic to humans but the underlying mechanisms are still poorly understood. Furthermore, effects related to nanoparticles (NPs) of Ni have not been fully elucidated. The aim of this study was to investigate genotoxicity and mutagenicity of Ni and NiO NPs and compare the effect to soluble Ni from NiCl2. We employed different models; i.e., exposure of (1) human bronchial epithelial cells (HBEC) followed by DNA strand break analysis (comet assay and γ‐H2AX staining); (2) six different mouse embryonic stem (mES) reporter cell lines (ToxTracker) that are constructed to exhibit fl...
Source: Environmental and Molecular Mutagenesis - December 1, 2017 Category: Molecular Biology Authors: Emma Åkerlund, Francesca Cappellini, Sebastiano Di Bucchianico, Shafiqul Islam, Sara Skoglund, Remco Derr, Inger Odnevall Wallinder, Giel Hendriks, Hanna L. Karlsson Tags: Research Article Source Type: research

Risk of cancer in children exposed to antiretroviral nucleoside analogues in utero: The french experience
All nucleoside analogues for treating HIV infection, due to their capacity to integrate into and alter human DNA, are experimentally genotoxic to some extent. The long‐term oncogenic risk after in utero exposure remains to be determined. Cancer incidence in uninfected children exposed to nucleos(t)ide reverse transcriptase inhibitors (NRTIs) was evaluated, by cross‐checking against the National Cancer Registry, in the French perinatal study of children born to HIV+ mothers. Twenty‐one cancers were identified in 15,163 children (median age: 9.9 years [interquartile range (IQR): 5.8–14.2]) exposed to at least one NRT...
Source: Environmental and Molecular Mutagenesis - December 1, 2017 Category: Molecular Biology Authors: Mira Hleyhel, St éphanie Goujon, Jeanne Sibiude, Roland Tubiana, Catherine Dollfus, Albert Faye, Laurent Mandelbrot, Jacqueline Clavel, Josiane Warszawski, Stéphane Blanche, Tags: Research Article Source Type: research

A functional SNP in the 3 ′‐UTR of TAP2 gene interacts with microRNA hsa‐miR‐1270 to suppress the gene expression
In this study, we investigated whether the expression of TAP2 can be perturbed by single nucleotide polymorphisms (SNPs) located in 3′‐untranslated region (3′‐UTR) of the gene via interactions with microRNAs. Using a series of in silico assays, we selected the candidate microRNAs (miRNAs) with the potential to interact with functional SNPs of TAP2. The SNP rs241456—located in the 3′‐UTR of TAP2—resides in a potential binding site for hsa‐miR‐1270 and hsa‐miR‐620. HEK 293 cells, from a human kidney cell line, were used to characterize the extent of binding of miRNAs to each polymorphic allele of the ...
Source: Environmental and Molecular Mutagenesis - December 1, 2017 Category: Molecular Biology Authors: Bridgett Knox, Yong Wang, Lora J. Rogers, Jiekun Xuan, Dianke Yu, Huaijin Guan, Jiwei Chen, Tieliu Shi, Baitang Ning, Susan A. Kadlubar Tags: Research Article Source Type: research

A tripartite mode of action approach for investigating the impact of aneugens on tubulin polymerization
Chemical‐induced disruption of the cellular microtubule network is one key mechanism of aneugenicity. Since recent data indicate that genotoxic effects of aneugens show nonlinear dose‐response relationships, margins of safety can be derived with the ultimate goal to perform a risk assessment for the support of drug development. Furthermore, microtubule‐interacting compounds are widely used for cancer treatment. While there is a need to support the risk assessment of tubulin‐interacting chemicals using reliable mechanistic assays, no standard assays exist to date in regulatory genotoxicity testing for the distinctio...
Source: Environmental and Molecular Mutagenesis - December 1, 2017 Category: Molecular Biology Authors: Valerie Stock, Andreas Sutter, Marian Raschke, Nina Queisser Tags: Research Article Source Type: research

Structure –activity investigation of the potentiating effect of cyano substitution on nitroaniline mutagenicity in the ames test
2,6‐Dicyano‐4‐nitroaniline and 2‐cyano‐4‐nitroaniline (CNNA; 2‐amino‐5‐nitrobenzonitrile) are potent mutagens in the Ames test, even though unsubstituted nitroanilines (NAs) are no more than weak mutagens. These compounds are putative reduction products of many commercial azo dyes, including Disperse Blue 165, Disperse Blue 337, Disperse Red 73, Disperse Red 82, Disperse Violet 33, and Disperse Violet 63. We have examined the mutagenicity in strains TA98 and YG1024 of a series of commercially‐available isomers of CNNA, and some related compounds, to probe the relationship between structure and genotoxic...
Source: Environmental and Molecular Mutagenesis - November 27, 2017 Category: Molecular Biology Authors: P. David Josephy, Joban Dhanoa, George Elzawy, Kayla Heney, Laurenne Petrie, Chantel Senis Tags: Research Article Source Type: research