Environmental and Molecular Mutagenesis 
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Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 176-187, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - January 22, 2018 Category: Molecular Biology Source Type: research
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Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 176-187, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - January 22, 2018 Category: Molecular Biology Source Type: research
Issue Information
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - January 16, 2018 Category: Molecular Biology Tags: Issue Information Source Type: research
Mitochondrial DNA, nuclear context, and the risk for carcinogenesis
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - January 14, 2018 Category: Molecular Biology Source Type: research
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Environmental and Molecular Mutagenesis, Ahead of Print. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - January 14, 2018 Category: Molecular Biology Source Type: research
Corrigendum to “the role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review”
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - January 1, 2018 Category: Molecular Biology Authors: Ali Kermanizadeh, Caroline Chauch é, David M. Brown, Steffen Loft, Peter Møller Tags: Letter to the Editor Source Type: research
High throughput image cytometry micronucleus assay to investigate the presence or absence of mutagenic effects of cold physical plasma
Promising cold physical plasma sources have been developed in the field of plasma medicine. An important prerequisite to their clinical use is lack of genotoxic effects in cells. During optimization of one or even different plasma sources for a specific application, large numbers of samples need to be analyzed. There are soft and easy‐to‐assess markers for genotoxic stress such as phosphorylation of histone H2AX (γH2AX) but only few tests are accredited by the OECD with regard to mutagenicity detection. The micronucleus (MN) assay is among them but often requires manual counting of many thousands of cells per sample u...
Source: Environmental and Molecular Mutagenesis - January 1, 2018 Category: Molecular Biology Authors: Sander Bekeschus, Anke Schmidt, Axel Kramer, Hans ‐Robert Metelmann, Frank Adler, Thomas von Woedtke, Felix Niessner, Klaus‐Dieter Weltmann, Kristian Wende Tags: Research Article Source Type: research
DNA damage ‐induced apoptosis and mitogen‐activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells
In this study, the possible mechanisms of dronedarone induced liver toxicity were characterized in HepG2 cells. Dronedarone decreased cells viability and induced apoptosis and DNA damage in a concentration‐ and time‐dependent manner. Pretreatment of the HepG2 cells with apoptosis inhibitors (caspase‐3, ‐8, and ‐9) or the necrosis inhibitor (Necrox‐5), partially, but significantly, reduced the release of lactate dehydrogenase. Dronedarone caused the release of cytochrome c from mitochondria to cytosol, a prominent feature of apoptosis. In addition, the activation of caspase‐2 was involved in dronedarone induce...
Source: Environmental and Molecular Mutagenesis - January 1, 2018 Category: Molecular Biology Authors: Si Chen, Zhen Ren, Dianke Yu, Baitang Ning, Lei Guo Tags: Research Article Source Type: research
Response to letter to the editor
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - January 1, 2018 Category: Molecular Biology Authors: N. K. Chaudhury Tags: Letter to the editor Source Type: research
Genotoxicity of fine and coarse fraction ambient particulate matter in immortalised normal (TT1) and cancer ‐derived (A549) alveolar epithelial cells
Human exposure to airborne particulate matter (PM) is associated with adverse cardiopulmonary health effects, including lung cancer. Ambient PM represents a heterogeneous mixture of chemical classes including transition metals, polycyclic aromatic hydrocarbons (PAHs) and their derivatives such as nitro‐PAHs, many of which are classified as putative carcinogens. As the primary site of human exposure to PM is the lungs, we investigated the response of two alveolar epithelial cell lines, the tumour‐derived A549 and newly described TT1 cells, to fine and coarse PM collected from background and roadside locations. We show t...
Source: Environmental and Molecular Mutagenesis - January 1, 2018 Category: Molecular Biology Authors: Ian W.H. Jarvis, Zachary Enlo ‐Scott, Eszter Nagy, Ian S. Mudway, Teresa D. Tetley, Volker M. Arlt, David H. Phillips Tags: Research Article Source Type: research
Influence of Carnicor, Venofer, and Sevelamer on the levels of genotoxic damage in end ‐stage renal disease patients
End‐stage renal disease (ESRD) patients present high levels of phosphorus and calcium products in serum, which contribute to the development of vascular calcification and cardiovascular disease, and to low iron stores and carnitine deficiency. For these reasons, ESRD patients are generally supplemented with different medicines. Some of the most common treatments include the use of Carnicor, Venofer, and Sevelamer drugs. Carnicor is used as a source of L‐carnitine, acting as antioxidant and neuroprotector. Venofer is used to reduce the deficit of iron. Sevelamer is used to treat hyperphosphatemia. To determine the poten...
Source: Environmental and Molecular Mutagenesis - January 1, 2018 Category: Molecular Biology Authors: Susana Pastor, Elisabeth Coll, Lara Rodr íguez‐Ribera, Elitsa Stoyanova, Zuray F. Corredor, Ricard Marcos Tags: Research Article Source Type: research
Flow cytometric method for scoring rat liver micronuclei with simultaneous assessments of hepatocyte proliferation
The current report describes a newly devised method for automatically scoring the incidence of rat hepatocyte micronuclei (MNHEP) via flow cytometry, with concurrent assessments of hepatocyte proliferation—frequency of Ki‐67‐positive nuclei, and the proportion of polyploid nuclei. Proof‐of‐concept data are provided from experiments performed with 6‐week old male Crl:CD(SD) rats exposed to diethylnitrosamine (DEN) or quinoline (QUIN) for 3 or 14 consecutive days. Non‐perfused liver tissue was collected 4 days after cessation of treatment in the case of 3‐day studies, or 1 day after last administration in the...
Source: Environmental and Molecular Mutagenesis - January 1, 2018 Category: Molecular Biology Authors: Svetlana L. Avlasevich, Sumee Khanal, Priyanka Singh, Dorothea K. Torous, Jeffrey C. Bemis, Stephen D. Dertinger Tags: Research Article Source Type: research
Sodium fluoride disturbs DNA methylation of NNAT and declines oocyte quality by impairing glucose transport in porcine oocytes
Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 223-233, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - December 29, 2017 Category: Molecular Biology Source Type: research
Genotoxicity associated with the use of tyrosine kinase inhibitors in patients with chronic myeloid leukemia
Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 260-262, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - December 29, 2017 Category: Molecular Biology Source Type: research
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Environmental and Molecular Mutagenesis,Volume 59, Issue 3, Page 223-233, April 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - December 29, 2017 Category: Molecular Biology Source Type: research
