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(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - July 31, 2016 Category: Molecular Biology Tags: Cover Image Source Type: research

Issue Information
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - July 13, 2016 Category: Molecular Biology Tags: Issue Information Source Type: research

Cover Image
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - July 13, 2016 Category: Molecular Biology Tags: Cover Image Source Type: research

Oral exposure to commercially available coal tar ‐based pavement sealcoat induces murine genetic damage and mutations
In this study we examined the genotoxicity of an extract of a commercially available CT‐based sealcoat in the transgenic Muta™Mouse model. Mice were orally exposed to 3 doses of sealcoat extract daily for 28 days. We evaluated genotoxicity by examining: (1) stable DNA adducts and (2) lacZ mutations in bone marrow, liver, lung, small intestine, and glandular stomach, as well as (3) micronucleated red blood cells. Significant increases were seen for each endpoint and in all tissues. The potency of the response differed across tissues, with the highest frequency of adducts occurring in liver and lung, and the highest fre...
Source: Environmental and Molecular Mutagenesis - June 30, 2016 Category: Molecular Biology Authors: Alexandra S. Long, Margaret Watson, Volker M. Arlt, Paul A. White Tags: Research Article Source Type: research

Mitochondrial compromise in 3 ‐year old patas monkeys exposed in utero to human‐equivalent antiretroviral therapies
Antiretroviral (ARV) drug therapy, given during pregnancy for prevention of mother‐to‐child transmission of human immunodeficiency virus 1 (HIV‐1), induces fetal mitochondrial dysfunction in some children. However, the persistence/reversibility of that dysfunction is unclear. Here we have followed Erythrocebus patas (patas) monkey offspring for up to 3 years of age (similar in development to a 15‐year old human) after exposure of the dams to human‐equivalent in utero ARV exposure protocols. Pregnant patas dams (3–5/exposure group) were given ARV drug combinations that included zidovudine (AZT)/lamivudine (3TC)...
Source: Environmental and Molecular Mutagenesis - June 30, 2016 Category: Molecular Biology Authors: Yongmin Liu, Eunwoo Shim Park, Alexander T. Gibbons, Eric D. Shide, Rao L. Divi, Ruth A. Woodward, Miriam C. Poirier Tags: Research Article Source Type: research

The rs6983267 SNP and long non ‐coding RNA CARLo‐5 are associated with endometrial carcinoma
In conclusion, CARLo‐5 was identified as a pro‐oncogenic lncRNA that may play an important role in EC progression and represent a prognostic marker for EC. The expression of CARLo‐5 was significantly correlated with the rs6983267 genotype associated with increased susceptibility to EC. Environ. Mol. Mutagen., 2016. © 2016 Wiley Periodicals, Inc. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - June 30, 2016 Category: Molecular Biology Authors: Xiwa Zhao, Xurui Wei, Lianmei Zhao, Li Shi, Jianxin Cheng, Shan Kang, Hui Zhang, Jun Zhang, Li Li, Haibo Zhang, Wei Zhao Tags: Research Article Source Type: research

The rs6983267 SNP and long non‐coding RNA CARLo‐5 are associated with endometrial carcinoma
In conclusion, CARLo‐5 was identified as a pro‐oncogenic lncRNA that may play an important role in EC progression and represent a prognostic marker for EC. The expression of CARLo‐5 was significantly correlated with the rs6983267 genotype associated with increased susceptibility to EC. Environ. Mol. Mutagen., 2016. © 2016 Wiley Periodicals, Inc. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - June 30, 2016 Category: Molecular Biology Authors: Xiwa Zhao, Xurui Wei, Lianmei Zhao, Li Shi, Jianxin Cheng, Shan Kang, Hui Zhang, Jun Zhang, Li Li, Haibo Zhang, Wei Zhao Tags: Research Article Source Type: research

Combining different assays and chemical analysis to characterize the genotoxicity of waters impacted by textile discharges
This study shows the value of combining assays measuring complementary endpoints to better characterize the mutagenicity of environmental samples, with the advantage that this approach provides an indication of what classes of compounds are responsible for the effect. Environ. Mol. Mutagen., 2016. © 2016 Wiley Periodicals, Inc. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - June 30, 2016 Category: Molecular Biology Authors: Francine I. Vacchi, Josiane A. S. Vendemiatti, Vanessa Brosselin, Bianca Ferreira da Silva, Maria Valnice B. Zanoni, Michel DeMeo, Sylvie Bony, Alain Devaux, Gisela A. Umbuzeiro Tags: Research Article Source Type: research

Epigenome ‐wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A
Developmental exposure to the endocrine‐active compound bisphenol A (BPA) has been linked to epigenotoxic and potential carcinogenic effects in rodent liver, prostate, and mammary glands. A dose‐dependent increase in hepatic tumors in 10‐month mice perinatally exposed to one of three doses of BPA (50 ng, 50 µg, or 50 mg BPA/kg chow) was previously reported. These tumors represent early‐onset disease and lack classical sexual dimorphism in incidence. Here, adult epigenome‐wide liver DNA methylation profiles to identify gene promoters associated with perinatal BPA exposure and disease in 10‐month mice with and w...
Source: Environmental and Molecular Mutagenesis - June 22, 2016 Category: Molecular Biology Authors: Caren Weinhouse, Maureen A. Sartor, Christopher Faulk, Olivia S. Anderson, Karilyn E. Sant, Craig Harris, Dana C. Dolinoy Tags: Research Article Source Type: research

Issue Information
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - June 15, 2016 Category: Molecular Biology Tags: Issue Information Source Type: research

Cover Image
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - June 15, 2016 Category: Molecular Biology Tags: Cover Image Source Type: research

Gene ‐environment interaction between the MMP9 C–1562T promoter variant and cigarette smoke in the pathogenesis of chronic obstructive pulmonary disease
The aetiology of chronic obstructive pulmonary disease (COPD) is complex. While cigarette smoking is a well‐established cause of COPD, a myriad of assessed genetic factors has given conflicting data. Since gene‐environment interactions are thought to be implicated in aetiopathogenesis of COPD, we aimed to examine the matrix metalloproteinase (MMP) 9 C–1562T (rs3918242) functional variant and cigarette smoke in the pathogenesis of this disease. The distribution of the MMP9 C–1562T variant was analyzed in COPD patients and controls with normal pulmonary function from Serbia. Interaction between the C–1562T genetic ...
Source: Environmental and Molecular Mutagenesis - June 6, 2016 Category: Molecular Biology Authors: Marija Stankovic, Snezana Kojic, Valentina Djordjevic, Andrija Tomovic, Ljudmila Nagorni ‐Obradovic, Natasa Petrovic‐Stanojevic, Marija Mitic‐Milikic, Dragica Radojkovic Tags: Research Article Source Type: research

Better living with hyper ‐mutation
The simplest forms of mutations, base substitutions, typically have negative consequences, aside from their existential role in evolution and fitness. Hypermutations, mutations on steroids, occurring at frequencies of 10−2−10−4 per base pair, straddle a domain between fitness and death, depending on the presence or absence of regulatory constraints. Two facets of hypermutation, one in Escherichia coli involving DNA polymerase V (pol V), the other in humans, involving activation‐induced deoxycytidine deaminase (AID) are portrayed. Pol V is induced as part of the DNA‐damage‐induced SOS regulon, and is responsible...
Source: Environmental and Molecular Mutagenesis - June 6, 2016 Category: Molecular Biology Authors: Myron F. Goodman Tags: Review Source Type: research

Gene‐environment interaction between the MMP9 C–1562T promoter variant and cigarette smoke in the pathogenesis of chronic obstructive pulmonary disease
The aetiology of chronic obstructive pulmonary disease (COPD) is complex. While cigarette smoking is a well‐established cause of COPD, a myriad of assessed genetic factors has given conflicting data. Since gene‐environment interactions are thought to be implicated in aetiopathogenesis of COPD, we aimed to examine the matrix metalloproteinase (MMP) 9 C–1562T (rs3918242) functional variant and cigarette smoke in the pathogenesis of this disease. The distribution of the MMP9 C–1562T variant was analyzed in COPD patients and controls with normal pulmonary function from Serbia. Interaction between the C–1562T genetic ...
Source: Environmental and Molecular Mutagenesis - June 6, 2016 Category: Molecular Biology Authors: Marija Stankovic, Snezana Kojic, Valentina Djordjevic, Andrija Tomovic, Ljudmila Nagorni‐Obradovic, Natasa Petrovic‐Stanojevic, Marija Mitic‐Milikic, Dragica Radojkovic Tags: Research Article Source Type: research

γH2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9
Previous work with a diverse set of reference chemicals suggests that an in vitro multiplexed flow cytometry‐based assay (MultiFlow™ DNA Damage Kit—p53, γH2AX, Phospho‐Histone H3) can distinguish direct‐acting clastogens and aneugens from nongenotoxicants (Bryce SM et al. []: Environ Mol Mutagen 57:171‐189). This work extends this line of investigation to include compounds that require metabolic activation to form reactive electrophiles. For these experiments, TK6 cells were exposed to 11 promutagens and 37 presumed nongenotoxicants in 96 well plates. Unless precipitation or foreknowledge about cytotoxicity su...
Source: Environmental and Molecular Mutagenesis - May 31, 2016 Category: Molecular Biology Authors: Derek T. Bernacki, Steven M. Bryce, Jeffrey C. Bemis, David Kirkland, Stephen D. Dertinger Tags: Research Article Source Type: research