Environmental and Molecular Mutagenesis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Application of the CometChip platform to assess DNA damage in field ‐collected blood samples from turtles
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - March 14, 2018 Category: Molecular Biology Source Type: research

Single nucleotide mtDNA polymorphisms may contribute to cancerogenesis in mitochondrial disorders
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - March 14, 2018 Category: Molecular Biology Source Type: research

Reply
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - March 14, 2018 Category: Molecular Biology Source Type: research

---
Environmental and Molecular Mutagenesis, Ahead of Print. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - March 14, 2018 Category: Molecular Biology Source Type: research

Application of the CometChip platform to assess DNA damage in field ‐collected blood samples from turtles
DNA damage has been linked to genomic instability and the progressive breakdown of cellular and organismal homeostasis, leading to the onset of disease and reduced longevity. Insults to DNA from endogenous sources include base deamination, base hydrolysis, base alkylation, and metabolism‐induced oxidative damage that can lead to single‐strand and double‐strand DNA breaks. Alternatively, exposure to environmental pollutants, radiation or ultra‐violet light, can also contribute to exogenously derived DNA damage. We previously validated a novel, high through‐put approach to measure levels of DNA damage in cultured m...
Source: Environmental and Molecular Mutagenesis - March 14, 2018 Category: Molecular Biology Authors: Peter Sykora, Ylenia Chiari, Andrew Heaton, Nickolas Moreno, Scott Glaberman, Robert W. Sobol Tags: Research Article Source Type: research

Reply
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - March 14, 2018 Category: Molecular Biology Authors: Neal Sondheimer, Brett Kaufman, Martin Picard Tags: Letter to the Editor Source Type: research

Single nucleotide mtDNA polymorphisms may contribute to cancerogenesis in mitochondrial disorders
(Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - March 1, 2018 Category: Molecular Biology Authors: Josef Finsterer, Sinda Zarrouk ‐Mahjoub Tags: Letter to the Editor Source Type: research

Conventional and novel “omics”‐based approaches to the study of carbon nanotubes pulmonary toxicity
The widespread application of carbon nanotubes (CNT) on industrial, biomedical, and consumer products can represent an emerging respiratory occupational hazard. Particularly, their similarity with the fiber‐like shape of asbestos have raised a strong concern about their carcinogenic potential. Several in vitro and in vivo studies have been supporting this view by pointing to immunotoxic, cytotoxic and genotoxic effects of some CNT that may conduct to pulmonary inflammation, fibrosis, and bronchioloalveolar hyperplasia in rodents. Recently, high throughput molecular methodologies have been applied to obtain more insightfu...
Source: Environmental and Molecular Mutagenesis - February 26, 2018 Category: Molecular Biology Authors: C élia Ventura, António Sousa‐Uva, João Lavinha, Maria João Silva Tags: Review Source Type: research

2 ‐Hydroxypyridine‐N‐oxide (HOPO): Equivocal in the ames assay
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - February 26, 2018 Category: Molecular Biology Source Type: research

Conventional and novel “omics”‐based approaches to the study of carbon nanotubes pulmonary toxicity
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - February 26, 2018 Category: Molecular Biology Source Type: research

---
Environmental and Molecular Mutagenesis, Ahead of Print. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - February 26, 2018 Category: Molecular Biology Source Type: research

2 ‐Hydroxypyridine‐N‐oxide (HOPO): Equivocal in the ames assay
2‐Hydroxypyridine‐N‐oxide (HOPO) is a useful coupling reagent for synthesis of active pharmaceutical ingredients. It has been reported to be weakly mutagenic in the Ames assay (Ding W et al. []: J Chromatogr A 1386:47–52). According to the ICH M7 guidance (2014) regarding control of mutagenic impurities to limit potential carcinogenic risk, mutagens require control in drug substances such that exposure not exceeds the threshold of toxicological concern. Given the weak response observed in the Ames assay and the lack of any obvious structural features that could confer DNA reactivity we were interested to determine ...
Source: Environmental and Molecular Mutagenesis - February 26, 2018 Category: Molecular Biology Authors: Krista L. Dobo, Jennifer R. Cheung, William C. Gunther, Michelle O. Kenyon Tags: Research Article Source Type: research